2023
DOI: 10.1111/cod.14414
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CD100 boosts the inflammatory response in the challenge phase of allergic contact dermatitis in mice

Veronika Mraz,
Anders B. Funch,
Mia H. Jee
et al.

Abstract: BackgroundAllergic contact dermatitis (ACD) is an inflammatory disease with a complex pathophysiology in which epidermal‐resident memory CD8+ T (TRM) cells play a key role. The mechanisms involved in the activation of CD8+ TRM cells during allergic flare‐up responses are not understood.MethodsThe expression of CD100 and its ligand Plexin B2 on CD8+ TRM cells and keratinocytes before and after allergen exposure was determined by flow cytometry and RT‐qPCR. The role of CD100 in the inflammatory response during t… Show more

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