Scientific Integrity and Misconduct—Yet Again

Kharasch, Evan D.

doi:10.1097/aln.0000000000003916

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…In some cases, the evidence has been overwhelming, as in the cases of anaesthesia researchers Yoshitaka Fujii, Joachim Boldt, and others. 1,4,14,36 In other cases, the overall patterns of data put any natural explanation out of reach, leaving reasonable doubt about investigator conduct. None of the included trials were published in journals suspected or presumed to be "predatory" in nature (see Supplementary Table 4, available at http://links.lww.com/PAIN/B628).…”

Section: Discussionmentioning

confidence: 99%

“…When comparing the baseline characteristics of participants in the trials of spinal pain with published norms, 27 we observed that baseline pain intensity levels were unremarkable. In some included trials, average baseline scores for HRQoL on the SF-36 subdomains of Role Function, Social Function and Vitality, [14][15][16][17][18][19] and Physical Function 15,16,19 were notably higher than those observed in the published norms (Supplementary Table 1, available at http://links.lww.com/PAIN/B628). However, we judged that these observations were not sufficiently remarkable to warrant a positive risk judgement on the CPC-TST for any trial.…”

Section: Feasibility Of Participant Characteristicsmentioning

confidence: 94%

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Investigating the veracity of a sample of divergent published trial data in spinal pain

O’Connell

Moore²,

Stewart

et al. 2022

Pain

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Section: Discussionmentioning

confidence: 99%

Section: Feasibility Of Participant Characteristicsmentioning

confidence: 94%

Investigating the veracity of a sample of divergent published trial data in spinal pain

O’Connell

Moore²,

Stewart

et al. 2022

Pain

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show abstract

“…Yoshitaka Fujii and Yuhji Saitoh were respectively ranked as the first (183 publications) and seventh position (53 publications) in the number of retracted articles globally ( 28 ). Further, Dr. Hironobu Ueshima, a Japanese anesthesiologist was found guilty of fabricating data and other misconduct in 142 publications in 2021, a majority of which have not been retracted yet ( 29 ). One possible reason of the notoriety of the Japanese anesthesiology field is that anesthesiologists enjoy fewer career choices compared to other medical specialties in Japan.…”

Section: Generalizability and Uniqueness Of This Casementioning

confidence: 99%

How Do Institutional Conflicts of Interest Between Pharmaceutical Companies and the Healthcare Sector Become Corrupt? A Case Study of Scholarship Donations Between Department of Clinical Anesthesiology, Mie University, and Ono Pharmaceutical in Japan

Ozaki

Murayama

Harada

et al. 2022

Front. Public Health

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Institutional conflicts of interest (ICOIs) with pharmaceutical companies can bias internal operation of healthcare organizations. Naturally, a scholarship donation—which is a donation scheme unique to Japan, provided to healthcare organizations and their subunits to encourage educational and academic activities related to the development of new drugs—fall into the ICOI category. While anecdotal evidence exists that scholarship donations have been used as bribes by pharmaceutical companies, there has been little case study research that would illuminate the workings of this “gray area” mechanism. From this perspective, we offer an in-depth analysis of a recent scandal involving the Department of Clinical Anesthesiology, Mie University and Ono Pharmaceutical, where a scholarship donation was used by a pharmaceutical company to increase the prescription of one of its key drugs at a hospital department. Available evidence also suggests that a professor based within the department originally requested a scholarship donation from the company, which became an initial trigger of the scandal. We argue that by scrutinizing scholarship donations we can gain insight into problems specific to ICOIs between the pharmaceutical companies and the healthcare sector in Japan. In addition, scholarship donations can be understood as a form of “gifts” which have been found to underpin certain forms of pharmaceutical companies' promotional activities in Japan but also in other countries. We conclude by highlighting potential institutional remedies, which may alleviate ICOIs and corrupt behavior affecting the healthcare sector.

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“…In 2020, more than 2300 articles were retracted, an alarming increase considering that there were 38 in 2000 1. The anesthesiology field is not immune to this phenomenon, which includes three major scandals where renowned researchers engaged in scientific misconduct in more than one hundred research articles each 2…”

Section: Introductionmentioning

confidence: 99%

Citing retracted literature: a word of caution

Cassai

Volpe

Geraldini

et al. 2023

Reg Anesth Pain Med

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IntroductionInappropriate citation of retracted literature is a common problem in the general medical literature. In 2020, more than 2300 articles were retracted, a dramatic increase from 38 in 2000. By exploring a contemporary series of retractions by one research group, we aimed to evaluate if citations of retracted articles is occurring in the area of regional anesthesiology.MethodsUsing the Scopus database, we examined the full text of all the articles citing research articles coauthored by an anesthesiologist who had multiple articles retracted in 2022. After excluding the research articles citing non-retracted articles authored by the above mentioned anesthesiologist, we included in our analysis all the articles containing a retracted citation and published after the retraction notice.ResultsThe search was performed on October 30, 2022, retrieving a total of 121 articles citing the researcher’s work. Among the retrieved articles, 53 correctly cited non-retracted research and 37 were published before the retraction notice. Among the 31 remaining articles, 42 retracted research papers were cited. Twenty-five of the retracted articles were cited in the Discussion section of the manuscripts, 15 in the Introduction section, 1 in the Methods section (description of a technique), and one was cited in a review. No manuscript used the flawed data to calculate the sample size.DiscussionIn this contemporary example from the regional anesthesia literature, we identified that citation of retracted work remains a common phenomenon.

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Scientific Integrity and Misconduct—Yet Again

Cited by 13 publications

References 22 publications

Investigating the veracity of a sample of divergent published trial data in spinal pain

Investigating the veracity of a sample of divergent published trial data in spinal pain

How Do Institutional Conflicts of Interest Between Pharmaceutical Companies and the Healthcare Sector Become Corrupt? A Case Study of Scholarship Donations Between Department of Clinical Anesthesiology, Mie University, and Ono Pharmaceutical in Japan

Citing retracted literature: a word of caution

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