Sclerotherapy with bleomycin does not adversely affect facial nerve function in children with cervicofacial cystic lymphatic malformation

Karavelioğlu, Afra; Temuçin, Çağrı Mesut; Tanyel, Feridun Cahit; Çiftçi, Arbay Ö.; Şenocak, Mehmet Emìn; Karnak, İbrahìm

doi:10.1016/j.jpedsurg.2009.12.014

Cited by 21 publications

(10 citation statements)

References 17 publications

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“…ST was embraced as an alternative treatment method and almost replaced surgery during the last decade. Unlike surgery, it is easy, scar-less, and not associated with neurovascular complications [13]. ST therefore seems to be a good alternative to open surgery and laparoscopy [14].…”

Section: Discussionmentioning

confidence: 99%

Sclerotherapy with bleomycin versus surgical excision for extracervical cystic lymphatic malformations in children

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Sclerotherapy with bleomycin versus surgical excision for extracervical cystic lymphatic malformations in children

et al. 2015

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“…Considering that the lesions in this series were located in the deep facial tissue, care should be taken not to damage the nerve. Fortunately as reported by Karavelioglu et al, [32] subcutaneous injection of pingyangmycin did not cause facial nerve palsy. No other severe complications, such as pulmonary fibrosis, gastrointestinal reaction, and acute allergic reactions, occurred after treatment due to the control of concentration and dosage.…”

Section: Discussionmentioning

confidence: 55%

Treatment of deep-seated facial microcystic lymphatic malformations with intralesional injection of pingyangmycin

Wang²,

Zheng

et al. 2016

Medicine

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Treatment of microcystic lymphatic malformations (LMs) is still a great challenge to physicians in the field of managing vascular anomalies. Several kinds of treatment have been proposed for microcystic LMs, but the responses to these treatment modalities vary considerably among individuals. The aim of the study was to investigate the safety and efficacy of intralesional injection of pingyangmycin for microcystic LMs located in the deep facial region.Twenty-one consecutive patients with deep-seated facial microcystic LMs were treated with intralesional injection of pingyangmycin between March 2010 and April 2015. The patients received 2 to 8 injections, and the average session was 3.7. The therapeutic efficacy was accessed on the basis of the imaging findings and clinical measurements.Among the 21 patients, the clinical responses were excellent in 7 patients (33.33%), good in 9 patients (42.86%), fair in 3 patients (14.29%), and poor in 2 patients (9.52%). No severe side effects were encountered. Furthermore, therapeutic outcomes were significantly associated with lesion location (P = 0.006) and number of injections (P = 0.003).Our study supports that sclerotherapy with pingyangmycin is safe and effective for the treatment of deep-seated facial microcystic LMs.

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“…4 Cerrahi eksizyon sonrasında gelişebilen fasiyal sinir hasarı da bleomisin enjeksiyonu sonrası görülmez. 5 Bleomisinin etkinliğinde lenfanjiyomun büyüklüğü ve tipi önemlidir. Makrokistlerde başarı oranı mikrokistlere göre daha yüksektir.…”

Section: Discussionunclassified

A Rare Diagnosis in an Infant with Upper Airway Obstruction: Lymphangioma

Aslan¹,

Arslan²,

Horoz³

et al. 2017

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GirişLenfanjiyom, lenfatik sistemin doğuştan malformasyonudur ve yenidoğan döneminde baş ve boyun bölgesinin en sık görülen doğuştan kistik malformasyonlardan biridir.1 Lenfatik damarlarla venöz sistem arasında nedeni bilinmeyen bir nedenle bağlantının oluşmaması sonucu gelişir. Çocukluk çağının en sık görülen ikinci benign vasküler tümörüdür ve %50'si doğumda %90'ı da 2 yaşın altında tanı alır.2 Uzun yıllar temel tedavi olarak cerrahi eksizyon uygulanmasına rağmen komşuluğundaki önemli anatomik dokulara invaze olduğunda eksizyonu zordur ve nüks, skar, enfeksiyon gibi komplikasyonlarından dolayı seçenek tedavi arayışlarına neden olmuştur. Son yıllarda kullanılan yeni tedavi seçenekleri arasında öne çıkan bleomisin ve picibanil (OK-432) gibi sklerozan ajanların intralezyonel enjeksiyonları ile başarılı sonuçlar bildirilmektedir.3 Özellikle bleomisin yaygın olarak kullanılmaktadır ve yan etkisi oldukça azdır. Lenfanjiyom ani solunum sıkıntısına yol açması yönüyle de önem taşımaktadır. Biz burada üst hava yolu obstrüksiyonu nedeni ile başvurup acil trakeostomi açılan olguyu sunduk ve zor havayoluna yol açan bu nadir nedene ve cerrahiye seçenek olan tedavi yöntemlerine dikkat çekmek istedik.

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Sclerotherapy with bleomycin does not adversely affect facial nerve function in children with cervicofacial cystic lymphatic malformation

Cited by 21 publications

References 17 publications

Sclerotherapy with bleomycin versus surgical excision for extracervical cystic lymphatic malformations in children

Sclerotherapy with bleomycin versus surgical excision for extracervical cystic lymphatic malformations in children

Treatment of deep-seated facial microcystic lymphatic malformations with intralesional injection of pingyangmycin

A Rare Diagnosis in an Infant with Upper Airway Obstruction: Lymphangioma

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