<scp>GC</scp> for flavonoids analysis: Past, current, and prospective trends

Nolvachai, Yada; Marriott, Philip J.

doi:10.1002/jssc.201200846

Cited by 43 publications

(29 citation statements)

References 94 publications

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“…Thus, the analysis of isoflavonoids isolated from seven varieties of red propolis obtained from different regions of Cuba was carried out using a GC‐MS system and seventeen compounds were identified . Moreover, the quantification of flavonoids using GC was in detail presented in a comprehensive review .…”

Section: Analytical Techniques Used For Determination and Quantificatmentioning

confidence: 99%

Extraction approaches used for the determination of biologically active compounds (cyclitols, polyphenols and saponins) isolated from plant material

et al. 2018

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Based on the bioactive properties of certain compounds, such as antioxidant and anti-inflammatory activities, an interesting subject of research are natural substances present in various parts of plants. The choice of the most appropriate method for separation and quantification of biologically active compounds from plants and natural products is a crucial step of any analytical procedure. The aim of this review article is to present an overview of a comprehensive literature study from the last 10 years (2007-2017), where relevant articles exposed the latest trends and the most appropriate methods applicable for separation and quantification of biologically active compounds from plant material and natural products. Consequently, various extraction methods have been discussed, together with the available procedures for purification and pre-concentration and dedicated methods used for analysis.

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Section: Analytical Techniques Used For Determination and Quantificatmentioning

confidence: 99%

Extraction approaches used for the determination of biologically active compounds (cyclitols, polyphenols and saponins) isolated from plant material

et al. 2018

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“…Due to their unique physico‐chemical properties and relevant biological activities, an increasing interest can be observed for the development of new anticancer flavonoid‐based drugs. Flavonoids are a naturally occurring subclass of polyphenols based on a C6‐C3‐C6 phenyl‐benzopyran backbone . The high versatility of the flavonoid scaffold provides them with promiscuous affinity towards a plethora of biological targets, which in turn influence a number of cancer‐related processes, such as cellular proliferation, differentiation, apoptosis, metastasis and reversal of multidrug‐resistance .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity studies, DNA interaction and protein binding of new Al (III), Ga (III) and In (III) complexes with 5‐hydroxyflavone

Arbănași

Badea

Olar

et al. 2018

Applied Organom Chemis

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We report the synthesis and characterization of three new complexes of the natural flavonoid 5-hydroxyflavone (primuletin) and Al (III), Ga (III), In (III), respectively. The physico-chemical properties and structural features of these three novel compounds have been investigated by elemental and thermogravimetric analysis, molar conductance and several spectroscopic techniques, including FT-IR, UV-Vis and mass spectra. Based on the experimental data, the general chemical formula of the complexes iswhere M is the cation and n = 2 for Al (III), n = 0 for Ga (III), n = 1, for In (III); each one of the three 5-hydoxyflavone molecules acts as a monoanionic bidentate chelate ligand in the complexes. DFT calculations further sustain the proposed structures of the complexes. Cytotoxicity was studied using MTS assay on cervical, breast, colon and ovary adenocarcinoma cell lines.The central metal ions exert cytotoxic effects in a disparate manner: Al (III) enhances, while Ga (III) and In (III) decrease the cytotoxicity of the ligand.As a means to investigate the mechanism underlying the cytotoxic effects of the complexes, interactions with calf thymus DNA, human serum albumin and transferrin were also carried out.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…), but the GC‐MS method used in this study was unable to detect flavonoids in ALE, FLE and OLE. Unless the plant parts are extracted with ethyl acetate, derivatized to form trimethylsilyl derivatives of flavonoids and separated, flavonoids cannot be detected and identified by GC‐MS (Zhang and Zuo ; Nolvachai and Marriott ). Hence, thin‐layer chromatography–directed bioautography (TLC‐DB) was used for searching compounds with demonstrable QS‐I activities in ALE, FLE and OLE.…”

Section: Resultsmentioning

confidence: 99%

Prospective bacterial quorum sensing inhibitors from Indian medicinal plant extracts

Tiwary

Ghosh

Moktan

et al. 2017

Letters in Applied Microbiology

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A novel alternative prospect to prevent bacterial infections without inhibiting the growth is to apply chemicals that inhibit quorum sensing mechanism of the pathogens. Antiquorum property of 61 medicinal plants was evaluated by the ability of their leaf extract(s) to inhibit production of pigment (violacein in Chromobacterium violaceum MTCC 2656, pyocyanin in Pseudomonas aeruginosa MTCC 2297) or swarming in P. aeruginosa MTCC 2297. The most prospective plants (for the development of quorum sensing inhibitor), showing inhibition of violacein production without affecting bacterial growth, were Astilbe rivularis, Fragaria nubicola and Osbeckia nepalensis.

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GC for flavonoids analysis: Past, current, and prospective trends

Cited by 43 publications

References 94 publications

Extraction approaches used for the determination of biologically active compounds (cyclitols, polyphenols and saponins) isolated from plant material

Extraction approaches used for the determination of biologically active compounds (cyclitols, polyphenols and saponins) isolated from plant material

Cytotoxicity studies, DNA interaction and protein binding of new Al (III), Ga (III) and In (III) complexes with 5‐hydroxyflavone

Prospective bacterial quorum sensing inhibitors from Indian medicinal plant extracts

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