Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model

Garza-Castro, Oscar de la; Martı́nez-Rodrı́guez, Herminia Guadalupe; Sánchez-González, Sandra Gabriela; Vidal-Torres, Oscar; Arreola-Romero, Azalea; Garza-Pineda, Oscar De La; Ancer-Arellano, Adriana; Guzmán-López, Santos; Elizondo‐Omaña, Rodrigo Enrique

doi:10.24875/ric.18002466

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…The authors reported that the transplantation resulted in improvements in locomotor function which were highly significant when compared to the control group. It is of interest that the levels of locomotor recovery in the SC-transplanted group far exceeded the levels of recovery reported for animals receiving a mesenchymal stem cell transplant ( De La Garza-Castro et al, 2018 ). These findings highlight not just the potential of SC transplantation but further emphasize the potential of stem cell directed strategies as well as the importance of stem cell origin and nature for determining regenerative outcomes.…”

Section: The Quest For Axonal Regenerationmentioning

confidence: 95%

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

et al. 2022

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Neuronal regeneration in the central nervous system (CNS) is an important field of research with relevance to all types of neuronal injuries, including neurodegenerative diseases. The glial scar is a result of the astrocyte response to CNS injury. It is made up of many components creating a complex environment in which astrocytes play various key roles. The glial scar is heterogeneous, diverse and its composition depends upon the injury type and location. The heterogeneity of the glial scar observed in different situations of CNS damage and the consequent implications for axon regeneration have not been reviewed in depth. The gap in this knowledge will be addressed in this review which will also focus on our current understanding of central axonal regeneration and the molecular mechanisms involved. The multifactorial context of CNS regeneration is discussed, and we review newly identified roles for components previously thought to solely play an inhibitory role in central regeneration: astrocytes and p75NTR and discuss their potential and relevance for deciding therapeutic interventions. The article ends with a comprehensive review of promising new therapeutic targets identified for axonal regeneration in CNS and a discussion of novel ways of looking at therapeutic interventions for several brain diseases and injuries.

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Section: The Quest For Axonal Regenerationmentioning

confidence: 95%

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

et al. 2022

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“…In the PNS, unlike the CNS, regeneration is efficient due to the presence of Schwann cells (Cs). Cs have been used to perform transplants in different animal models since they are capable of: engulfing cellular debris, producing trophic factors necessary for the survival of the neuron (especially brain-derived neurotrophic factor (BDNF) and neurotrophin 4/5 (NT4/5)), secreting cell matrices of inhibitory molecules that help axonal regrowth, and producing myelin layers to envelop the naked axons and increase the impulse speed of nerve cells to improve their functioning [31]. In rodent models, Cs implants have been shown to foster remyelination, thus improving motor functions in contusion and complete section injuries [32,33].…”

Section: Schwann Cellsmentioning

confidence: 99%

Strategies to Repair Spinal Cord Injuries: Single Vs. Combined Treatments

Buzoianu-Anguiano¹,

Estrada²

2021

Paraplegia

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Several experimental strategies have been developed in past years for the repair of damages evoked in axons, myelin, and motor functions by spinal cord injuries. This chapter briefly reviews some of such strategies. On the one hand, it examines individual procedures, such as: tissue or cell transplants (i.e. evolving cells of the olfactory glia or mesenchymal cells), implants of biomaterials (fibrine and chitosan), application of enzymes (chondroitinase and ChABC), growth factors (brain-derived neurotrophic factor, BDNF; neurotrophin-3, NT-3; or glial-derived neurotrophic factor, GDNF), and drugs (myocyclines or riluzole) among others, that induce different recovery degrees in axonal regeneration, myelination, and motor performance in experimental animals. On the other hand, it also examines the recent strategy of combining some of the previous experimental procedures to potentialize the positive effects evoked by each one in experimentally spinal cord lesioned animals and explores the possible use of this strategy in future preclinical research for the treatment of spinal cord lesions.

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“…Spinal cord injury (SCI) can cause the loss of neurological function depending on the severity and location of the injury. [1] SCI constitutes a medical emergency, and the time between injury and treatment is critical in reducing comorbidities and sequelae and determines the ultimate prognosis. [1] As a result, traumas that cause SCI lead to partial or complete disability depending on their extent and level.…”

Section: Introductionmentioning

confidence: 99%

“…[1] SCI constitutes a medical emergency, and the time between injury and treatment is critical in reducing comorbidities and sequelae and determines the ultimate prognosis. [1] As a result, traumas that cause SCI lead to partial or complete disability depending on their extent and level. Despite long rehabilitation periods, this situation has a permanent destructive effect both emotionally and financially on patients and their families.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis

Keskin¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Annona muricata (AM) (graviola) is a plant that grows in tropical regions and is thought to be good for many diseases by local people. Unfortunately, there is no acceptable medical treatment for spinal cord injury (SCI) yet. In our study, we investigated the neuropeotective effects of AM leaf extract on SCI in an experimental rat model. METHODS:A total of 40 Wistar albino rats were randomly divided into five equal groups (n=8). Group 1 was the control group in which only laminectomy was performed. Trauma was induced in four groups after laminectomy. Group 2 (untreated trauma group) was given no medication. In Group 3, a single intraperitoneal dose of methylprednisolone (30 mg/kg) was administered after trauma. The rats in Groups 4 received a low dose (100 mg/kg) of AM leaf extracts by oral gavage one week before trauma while the rats in Group 5 received a high-dose (300 mg/kg) of these extracts by oral gavage one week before trauma. All rats, including the control group, were sacrificed 24 h after the trauma was created.RESULTS: Tissue samples taken to evaluate the neuroprotective effect were examined biochemically and histopathologically. Inflammatory findings in the trauma group were significantly better in both groups treated with AM. There was no difference between the groups in terms of clinical motor examination and inclined plane test results. CONCLUSION:Our histopathological and biochemical results showed that AM is an agent with neuroprotective effects in traumatic SCI.

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Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model

Abstract: Schwann precursor cells had a greater effect on locomotive function than mesenchymal stem cells.

Cited by 5 publications

References 13 publications

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

Strategies to Repair Spinal Cord Injuries: Single Vs. Combined Treatments

Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis

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