Scintigraphic Imaging of Renal Function

Peters, A. M.

doi:10.1159/000020547

Cited by 14 publications

(4 citation statements)

References 25 publications

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“…Several methods have been proposed to estimate tissue perfusion in vivo on humans that will provide important information about the organ function. The current method for perfusion measurement relies on scintigraphic imaging (1) to visualize the outcome of a radiotracer injected intravenously. Positron emission tomography (PET) imaging has recently been validated for quantitative (www.interscience.wiley.com) DOI:10.1002/nbm.1397 measurement of renal blood flow (2).…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry

Dragonu¹,

Oliveira²,

Laurent

et al. 2009

NMR in Biomedicine

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A method is proposed for estimating the perfusion rate, thermal diffusivity, and the absorption coefficient that influence the local temperature during high intensity focused ultrasound (HIFU) thermotherapy procedures. For this purpose, HIFU heating experiments (N = 100) were performed ex vivo on perfused porcine kidney (N = 5) under different flow conditions. The resulting spatio-temporal temperature variations were measured non-invasively by rapid volumetric MR-temperature imaging. The bio-heat transfer (BHT) model was adapted to describe the spatio-temporal evolution of tissue temperature in the cortex. Absorption and perfusion coefficients were determined by fitting the integrated thermal load (spatial integration of the thermal maps) curves in time with an analytical solution of the BHT equation proposed for single point HIFU heating. Thermal diffusivity was determined independently by analyzing the spatial spread of the temperature in time during the cooling period. Absorption coefficient and thermal diffusivity were found to be independent of flow, with mean and average values of 11.0 +/- 1.85 mm(3) x K x J(-1) and 0.172 +/- 0.003 mm(2) x s(-1), respectively. A linear dependence of the calculated perfusion rate with flow was observed with a slope of 9.20 +/- 0.75 mm(-3). The perfusion was found to act as a scaling term with respect to temperature but with no effect on the spatial spread of temperature which only depends on the thermal diffusivity. All results were in excellent agreement with the BHT model, indicating that this model is suitable to predict the evolution of temperature in perfused organs. This quantitative approach allows for determination of tissue thermal parameters with excellent precision (within 10%) and may thus help in quantifying the influence of perfusion during MR guided high intensity focused ultrasound (MRgHIFU).

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Section: Introductionmentioning

confidence: 99%

Non‐invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry

Dragonu¹,

Oliveira²,

Laurent

et al. 2009

NMR in Biomedicine

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“…In transplanted kidneys, alterations of renal perfusion might indicate acute allograft rejection or acute tubular necrosis. The clinical state of the art for this application is renal perfusion scintigraphy (1). A renal perfusion scan entails administration of a radiotracer into the blood stream and detection of the radiotracer on a gamma scintillation camera as the tracer flows through the renal artery and is taken up in the kidney and is subsequently washed out into the urinary tract.…”

mentioning

confidence: 99%

FAIR true‐FISP perfusion imaging of the kidneys

Martirosian

Klose

Mader

et al. 2004

Magnetic Resonance in Med

179

237

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“…When correlated CT data are available, they also can be used to define the size and shape of target regions, and thereby compensate the image of the apparent distribution of activity for partial volume errors caused by the finite spatial resolution of the radionuclide imaging system [32]. Therefore, while it often is noted in the scientific literature that SPECT is not quantitative [97][98][99][100] and suffers both accuracy and precision errors, it increasingly is being recognized that SPECT/ CT with appropriate reconstruction algorithms can compensate the radionuclide data for photon attenuation, partial volume errors, and scatter radiation [29,76,82,[94][95][96]101] in a way that significantly improves the accuracy of radionuclide quantitation in comparison to measurements obtained with SPECT alone.…”

Section: Quantitative Accuracy With Spect/ctmentioning

confidence: 99%

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

Seo

Marì

Hasegawa

2008

Seminars in Nuclear Medicine

172

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SPECT/CT has emerged over the past decade as a means of correlating anatomical information from CT with functional information from SPECT. The integration of SPECT and CT in a single imaging device facilitates anatomical localization of the radiopharmaceutical to differentiate physiological uptake from that associated with disease and patient-specific attenuation correction to improve the visual quality and quantitative accuracy of the SPECT image. The first clinically available SPECT/CT systems performed emission-transmission imaging using a dual-headed SPECT camera and a low-power x-ray CT sub-system. Newer SPECT/CT systems are available with high-power CT sub-systems suitable for detailed anatomical diagnosis, including CT coronary angiography and coronary calcification that can be correlated with myocardial perfusion measurements. The high-performance CT capabilities also offer the potential to improve compensation of partial volume errors for more accurate quantitation of radionuclide measurement of myocardial blood flow and other physiological processes and for radiation dosimetry for radionuclide therapy. In addition, new SPECT technologies are being developed that significantly improve the detection efficiency and spatial resolution for radionuclide imaging of small organs including the heart, brain, and breast, and therefore may provide new capabilities for SPECT/CT imaging in these important clinical applications.

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Scintigraphic Imaging of Renal Function

Cited by 14 publications

References 25 publications

Non‐invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry

Non‐invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry

FAIR true‐FISP perfusion imaging of the kidneys

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

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