Scientific Opinion on Dietary Reference Values for folate

Products, Efsa Panel on Dietetic

doi:10.2903/j.efsa.2014.3893

Cited by 106 publications

(99 citation statements)

References 228 publications

(411 reference statements)

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“…In 2014, EFSA provided an opinion on the dietary reference values for folate (EFSA NDA Panel, 2014). For infants aged 7-11 months an adequate intake (AI) for folate was set at 80 lg dietary folate equivalents (DFE)/day but no UL could be defined.…”

Section: Information On Existing Evaluations and Authorisationsmentioning

confidence: 99%

“…The EFSA opinion on dietary reference values for folate (EFSA NDA Panel, 2014) reports results on dietary intake of folate for one national survey for infants (0.5 to < 1 year) reporting median DFE intake of 70 lg/day, and two national surveys for young children (1 to < 4 years) reporting median DFE intakes ranging from 111 to 128 lg/day. The EFSA opinion on dietary reference values for folate (EFSA NDA Panel, 2014) reports results on dietary intake of folate for one national survey for infants (0.5 to < 1 year) reporting median DFE intake of 70 lg/day, and two national surveys for young children (1 to < 4 years) reporting median DFE intakes ranging from 111 to 128 lg/day.…”

Section: Combined Intake From the Nutrient Source And Other Sourcesmentioning

confidence: 99%

“…Folate belongs to the group of B-vitamins and is the generic name for a number of compounds having a similar activity to folic acid, which is essential for the synthesis of ribo-and deoxyribonucleic acids (RNA and DNA) and consequently for cell division and tissue growth, methylation reactions and amino acid metabolism (EFSA NDA Panel, 2014). Calcium L-methylfolate is intended to be used as an alternative to folic acid in infant formula and follow-on formula and in processed cereal-based food and baby food (see Section 3.7).…”

Section: Nutritional Informationmentioning

confidence: 99%

See 2 more Smart Citations

Calcium l‐methylfolate as a source of folate added for nutritional purposes to infant and follow‐on formula, baby food and processed cereal‐based food

Turck¹,

Castenmiller²,

Henauw³

et al. 2020

EFS2

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Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the extension of use of calcium L-methylfolate to be used as a source of folate added for nutritional purposes to infant and follow-on formula, baby food and processed cereal-based food pursuant to Regulation (EU) 609/2013. In 2004, EFSA assessed the use of calcium L-methylfolate as a source of folate in foods for particular nutritional uses, food supplements and foods intended for the general population. The new alternative synthetic step proposed to produce the nutrient source, using platinum as a catalyst, did not raise any safety concern and the production process was found to consistently yield a product in line with the proposed specifications. Based on the studies assessed in the previous evaluation, it was concluded that calcium L-methylfolate is non-genotoxic and that subchronic and embryotoxicity/teratogenicity studies in rats did not reveal any adverse effects up to the highest doses tested. The Panel considered that no additional toxicological studies are required on the nutrient source. The intervention study in healthy infants provided by the applicant did not indicate differences in growth and tolerance parameters in infants who consumed either an infant formula supplemented with calcium L-methylfolate or with folic acid, and did not raise concerns regarding safety or tolerability of the infant formula with the proposed nutrient source. The study also provided further supporting evidence for the bioavailability of calcium L-methylfolate. The Panel considers that calcium L-methylfolate is a source from which folate is bioavailable and concludes that calcium L-methylfolate is safe under the proposed uses and use levels for infants and young children. A and Knutsen HK, 2020. Scientific Opinion on calcium L-methylfolate as a source of folate added for nutritional purposes to infant and follow-on formula, baby food and processed cerealbased food.

