SCORE Studies on the Impact of Drug Treatment on Morbidity due to Schistosoma mansoni and Schistosoma haematobium Infection

King, Charles H.; Binder, Sue; Shen, Ye; Whalen, Christopher C.; Campbell, Carl H.; Wiegand, Ryan E.; Olsen, Annette; Secor, W. Evan; Montgomery, Susan P.; Musuva, Rosemary; Mwinzi, Pauline N. M.; Magnussen, Pascal; Kinung’hi, Safari; Andrade, Gisele Nepomuceno de; Ezeamama, Amara E.; Colley, Daniel G.

doi:10.4269/ajtmh.19-0830

Cited by 14 publications

(11 citation statements)

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“… 10 Their results are described in further detail in a separate article in this issue. 19 A subset of communities in the gaining control studies were also used for the companion studies of intermediate host snail abundance and infection 20 and the influence of MDA on population genetics of the respective Schistosoma parasites. 21 …”

Section: Schistosomiasis Consortium For Operational Research and Evalmentioning

confidence: 99%

Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa

King

Kittur

Binder

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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This report summarizes the design and outcomes of randomized controlled operational research trials performed by the Bill & Melinda Gates Foundation-funded Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) from 2009 to 2019. Their goal was to define the effectiveness and test the limitations of current WHOrecommended schistosomiasis control protocols by performing large-scale pragmatic trials to compare the impact of different schedules and coverage regimens of praziquantel mass drug administration (MDA). Although there were limitations to study designs and performance, analysis of their primary outcomes confirmed that all tested regimens of praziquantel MDA significantly reduced local Schistosoma infection prevalence and intensity among school-age children. Secondary analysis suggested that outcomes in locations receiving four annual rounds of MDA were better than those in communities that had treatment holiday years, in which no praziquantel MDA was given. Statistical significance of differences was obscured by a wider-than-expected variation in community-level responses to MDA, defining a persistent hot spot obstacle to MDA success. No MDA schedule led to elimination of infection, even in those communities that started at low prevalence of infection, and it is likely that programs aiming for elimination of transmission will need to add supplemental interventions (e.g., snail control, improvement in water, sanitation and hygiene, and behavior change interventions) to achieve that next stage of control. Recommendations for future implementation research, including exploration of the value of earlier program impact assessment combined with intensification of intervention in hot spot locations, are discussed.

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Section: Schistosomiasis Consortium For Operational Research and Evalmentioning

confidence: 99%

Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa

King

Kittur

Binder

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“…The protocols for the large field intervention studies specified the outcomes of interest, for example, comparison, by arm, of changes in prevalence and intensity among 9-to 12-year-old schoolchildren in the gaining and sustaining control and Zanzibar elimination studies, and a variety of biometric and other health indicators in the morbidity cohort studies. 10,32 In addition, a UGA statistician developed more rigorous plans, for example, describing the specific statistical tests that would be used to compare performance of arms and addressing issues related to multiple comparisons.…”

Section: Measurement and Analysis Of Outcomesmentioning

confidence: 99%

The Schistosomiasis Consortium for Operational Research and Evaluation 2008–2020: Approaches, Experiences, Lessons, and Recommendations

Binder

Campbell

Andros

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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For the past 10 years, the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), funded by the Bill & Melinda Gates Foundation, has been supporting operational research to provide a stronger evidence base for controlling and moving toward elimination of schistosomiasis. The SCORE portfolio was developed and implemented with engagement from many stakeholders and sectors. Particular efforts were made to include endemic country neglected tropical disease program managers. Examples of the challenges we encountered include the need to balance rigor (e.g., conducting large cluster-randomized trials) with ensuring relevance to real-world settings, allowing for local contexts while standardizing key study aspects, adjusting to evolving technologies, and incorporating changing technologies into multiyear studies. The Schistosomiasis Consortium for Operational Research and Evaluation's findings and data and the collected specimens will continue to be useful in the years to come. Our experiences and lessons learned can benefit both program managers and researchers conducting similar work in the future.

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“…Nested cohort studies of morbidity were, therefore, embedded within gaining control studies in Kenya, Mozambique, Niger, and Tanzania for this purpose. 8 (SCORE termed these the cohort morbidity studies; see King et al 9 in this issue for details.) 3.…”

Section: Overviewmentioning

confidence: 99%

Challenges in Protocol Development and Interpretation of the Schistosomiasis Consortium for Operational Research and Evaluation Intervention Studies

King

Kittur

Wiegand

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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SCORE Studies on the Impact of Drug Treatment on Morbidity due to Schistosoma mansoni and Schistosoma haematobium Infection

Abstract: which was funded by the Bill & Melinda Gates Foundation for the SCORE project. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.

Cited by 14 publications

References 58 publications

Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa

Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa

The Schistosomiasis Consortium for Operational Research and Evaluation 2008–2020: Approaches, Experiences, Lessons, and Recommendations

Challenges in Protocol Development and Interpretation of the Schistosomiasis Consortium for Operational Research and Evaluation Intervention Studies

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