EPA‐coated titanium implants promote osteoconduction in white New Zealand rabbits

Abstract

Objectives: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles.Material and methods: Sandblasted and cleansed planar titanium specimens with a size of 5 9 5 9 1 mm were coated on one side with 0.25 vol% eicosapentaenoic acid (EPA). The other side of the specimens was kept highly polished (the control side). These specimens were inserted in rabbit mandibles. Twelve rabbits were randomly assigned into three study groups (n = 4). The rabbits were sacrificed at 4, 8, and 12 weeks. The harvested specimens with the implants were assessed for new bone formation on both sides of the implant using CBCT, conventional radiographs, and the biaxial pullout test. The results were statistically analyzed by a nonparametric Kruskal-Wallis test and Friedman's test as multiple comparisons and by Brunner-Langer nonparametric mixed model approach (R Software).

Effect of Laser Therapy on the Osseointegration of Immediately Loaded Dental Implants in Patients under Vitamin C, Omega-3 and Calcium Therapy

“…Moreover, this was in line with a study performed on white New Zealand rabbits using implants coated with eicosapentaenoic acid that was shown to enhance osteoconduction and anchorage of the implant to the surrounding bone [ 14 ]. Also, it was in line with a study performed by Park et al, 2007, where the results concluded that Ca and vitamin D supplementation promoted bone healing around dental implants [ 32 ].…”

“…Fish oils are rich sources of the omega-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic (EPA) acid and dexahexaenoic acid (DHA) that are distributed in almost all body cells, thus impacting cell functions, cell communication, production of various biomolecules and antioxidant activities [ 13 ]. Furthermore, decreased bone resorption or enhanced bone formation may be a consequence of the dual bone-sparing effect of omega-3 [ 14 ].…”

A novel nano-copper-bearing stainless steel with reduced Cu2+ release only inducing transient foreign body reaction via affecting the activity of NF-κB and Caspase 3

“…However, these implants can only be termed "mechanical implants" because they lack essential biological properties, such as anti-microbial or osteogenic ability. Therefore, many researchers have performed a lot of studies to improve the biological properties of SS or titanium alloy, including increasing biological coating or adding biological elements, [1][2][3][4][5][6] and have achieved significant progress.…”