Schizophrenia in patients with atopic disorders with particular emphasis on asthma: A Danish population-based study

Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study

“…A longitudinal association between asthma and subsequent hospitalization for schizophrenia, and adult diagnoses of depression has been reported (Timonen et al 2003;Pedersen et al 2012;Sanna et al 2014), and three longitudinal studies have reported increased rates of bipolar disorder in individuals with asthma (Liang & Chikritzhs, 2013;Chen et al 2014;Lin et al 2014). IL-6, C-reactive protein (CRP) and other inflammatory markers are associated with asthma and eczema (Takemura et al 2006;Arif et al 2007;Rincon & Irvin, 2012).…”

Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia

“…Results of Pedersen et al (2012) indicated comorbidity of schizophrenia and atopic diseases, both with predominance of type-2 immune response (74). In humans, as well as in mouse models of asthma, allergen challenge increases BDNF levels in bronchoalveolar lavage fluid (75).…”

A predisposition for allergies predicts subsequent hypertension, dyslipidemia, and diabetes mellitus among patients with schizophrenia or bipolar disorder: A nationwide longitudinal study

“…Previous studies have reported the relationship of atopy or a predisposition for allergies with schizophrenia and bipolar disorder (Goodwin et al, 2003;Chen et al, 2009;Jerrell et al, 2010;Pedersen et al, 2012). Chen et al surveyed the prevalence of atopic diseases among 44,187 patients with schizophrenia and found that more than 20% of them had experienced concurrent atopic diseases (Y. H. Chen et al, 2009).…”

“…Chen et al surveyed the prevalence of atopic diseases among 44,187 patients with schizophrenia and found that more than 20% of them had experienced concurrent atopic diseases (Y. H. Chen et al, 2009). A Danish population-based study showed that atopic diseases, especially asthma, increased the rate ratio of schizophrenia by 1.45 (95% confidence interval [CI]: 1.31-1.90) (Pedersen et al, 2012). Jerrell et al demonstrated a significantly higher prevalence of asthma among 1841 patients with bipolar disorder than among 4500 controls (25.7% vs. 22.7%, p b 0.01) (Jerrell et al, 2010).…”