Schizophrenia as a progressive disorder: Relations to EEG, CT. neuropathological and other evidence

Miller, Robert J.

doi:10.1016/0301-0082(89)90034-8

Cited by 47 publications

(28 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In terms of possible underlying neuropathological processes, the hypothesis would predict that later-onset patients, with greater deterioration, would demonstrate progressive ~entricular enlargement early in the course of the illness; this may relate to excitotoxic damage resulting from repeated psychotic episodes 1994;35:517-524 (Miller 1989;Woods and Yurgelun-Todd 1991). In early onset patients, with normal ventricles and poorer premorbid functioning, processes unrelated to generalized cell loss, for example, aberrant hippocampal cell migration (Scheibel and Kovelman 1981;Akbarian et al 1993) may be involved.…”

Section: Discussionmentioning

confidence: 99%

“…A second strategy for resolving this question would be to determine whether ventricular enlargement is present at the onset of schizophrenia and whether it progressed during the course of the illness. Findings in the literature are controversial, with evidence for (Miller 1989;Kemali et al 1989;Woods et al 1990) and against progression Illowsky et al 1988;Vita et al 1988;Sponheim et al 1991). Ventricle size appears to be unrelated to duration and treatment of schizophrenic illness (Farmer et al 1987;Lawson et al 1988).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia

DeQuardo

Tandon

Goldman

et al. 1994

Biological Psychiatry

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia

DeQuardo

Tandon

Goldman

et al. 1994

Biological Psychiatry

View full text Add to dashboard Cite

“…It has been proposed that prolonged high cortical activity can cause cellular death, by an excitotoxicity mechanism, in areas that receive convergence of these impulse such as hippocampus and amygdala, structures that are involved in cognitive processes [2,11]. Consequently, a repetition of episodic high activity in the PFC could affect learning and memory processes.…”

Section: Introductionmentioning

confidence: 99%

“…More specifically, the medial PFC consists of the joining of the anterior cingulate cortex (Cg1, Cg2 and Cg3) and Fr2 area from the frontal cortex (Fr2) [4]. Lesions in this cortical area in rats produce many behavioral alterations, almost all of which are manifested as disorders of cognition [2,6,7], for example, deficits in learning of delayed tasks and impairment in the retention of strategies for the performance of an 8-arm radial maze and a Morris aquatic maze [8][9][10][11]. The radial maze is considered one of the most sensitive methods to investigate neuronal systems and neurotransmitters involved in spatial learning and memory processes in rodents [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Behavioral and Cognitive Effects Produced by Electrical Stimulation in the Medial Prefrontal Cortex:An Experimental Model for High Cortical Activation

Penna¹,

Lee²,

Silva³

et al. 1998

Neuropsychobiology

View full text Add to dashboard Cite

An electrical stimulation (ES) session with ten 30-second trains of sine-wave stimuli (30–100 µA, 60 Hz) separated by 30-second intervals was conducted daily in rats with electrodes implanted in the left or right or in both sides of the medial prefrontal cortex (PFC; B = + 2 mmA, + or –0.6 unilateral or 1 mmL bilateral, + 2.7 mmV). The unilateral and bilateral ES in the medial PFC produced abnormal behaviors such as circling spying, body stretching and immobility, and did not affect either the acquisition or the performance of delayed tasks in the 8-arm radial maze conducted 8–10 h after the ES session. However, animals that showed convulsions when the bilateral ES was applied in the medial PFC showed significant deficits in spatial learning and in the performance of short-term (5-second delay) and long-term (1-hour delay) working memory. The behavioral and cognitive effects induced by repeated episodic ES in the medial PFC provide an experimental model to study the effects of increased cortical activation on cognitive processes.

show abstract

“…Após um início insidioso, haveria um descenso progressivo no funcionamento intelectual e habilidades sociais (Miller, 1989;Davidson et al, 1995).…”

Section: Curso Do Déficit Cognitivo Em Esquizofreniaunclassified

Reabilitação vocacional e suas implicações no funcionamento cognitivo de pacientes esquizofrênicos

Bio¹

View full text Add to dashboard Cite

confiança em meu trabalho e por me incentivar a trilhar os caminhos da pesquisa científica.Agradeço a equipe do Programa ReAção, em especial a assistente social Lais Aun Machado, que acolheu os pacientes e os ajudou a superar os medos e dificuldades, com muito carinho e dedicação tornou este projeto possível.Aos meus pais, Daniel e Cecília, por seu amor incondicional, por todo o esforço que fizeram para que eu pudesse estudar e por todo o incentivo para que eu alcançasse os objetivos mais distantes.A minha irmã Cibelle, por ser mais que uma irmã, uma companheira na jornada da vida, um modelo e uma amiga.Ao meu cunhado Thiago por seu interesse e apoio.As minhas avós Luiza e Zenaide, por acreditarem em mim e por terem sempre uma palavra de conforto nos momentos mais estressantes. Agradeço também por todas as orações.Ao meu namorado Daniel, que esteve ao meu lado todo o tempo, tendo sido sempre compreensivo com minhas ausências e impaciências, pelo seu interesse e por toda a ajuda.A todos os meus amigos por sua compreensão e apoio nos momentos de maior estresse e sobrecarga.A FAPESP pelo apoio financeiro desta dissertação. NORMATIZAÇÃO ADOTADAEsta dissertação está de acordo com as seguintes normas em vigor no momento desta

show abstract

Schizophrenia as a progressive disorder: Relations to EEG, CT. neuropathological and other evidence

Cited by 47 publications

References 168 publications

Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia

Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia

Behavioral and Cognitive Effects Produced by Electrical Stimulation in the Medial Prefrontal Cortex:An Experimental Model for High Cortical Activation

Reabilitação vocacional e suas implicações no funcionamento cognitivo de pacientes esquizofrênicos

Contact Info

Product

Resources

About