Sciatic nerve regeneration with collagen type I hydrogel containing chitosan nanoparticle loaded by insulin

Ai, Armin; Behforouz, Aria; Ehterami, Arian; Sadeghvaziri, Nooshin; Jalali, Samar; Farzamfar, Saeed; Yousefbeigi, Aylar; Ai, Arman; Goodarzi, Arash; Salehi, Majid; Ai, Jafar

doi:10.1080/00914037.2018.1534114

Cited by 35 publications

(14 citation statements)

References 37 publications

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“…Other materials have been proposed for tissue regeneration applications, such as chitosan NPs. Ai et al (2019) proposed collagen hydrogel containing insulin-loaded chitosan NPs to promote the regeneration of the sciatic nerve caused by traumatic injury or some diseases [ 51 ]. Although clinically used to regulate blood glucose, recent evidence has shown that insulin possesses neurotrophic activities.…”

Section: Routes Of Drugs Administrationmentioning

confidence: 99%

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

et al. 2022

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Clinically available medications face several hurdles that limit their therapeutic activity, including restricted access to the target tissues due to biological barriers, low bioavailability, and poor pharmacokinetic properties. Drug delivery systems (DDS), such as nanoparticles (NPs) and hydrogels, have been widely employed to address these issues. Furthermore, the DDS improves drugs’ therapeutic efficacy while reducing undesired side effects caused by the unspecific distribution over the different tissues. The integration of NPs into hydrogels has emerged to improve their performance when compared with each DDS individually. The combination of both DDS enhances the ability to deliver drugs in a localized and targeted manner, paired with a controlled and sustained drug release, resulting in increased drug therapeutic effectiveness. With the incorporation of the NPs into hydrogels, it is possible to apply the DDS locally and then provide a sustained release of the NPs in the site of action, allowing the drug uptake in the required location. Additionally, most of the materials used to produce the hydrogels and NPs present low toxicity. This article provides a systematic review of the polymeric NPs-loaded hydrogels developed for various biomedical applications, focusing on studies that present in vivo data.

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Section: Routes Of Drugs Administrationmentioning

confidence: 99%

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

et al. 2022

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“…Negative control (D nc was mixture of 0.2 ml of diluted blood and 10 ml of normal saline while a combination of 0.2 ml diluted blood and 10 ml of deionized water was positive control (D pc ). Equation 3was used to calculate hemolysis [34].…”

Section: Blood Compatibilitymentioning

confidence: 99%

Bone Regeneration in Rat Using a PCL/gelatin/Nanoclay Nanocomposite Scaffold Containing Silybin

Tayeed

Tehranchi

Ehterami

et al. 2021

Preprint

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Bone cells need solid structures like the extracellular matrix (ECM) for healing injured areas. Finding appropriate materials and fabrication processes for the scaffold is a challenge in tissue engineering. In this study, 3-D porous scaffold was made of Polycaprolactone/Gelatin/Nanoclay (PCL/GNF/NC) and different dosages of silybin (Sil) were loaded by a combination of electrospinning and thermal-induced phase separation (TIPS) techniques. Different experiments like assessing surface morphology, porosity, compressive strength, water contact angle, degradation rate, releasing profile, hemolysis, and cell proliferation were done to assess attributes of fabricated scaffolds. For in vivo evaluation, the calvaria defect model in rats was used and the result was evaluated by histological analysis. Based on the results, the porosity of scaffolds was in the range of 70-90%, and samples containing silybin had lower compress strength and contact angle and higher degradation rate in comparison with samples without silybin. The results showed that PCL/GNF/NC/Sil1% had better cell proliferation bone healing than other studied groups. The results of this study can be considered for further researches to assess the effect of silybin in bone defect treatment.

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“…In this article, chitosan and alginate combined were chosen as a protein carrier. These two polysaccharides are both naturally occurring biopolymers that could be applied as pH-sensitive hydrogels applicable for the delivery of proteins [20][21][22]. Both of these materials were selected due to high biocompatibility, biodegradability, and nontoxicity [22,23].…”

Section: -Backgroundmentioning

confidence: 99%

In Vitro/In Vivo Evaluation of Sustained Release of Glucagon-Like Peptide-1 (GLP-1) from Nanocomposite Hydrogel to Induce Angiogenesis

Kiaei

Aghdam

2020

Preprint

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Background: Glucagon-like peptide-1 (GLP-1) is a proglucagon hormone with cardioprotective effects and angiogenic ability. Results: Chitosan nanoparticles (65nm) possess the ability to encapsulate 65±4.1% of the GLP-1 used for the formulation of nanoparticles. Freeze-dried gels containing these particles released 40% of the total loaded GLP-1 during 192 hours. Field emission scanning electron microscopy was done to observe the morphology of particles both alone or when embedded into a gel. Results of in vivo studies and histological images showed that following the gradual release of GLP-1, new vessels formed into and around gels implanted into the back of rats. Through Drabkin assay, it was observed that the concentration of hemoglobin in the samples containing GLP-1 loading were similar to samples with VEGF loading, while a significant difference exists between hemoglobin concentration in sponges with or without GLP-1 release (P<0.05). Conclusion: Sustained release of GLP-1 induced new vessel formation in a subcutaneous in vivo model of angiogenesis. This system has the potential to induce angiogenesis in myocardial infarction situations.

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Sciatic nerve regeneration with collagen type I hydrogel containing chitosan nanoparticle loaded by insulin

Cited by 35 publications

References 37 publications

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

Bone Regeneration in Rat Using a PCL/gelatin/Nanoclay Nanocomposite Scaffold Containing Silybin

In Vitro/In Vivo Evaluation of Sustained Release of Glucagon-Like Peptide-1 (GLP-1) from Nanocomposite Hydrogel to Induce Angiogenesis

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Sciatic nerve regeneration with collagen type I hydrogel containing chitosan nanoparticle loaded by insulin

Cited by 35 publications

References 37 publications

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

Bone Regeneration in Rat Using a PCL/gelatin/Nanoclay Nanocomposite Scaffold Containing Silybin

In&nbsp;Vitro/In&nbsp;Vivo Evaluation of Sustained Release of Glucagon-Like&nbsp;Peptide-1&nbsp;(GLP-1)&nbsp;from Nanocomposite Hydrogel to Induce Angiogenesis

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In Vitro/In Vivo Evaluation of Sustained Release of Glucagon-Like Peptide-1 (GLP-1) from Nanocomposite Hydrogel to Induce Angiogenesis