Scientific correspondence

Lechapt‐Zalcman, Emmanuèle; Chapon, F.; Guillamo, J-S.; Khouri, S.; Menegalli-Boggelli, D.; Loussouarn, Delphine; Fèvre‐Montange, Michelle; Jouvet, Anne

doi:10.1111/j.1365-2990.2010.01133.x

Cited by 19 publications

(7 citation statements)

References 21 publications

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“…The patients received 50-and 55 -Gy radiation, as well as chemotherapy. Although local recurrence occurred twice, the patients were well and alive for 218 and 240 months after presentation, respectively (21)(22)(23)(24). There are other reports of PTPR in patients who did not undergo complete tumor resection and remained well for a long period (84 and 108 months, respectively) (9, 25).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 90%

“…After the third recurrence, the patient received nine cycles of etoposide and carboplatin. He was well for six years, when recurrence occurred (22). At the time of report, 42 patients had no recurrence.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 91%

“…A new lesion appeared in the cerebellum 14 years after the primary diagnosis, and he received temozolomide. He underwent surgery 16 and 17 years after the presentation of tumor, which was successfully removed (22).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

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Papillary Tumor of the Pineal Region: Clinical Presentations, Prognostic Factors, Treatments, and Outcomes

Nasrollahi

Kadkhodaei

Hamedi

et al. 2016

Rep Radiother Oncol

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The pineal region is a rare site for primary tumors of the central nervous system. Papillary tumor of the pineal region (PTPR) is a relatively new phenomenon in this region. Considering the rarity of this tumor, the clinical course, treatment, and outcomes are not well studied. In the present study, we searched PubMed for relevant articles. A total of 72 articles were retrieved from PubMed. The exclusion criteria were autopsy and archive series, animal studies, and reports without clinical data. We had no access to the full -text of some articles; accordingly, 19 articles were excluded from the analysis. Data from 53 reports, including 50 case reports and three case series (a total of 73 patients), were collected and analyzed. The patients' mean age was 33.5 (± 15.4) years. Forty -two cases were male and 31 were female. The most common symptom was headache in patients (80%). Other common symptoms included visual complaints (40%), nausea (31%), memory loss (7%), Parinaud's syndrome (4%), and impaired gait (2%). Among 73 patients, 32 had undergone complete tumor resection. Twenty -nine patients had received conventional external beam radiotherapy, stereotactic radiosurgery (n, 10), brachytherapy (n, 5), and proton therapy (n, 1). Eight patients received no adjuvant therapy, and data presented in other reports were incomplete. Among the patients (n, 73), 11 received chemotherapy. Fifty patients had no evidence of recurrence at the time of report, while three patients had died. Local recurrence was the most common pattern of relapse (28%); nonetheless, parenchymal and meningeal involvement was also observed. The median disease -free survival (DFS) was 24 months, while fiveand ten -year DFS rates were 50.1% and 25.0%, respectively. The median overall survival was 24 months. Generally, PTPR has an indolent course with a tendency towards local recurrence; nonetheless, an aggressive clinical course, associated with parenchymal and meningeal metastases, is well established.

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Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 90%

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 91%

See 1 more Smart Citation

Papillary Tumor of the Pineal Region: Clinical Presentations, Prognostic Factors, Treatments, and Outcomes

Nasrollahi

Kadkhodaei

Hamedi

et al. 2016

Rep Radiother Oncol

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“…However, most pathologic descriptions of PTPR are from primary or early resections, rather than from recurrences. In 1 case, a resected recurrent PTPR had an increased proliferation rate, increased anaplasia, and necrosis without microvascular proliferation [6]. …”

Section: Discussionmentioning

confidence: 99%

“…Neither radiation nor chemotherapy has been shown to improve survival [20]. Other treatments for PTPR have included adjuvant and neoadjuvant temozolomide after complete resection, adjuvant temozolomide/etoposide after complete resection, adjuvant carboplatin/etoposide following resection, and ACNU given after radiation but before surgery [6, 7, 21, 22]. When the treatment was either adjuvant after surgery and/or radiation or concomitant with radiation, the independent effect of the systemic chemotherapy could not be assessed.…”

Section: Discussionmentioning

confidence: 99%

Bevacizumab is Effective for Recurrent Papillary Tumor of the Pineal Region: First Report

Cohen

Salzman

Palmer³

et al. 2013

Case Rep Oncol

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Papillary tumor of the pineal region (PTPR) is a rare brain tumor that probably arises from ependymal cells. There are no known systemic treatments for PTPR once it is refractory to surgery and radiation. We present the first case of a durable radiographic and clinical response of a PTPR to bevacizumab, an antibody against vascular endothelial growth factor, despite multiple prior treatments. Bevacizumab may be an effective treatment for PTPR.

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Complete regression of papillary tumor of the pineal region after radiation therapy: case report and review of the literature

et al. 2011

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Papillary tumor of the pineal region (PTPR) is a rare neuroepithelial tumor that arises in the pineal region. The optimal treatment for PTPR remains controversial, as no definitive treatment strategy exists for this lesion. It is not clear whether aggressive surgical removal is superior to biopsy followed by radiotherapy. The majority of cases in the literature have undergone attempted gross total resection with a supracerebellar-infratentorial or a transcallosal-transventricular approach. In this report, we describe a case of PTPR in a 23 year-old male that presented as a third ventricular mass causing obstructive hydrocephalus. An endoscopic third ventriculostomy was performed followed by an endoscopic biopsy. Postoperative radiotherapy resulted in complete regression of the tumor with no evidence of tumor recurrence at 25 months. This case highlights a minimally invasive strategy for a rare neoplasm that resulted in a favorable response to radiation therapy, thereby avoiding the risks of aggressive surgical removal. We also review the radiographic and histopathologic features of PTPR and discuss various options of treatment reported in the literature.

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Scientific correspondence

Cited by 19 publications

References 21 publications

Papillary Tumor of the Pineal Region: Clinical Presentations, Prognostic Factors, Treatments, and Outcomes

Papillary Tumor of the Pineal Region: Clinical Presentations, Prognostic Factors, Treatments, and Outcomes

Bevacizumab is Effective for Recurrent Papillary Tumor of the Pineal Region: First Report

Complete regression of papillary tumor of the pineal region after radiation therapy: case report and review of the literature

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