2024
DOI: 10.1101/2024.07.09.602633
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scKEPLM: Knowledge enhanced large-scale pre-trained language model for single-cell transcriptomics

Yang Li,
Guanyu Qiao,
Guohua Wang

Abstract: The success of large-scale pre-trained language models in the Natural Language Processing (NLP) domain has encouraged their adoption in genomics and single-cell biology. Developing pre-trained models using the rapidly growing single-cell transcriptomic data helps to unravel the intricate language of cells. However, current single-cell pre-trained models primarily focus on learning gene and cell representations from extensive gene expression data, failing to fully comprehend the biological significance of the g… Show more

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