Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin-1 in cervical cancer cells

Zhang, Ting; Wang, Ting; Cai, Peiling

doi:10.3892/mmr.2017.6480

Cited by 36 publications

(25 citation statements)

References 35 publications

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“…The bioactivities of some compounds of the essential oil identified from the leaves of V. rotundifolia in this study have been documented in previous studies [ZHANG et al, 2017] .…”

Section: Resultssupporting

confidence: 73%

Chemical constituents and antibacterial activity of essential oil of Vitex rotundifolia from Southern Vietnam

Van¹,

Tran²,

Ton³

et al. 2020

bjbabe

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In present study, we identified the chemical composition of essential oil which was isolated from the leaves of Vitex rotundifolia using gas chromatography-mass spectrometry (GC-MS) analysis for the first time. A total of eighteen compounds were identified from essential oil, including sclareol (29.01 %); sandaracopimarinal (16.51 %); abietadiene (15.65 %); androsta-4,6dien-3-one, 17-hydroxy-, (17β)-(8.12 %); abietal (6.45 %); dehydroabietan (5.02 %); verticiol (4.89 %) as major constituents. Furthermore, the antibacterial activity of the essential oils isolated from of the leaves of studied species has also been evaluated in the first time. The results proved that the essential oils could inhibit the growth of six pathogenic bacterial strains which the diameter of the growth inhibition zone of S.

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“…The bioactivities of some compounds of the essential oil identified from the leaves of V. rotundifolia in this study have been documented in previous studies [ZHANG et al, 2017] .…”

Section: Resultssupporting

confidence: 73%

Chemical constituents and antibacterial activity of essential oil of Vitex rotundifolia from Southern Vietnam

Van¹,

Tran²,

Ton³

et al. 2020

bjbabe

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“…It has been reported that genetic changes of Cav1 might modify the risk for breast cancer,151 and Cav1 acts both as a tumor suppressor as well as an oncogene, and plays a key role in breast cancer tumorigenesis 152. In addition to breast cancer carcinogenic process, Cav1 is also associated with lung cancer,153,154 colorectal cancer,155 gastric cancer,156,157 cervical cancer,158 hepatocellular carcinoma,159 pancreatic cancer,160 bladder cancer,161 pulmonary hypertension,162–164 virus infection,165,166 cardiovascular disease,167,168 diabetes mellitus,169 nanomedicines endocytosis170 and lipodystrophy 171. Besides, it has been reported that caveo-lin-2 (Cav2) can also mediate the initiation and development of breast cancer 26…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

<p>Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment</p>

Qian

Pan

Huang

et al. 2019

OTT

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Human breast cancer is one of the most frequent cancer diseases and causes of death among female population worldwide. It appears at a high incidence and has a high malignancy, mortality, recurrence rate and poor prognosis. Caveolin-1 (Cav1) is the main component of caveolae and participates in various biological events. More and more experimental studies have shown that Cav1 plays a critical role in the progression of breast cancer including cell proliferation, apoptosis, autophagy, invasion, migration and breast cancer metastasis. Besides, Cav1 has been found to be involved in chemotherapeutics and radiotherapy resistance, which are still the principal problems encountered in clinical breast cancer treatment. In addition, stromal Cav1 may be a potential indicator for breast cancer patients' prognosis. In the current review, we cover the state-of-the-art study, development and progress on Cav1 and breast cancer, altogether describing the role of Cav1 in breast cancer progression and application in clinical treatment, in the hope of providing a basis for further research and promoting CAV1 gene as a potential target to diagnose and treat aggressive breast cancers.

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“…Although several labdane diterpenoids such as sclareol, coronarin D, andrographolide, and selected hispanolone derivatives have been described to exhibit potent antitumor activities via induction of apoptosis (Mahaira et al, 2011; Lim et al, 2012; Traves et al, 2013; Mishra et al, 2015; Mota et al, 2015; Wang et al, 2015; Zhang et al, 2017), few data have been reported regarding their role on cell migration. Indeed, to the best of our knowledge, this is the first study describing the anti-invasiveness properties of hispanolone derivatives on glioblastoma tumors.…”

Section: Discussionmentioning

confidence: 99%

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

et al. 2019

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α-Hispanolol (α-H) is a labdane diterpenoid that has been shown to induce apoptosis in several human cancer cells. However, the effect of α-H in human glioblastoma cells has not been described. In the present work, we have investigated the effects of α-H on apoptosis, migration, and invasion of human glioblastoma cells with the aim of identifying the molecular targets underlying its mechanism of action. The results revealed that α-H showed significant cytotoxicity against human glioma cancer cell lines U87 and U373 in a concentration- and time-dependent manner. This effect was higher in U87 cells and linked to apoptosis, as revealed the increased percentage of sub-G1 population by cell cycle analysis and acquisition of typical features of apoptotic cell morphology. Apoptosis was also confirmed by significant presence of annexin V-positive cells and caspase activation. Pretreatment with caspase inhibitors diminishes the activities of caspase 8, 9, and 3 and maintains the percentage of viable glioblastoma cells, indicating that α-H induced cell apoptosis through both the extrinsic and the intrinsic pathways. Moreover, we also found that α-H downregulated the anti-apoptotic Bcl-2 and Bcl-xL proteins and activated the pro-apoptotic Bid and Bax proteins. On the other hand, α-H exhibited inhibitory effects on the migration and invasion of U87 cells in a concentration-dependent manner. Furthermore, additional experiments showed that α-H treatment reduced the enzymatic activities and protein levels of matrix metalloproteinase MMP-2 and MMP-9 and increased the expression of TIMP-1 inhibitor, probably via p38MAPK regulation. Finally, xenograft assays confirmed the anti-glioma efficacy of α-H. Taken together, these findings suggest that α-H may exert anti-tumoral effects in vitro and in vivo through the inhibition of cell proliferation and invasion as well as by the induction of apoptosis in human glioblastoma cells. This research describes α-H as a new drug that may improve the therapeutic efficacy against glioblastoma tumors.

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Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin-1 in cervical cancer cells

Cited by 36 publications

References 35 publications

Chemical constituents and antibacterial activity of essential oil of Vitex rotundifolia from Southern Vietnam

Chemical constituents and antibacterial activity of essential oil of Vitex rotundifolia from Southern Vietnam

<p>Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment</p>

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

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