<scp>ER</scp> export signals mediate plasma membrane localization of transmembrane protein <scp>TMEM72</scp>

Ding, Jiangli; Matsumiya, Tomoh; Miki, Yasuo; Hayakari, Ryo; Shiba, Yuko; Kawaguchi, Shogo; Seya, Kazuhiko; Imaizumi, Tadaatsu

doi:10.1111/febs.16697

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…However, the relationship between NPHS1 expression and tumor treatment and prognosis has not been reported 23 . TMEM72 is a transmembrane protein involved in the development of normal kidney and renal cell carcinoma, 24 but its role in the development of bladder cancer has not been demonstrated. SRRM4 drives the development of castration‐resistant prostate cancer and is a potential therapeutic target for neuroendocrine prostate cancer 25 .…”

Section: Discussionmentioning

confidence: 99%

Identification of tumor immunophenotypes associated with immunotherapy response in bladder cancer

Liang,

Liao,

Yang

et al. 2023

Int J of Urology

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ObjectivesThis study aims to reveal immunophenotypes associated with immunotherapy response in bladder cancer, identify the signature genes of immune subtypes, and provide new molecular targets for improving immunotherapy response.MethodsBladder cancer immunophenotypes were characterized in the bulk RNA sequencing dataset GSE32894 and Imvigor210, and gene expression signatures were established to identify the immunophenotypes. Expression of gene signatures were validated in single‐cell RNA sequencing dataset GSE145140 and human proteins expression data source. Investigation of Immunotherapy Response was performed in IMvigor210 dataset. Prognosis of tumor immunophenotypes was further analyzed.ResultsInflamed and immune‐excluded immunophenotypes were characterized based on the tumor immune cell scores. Risk score models that were established rely on RNA sequencing profiles and overall survival of bladder cancer cohorts. The inflamed tumors had lower risk scores, and the low‐risk tumors were more likely to respond to atezolizumab, receiving complete response/partial response (CR/PR). Patients who responded to atezolizumab had higher SRRM4 and lower NPHS1 and TMEM72 expression than the non‐responders. SRRM4 expression was a protective factor for bladder cancer prognosis, while the NPHS1 and TMEM72 showed the opposite pattern.ConclusionThis study provided a novel classification method for tumor immunophenotypes. Bladder cancer immunophenotypes can predict the response to immune checkpoint blockade. The immunophenotypes can be identified by the expression of signature genes.

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Section: Discussionmentioning

confidence: 99%

Identification of tumor immunophenotypes associated with immunotherapy response in bladder cancer

Liang,

Liao,

Yang

et al. 2023

Int J of Urology

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Evolutionary history and seascape genomics of Harbour porpoises (Phocoena phocoena) across environmental gradients in the North Atlantic and adjacent waters

Celemín,

Autenrieth,

Roos

et al. 2023

Molecular Ecology Resources

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The Harbour porpoise (Phocoena phocoena) is a highly mobile cetacean species primarily occurring in coastal and shelf waters across the Northern hemisphere. It inhabits heterogeneous seascapes broadly varying in salinity and temperature. Here, we produced 74 whole genomes at intermediate coverage to study Harbour porpoise's evolutionary history and investigate the role of local adaptation in the diversification into subspecies and populations. We identified ~6 million high quality SNPs sampled at eight localities across the North Atlantic and adjacent waters, which we used for population structure, demographic and genotype–environment association analyses. Our results suggest a genetic differentiation between three subspecies (P.p. relicta, P.p. phocoena and P.p. meridionalis), and three distinct populations within P.p. phocoena: Atlantic, Belt Sea and Proper Baltic Sea. Effective population size and Tajima's D suggest population contraction in Black Sea and Iberian porpoises, but expansion in the P.p. phocoena populations. Phylogenetic trees indicate post‐glacial colonization from a southern refugium. Genotype–environment association analysis identified salinity as major driver in genomic variation and we identified candidate genes putatively underlying adaptation to different salinity. Our study highlights the value of whole genome resequencing to unravel subtle population structure in highly mobile species, shows how strong environmental gradients and local adaptation may lead to population differentiation, and how neutral and adaptive markers can give different perspectives on population subdivision. The results have great conservation implications as we found inbreeding and low genetic diversity in the endangered Black Sea subspecies and identified the critically endangered Proper Baltic Sea porpoises as a separate population.

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ER export signals mediate plasma membrane localization of transmembrane protein TMEM72

Cited by 2 publications

References 54 publications

Identification of tumor immunophenotypes associated with immunotherapy response in bladder cancer

Identification of tumor immunophenotypes associated with immunotherapy response in bladder cancer

Evolutionary history and seascape genomics of Harbour porpoises (Phocoena phocoena) across environmental gradients in the North Atlantic and adjacent waters

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