1985
DOI: 10.1192/bjp.146.3.239
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Schizophrenia with Good and Poor Outcome II: Cerebral Ventricular Size and its Clinical Significance

Abstract: Computer tomography brain scans were carried out on 40 patients with schizophrenia or schizo-affective disorder of 2-20 years duration. Ventricular-brain ratio (VBR) was significantly greater than that of the control group. In six patients the VBR exceeded the control mean + 2 s.d. Among the 13 whose VBR was more than 1 s.d. above the control mean, none had schizo-affective disorder, all but one had chronic illness, and patients with negative symptoms and those with premorbid schizoid traits were over-represen… Show more

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Cited by 151 publications
(40 citation statements)
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“…Concerning gender and brain abnormalities, many previous studies have shown that patients with markedly expressed negative symptoms were more likely to be of male gender (Angermeyer et al 1990; Carpenter et al 1988; Goldstein et al 1988; Szymanski et al 1995) and to have brain abnormalities (Davis et al 1998;Johnstone et al 1994;Pearlson et al 1984; Williams et al 1985). The reason for the better outcome in female patients compared to male patients with schizophrenia was mainly seen in a better premorbid functioning in females than in males (Salokangas et al 1990).…”
Section: Introductionmentioning
confidence: 99%
“…Concerning gender and brain abnormalities, many previous studies have shown that patients with markedly expressed negative symptoms were more likely to be of male gender (Angermeyer et al 1990; Carpenter et al 1988; Goldstein et al 1988; Szymanski et al 1995) and to have brain abnormalities (Davis et al 1998;Johnstone et al 1994;Pearlson et al 1984; Williams et al 1985). The reason for the better outcome in female patients compared to male patients with schizophrenia was mainly seen in a better premorbid functioning in females than in males (Salokangas et al 1990).…”
Section: Introductionmentioning
confidence: 99%
“…) replicated findings in schizophrenia research (8). Although it is nonspecific in nature, the ventricular dilation observed in subjects with schizophrenia is significant for its association with cognitive impairment (6), poor treatment response (9), and a negative prognosis (10). Overall, the finding of diffuse volume loss in brain imaging studies of schizophrenia has been a key element in the argument that schizophrenia is a degenerative disorder in which neuronal death may play a central role (for a review, see reference 8).…”
mentioning
confidence: 99%
“…The correlation between lateral ventricle volume and negative symptoms has long been described in patients affected by chronic schizophrenia (e.g. Kemali et al 1987; Klausner et al 1992; Nakamura et al 2007; Nesvåg et al 2012; Pearlson et al 1989; Williams et al 1985), while in schizophrenia, improvement of disorganization symptoms has been shown to be inversely related to hippocampal volume (Molina et al 2003). These trend level correlations will need to be replicated in larger CHR populations as they recapitulate findings in schizophrenia.…”
Section: Discussionmentioning
confidence: 99%