Scopoletin

Abstract

Cancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and radiotherapy, have been hampered by their side effects. Natural product-derived plants have been used for decades to treat diseases. Compared to conventional therapy, natural product has the potential to be effective against cancer with fewer side effects. This current review discussed the potential of scopoletin, a coumarin present in many edible plants, which elicits anticancer properties through multiple mechanisms, including modulating cell cycle arrest, inducing apoptosis, and regulating multiple signaling pathways. Understanding these mechanisms highlights the potential of scopoletin as a candidate for chemoprevention and chemotherapy.

Nutritive value, biological properties, health benefits and applications of Tetrapleura tetraptera: An updated comprehensive review

“…T. tetraptera has about 295.97 μg/g of rutin available in the fruit [ 28 ] presenting the plant with significant anticancer activity. Also, scopoletin (a coumarin available in various edible plants) presents anticancer activity via multiple mechanisms like modulating cell cycle arrest, inducing apoptosis, and regulating multiple signaling pathways [ 72 ]. T. tetraptera possesses scopoletin, which is significant in conferring anticancer properties [ 72 , 73 ].…”

“…Also, scopoletin (a coumarin available in various edible plants) presents anticancer activity via multiple mechanisms like modulating cell cycle arrest, inducing apoptosis, and regulating multiple signaling pathways [ 72 ]. T. tetraptera possesses scopoletin, which is significant in conferring anticancer properties [ 72 , 73 ]. People susceptible to certain types of cancer may benefit from scopoletin obtained from the application of T. tetraptera extracts.…”

Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity

“…The antitumor activity of scopoletin may result from its antiproliferation, anti-migration, pro-apoptotic, anti-invasion, and antiangiogenic inhibition of multiple drug resistance, regulation of the mitogen-activated protein kinase (MAPK) and PI3K/AKT/mTOR pathways, and its effect on cell cycle arrest (Antika et al, 2023).…”

Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3

“…Other bioactive compounds like tomentosin, a terpenoid isolated from plants of the Asteraceae family such as Inula viscosa, and jolkinolide B (extracted from Euphorbia kansui) inhibit the proliferation and migratory activity of cancer cells by downregulating the PI3K-Akt pathway and the expression of certain proinfammatory genes [17][18][19]. Meilawati et al [20] have shown that scopoletin, a coumarin present in most edible plants, exerts its anticancer activities through multiple mechanisms including the modulation of cell cycle arrest, the induction of apoptosis, and the regulation of multiple signaling pathways. Tus, Acmella caulirhiza, a fowering plant belonging to the Asteraceae family, is seasonally found in humid tropical areas.…”