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Section: Information On Existing Evaluations and Authorisationsmentioning

confidence: 99%

Section: Combined Intake From the Nutrient Source And Other Sourcesmentioning

confidence: 99%

Section: Nutritional Informationmentioning

confidence: 99%

See 1 more Smart Citation

Calcium l‐methylfolate as a source of folate added for nutritional purposes to infant and follow‐on formula, baby food and processed cereal‐based food

Turck¹,

Castenmiller²,

Henauw³

et al. 2020

EFS2

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“…In a previous opinion (EFSA NDA Panel, 2014i), the Panel proposed a PRI for folate for adults of 330 µg dietary folate equivalents (DFE) per day. As there is evidence that natural food folates have a lower bioavailability than folic acid, DFE have been introduced in order to account for these differences and were defined as 1 µg DFE = 1 µg food folate = 0.6 µg folic acid from fortified food or as a supplement consumed with food = 0.5 µg of a folic acid supplement taken on an empty stomach.…”

Section: Folatementioning

confidence: 99%

Scientific Opinion on the essential composition of total diet replacements for weight control

Products¹

2015

EFSA Journal

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the essential composition of total diet replacements for weight control. Total diet replacements for weight control are intended to induce a substantial energy deficit in overweight or obese adults who wish to lose weight and replace the whole diet in the context of energyrestricted diets for weight reduction. In this opinion, the Panel proposed a minimum protein content based on a Population Reference Intake for protein adjusted for the overweight or obese (75 g/day), a minimum carbohydrate content based on the obligatory glucose demands of the brain (30 g/day) and minimum contents of linoleic acid (11 g/day), α-linolenic acid (1.4 g/day) and micronutrients based on reference values established either by the Panel or by other scientific or authoritative bodies. Derived from the minimum content of macronutrients, the Panel proposed a minimum energy content of total diet replacements for weight control of 2 510 kJ/day (600 kcal/day). The Panel also advised on potential conditions and restrictions of use for these products. © European SUMMARYFollowing a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the essential composition of total diet replacements for weight control. Total diet replacements for weight control are intended to induce a substantial energy deficit in overweight or obese adults who wish to lose weight and replace the whole diet in the context of energy-restricted diets for weight reduction.The guiding principle for providing advice on the essential composition of total diet replacements for weight control should be that products are safe and suitable when consumed as a sole source of nutrition for several weeks to months by overweight or obese adults in the context of energy-restricted diets for weight reduction. In order to avoid nutrient deficiencies, these products should, therefore, provide at least the Population Reference Intake or the Adequate Intake for adults of all indispensable nutrients. As Dietary Reference Values are generally established for healthy, normal-weight individuals, specific consideration has been given by the Panel in this opinion whether there was an increase in nutrient requirements in the overweight or obese or (rapid) weight loss leads to an increased nutrient loss and thus a higher requirement. The Panel also considered the extent to which different diet compositions impact on losses in fat-free mass, and on other adverse effects of weight loss diets, such as gallstone formation. The effectiveness of a product in terms of extent of weight loss was not in itself considered an appropriate determinant for the necessary composition of total diet replacements for weight control. ProteinThe Population Reference Intake of 0.83 g/kg body weight per day cannot be directly applied to overweight or obese indi...

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“…There is a close metabolic interaction with folate, which has led to the "methyl-trap hypothesis" (Shane and Stokstad, 1985;EFSA NDA Panel, 2014). Cobalamin and folate are linked via the enzyme methionine synthase, which converts 5-methyltetrahydrofolate (5-methyl-THF) to tetrahydrofolate (THF) which is needed in one-carbon metabolism.…”

mentioning

confidence: 99%

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for cobalamin (vitamin B12)

2015

EFSA Supporting Publications

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Scientific Opinion on Dietary Reference Values for folate

Cited by 106 publications

References 228 publications

Calcium l‐methylfolate as a source of folate added for nutritional purposes to infant and follow‐on formula, baby food and processed cereal‐based food

Calcium l‐methylfolate as a source of folate added for nutritional purposes to infant and follow‐on formula, baby food and processed cereal‐based food

Scientific Opinion on the essential composition of total diet replacements for weight control

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for cobalamin (vitamin B12)

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