Scintigraphic Diagnosis of Intrathoracic Splenic Implants Masquerading as Malignancy

Rodrigue, Paul; Fakhri, Asif Ali; Lim, Jeehyun

doi:10.2967/jnmt.116.178616

Cited by 4 publications

(6 citation statements)

References 5 publications

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“…There are anecdotal case reports and series describing thoracic splenosis. [1][2][3][4][5] The concept is clear-if there is injury and splenic rupture along with a tear of the diaphragm, splenic tissue can migrate into the thorax and grow. Only one case of thoracic splenosis without a diaphragmatic rupture has been reported, suggesting haematogenous spread.…”

Section: Discussionmentioning

confidence: 99%

“…Splenic rupture is known to lead to fragments of splenic tissue spreading within the thorax and the abdomen, remaining stable or growing minimally and usually presenting many years later with a diagnostic conundrum. [1][2][3][4] This is one such case. THE CASE A 45-year-old man from a troubled African nation was referred on an urgent basis for a computed tomography (CT)-guided biopsy of 'masses' in the chest.…”

Section: Introductionmentioning

confidence: 98%

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Thoracic splenosis: A curious case of thoracic masses

JANKHARIA¹

2022

NMJI

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Thoracic splenosis: A curious case of thoracic masses

JANKHARIA¹

2022

NMJI

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“…MRI has higher spatial resolution as compared to scintigraphy studies. 8,9 Hypervascular nodular hepatic lesions are most commonly hemangioma, hepatic metastases, hepatic adenoma, focal nodular hyperplasia, and hepatocellular carcinoma. 7 Strictly peripheral lesions in the hepatic parenchyma with peritoneal deposits in a patient with absent spleen should warrant differential diagnosis of splenosis.…”

Section: Role Of Imagingmentioning

confidence: 99%

Hepatic Splenosis: A Rare Entity and Great Mimicker

2022

Journal of Gastrointestinal and Abdominal Radiology

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Splenosis is a benign and rare condition that is usually caused by trauma or splenectomy or other procedures involving splenic tissue. The patient is usually asymptomatic and often diagnosed incidentally especially when presents as intrahepatic lesion, can be misdiagnosed as neoplasm. Here, we present case report of a 56-year-old male patient, who was incidentally detected to have focal liver lesion on routine ultrasound check up. He was further evaluated with computed tomography (CT) and magnetic resonance imaging (MRI) and the lesion was indistinguishable from neoplastic lesions and misdiagnosed to be hepatic adenoma. Retrospectively analyzing, the patient had history of splenectomy following road traffic accident 10 years before the present presentation. Following laparotomy, the liver lesion was resected and histopathology confirmed the diagnosis of hepatic splenosis. In this case report and review, we present the diagnostic features and the criteria that help in the diagnosis of splenosis which is a great mimicker.

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“…The radiological and pathological literature report that approximately 75% of splenules are located in the splenic hilum, 20% near or in the pancreatic tail, and 5% in other regions. Cases of splenules found in the pelvis, groin, gonads, kidneys, adrenal glands, gastrosplenic ligament, liver, gastric wall, intestinal wall, omentum, and mesentery, as well lungs have been reported [2,4,[8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Ferumoxytol-enhanced MR imaging for differentiating intrapancreatic splenules from other tumors

et al. 2020

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Objectives Ferumoxytol is an ultra-small superparamagnetic iron oxide (USPIO) agent that is taken up by splenic tissue. This study describes our initial institutional experience of ferumoxytol-enhanced MRI (feMRI) for differentiating intrapancreatic splenules (IPS) from other pancreatic lesions. Methods In this retrospective study, patients with computed tomographic imaging that identified small enhancing lesions in the tail of the pancreas subsequently underwent feMRI for further characterization. The feMRI protocol included T2-weighted (T2w) imaging with and without fat suppression (FS), R2* mapping, diffusion-weighted imaging (DWI), and T1-weighted (T1w) imaging with FS, prior to contrast injection. Immediately after slow intravenous infusion with 3 mg/kg body weight ferumoxytol, T1w was repeated. Delayed imaging with all sequences were obtained 24–72 h after ferumoxytol administration. Results Seven patients underwent feMRI. In two patients, the pancreatic lesions were presumed as pancreatic neuroendocrine tumor (PNET) from feMRI and in the remaining 5 IPS. One of the two patients with PNET was symptomatic for NET. In another symptomatic patient with pathologically proven duodenal NET and suspected PNET, the pancreatic lesion was proven to be an IPS on feMRI. IPS demonstrated strong negative enhancement in feMRI on T2w and increased R2* values consistent with splenic tissue, while the presumed PNETs did not enhance. T2w FS was helpful on the pre-contrast images to identify IPS, while R2* did on post-contrast images. Neither DWI nor T1w contributed to differentiating PNETs from IPS. Conclusions This study demonstrates the potential utility of feMRI as a helpful adjunct diagnostic tool for differentiating IPS from other pancreatic lesions. Further studies in larger patient cohorts are needed.

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Scintigraphic Diagnosis of Intrathoracic Splenic Implants Masquerading as Malignancy

Cited by 4 publications

References 5 publications

Thoracic splenosis: A curious case of thoracic masses

Thoracic splenosis: A curious case of thoracic masses

Hepatic Splenosis: A Rare Entity and Great Mimicker

Ferumoxytol-enhanced MR imaging for differentiating intrapancreatic splenules from other tumors

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