<scp>Nanofibrous</scp> composite from <scp>polycaprolactone‐polyethylene glycol‐aloe</scp> vera as a promising scaffold for bone repairing

Dehghan, Fateme; Gholipour-Kanani, Adeleh; Dolatabadi, Mehdi Kamali; Bahrami, S. Hajir

doi:10.1002/app.52463

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…3 B, the water contact angle for PCL is about 120°, proposing the very hydrophobic nature of the PCL polymer-based nanofibers. This can be explained by the presence of numerous hydrophobic groups in the structure of the PCL 13 . Contrarily, addition of the PEG in the structure of the PCL-PEG resulted in reduction of the water contact angel to 70° which can be explained by the hydrophilic nature of the PEG polymer 13 .…”

Section: Resultsmentioning

confidence: 99%

“…This can be explained by the presence of numerous hydrophobic groups in the structure of the PCL 13 . Contrarily, addition of the PEG in the structure of the PCL-PEG resulted in reduction of the water contact angel to 70° which can be explained by the hydrophilic nature of the PEG polymer 13 . Regards, a physical crosslinking through the intra-molecular interaction between functional groups of PCL and PEG leads to the integrity of the scaffold in aqueous media.…”

Section: Resultsmentioning

confidence: 99%

“…Poly(ɛ-caprolactone) (PCL) and poly(ethylene glycol) (PEG) are two non-cytotoxic, biocompatible and biodegradable polymers which possess excellent permeability 11 , 12 . Combining biological and mechanical properties of PCL with drug delivery capacity of PEG as a biocompatible lubricant agent were studied in our previous report in which PCL: PEG: Aloe-Vera nanofibers had been fabricated and evaluated for bone repairing application 13 . According to the other reports, the properties of PCL and PEG have turned them in to frequently used raw materials in development of several burn wound care dressings which have succeeded in receiving FDA-approval 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

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Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Shadman-Manesh

Gholipour-Kanani

Najmoddin

et al. 2023

Sci Rep

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Considering the great potential of egg yolk oil (EYO) in management of burn wounds and superb biological properties of polycaprolactone (PCL) and polyethylene glycol (PEG), hereby, a PCL-PEG-EYO scaffold was developed by electrospinning method for burn healing. The physico-chemical characterizations were performed using SEM, FTIR and contact angle tests. The biological properties of the fabricated scaffolds were evaluated by antibacterial test, in vitro cell culturing, MTT assay and in vivo experiments. The SEM images of PCL-PEG-EYO nanofibers demonstrated a uniform bead-free morphology with 191 ± 61 nm diameter. The fabricated scaffold revealed hydrophilicity with the water contact angel of 77°. No cytotoxicity was observed up to 7 days after cell culturing onto the PCL-PEG-EYO nanofibrous surface. The presence of EYO in the PCL-PEG-EYO scaffold meaningfully improved the cell viability, proliferation and attachment compared to PCL-PEG scaffold. Moreover, the PCL-PEG-EYO scaffolds demonstrated antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria strain. Finally, a statistically significant enhancement in wound closure, re-epithelialization, angiogenesis and collagen synthesis was observed at the end of 21-day treatment period using PCL-PEG-EYO nanofibrous scaffold. Overall, the PCL-PEG-EYO nanofibrous scaffolds demonstrated a great potential in management of full thickness burn wounds in vivo.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Shadman-Manesh

Gholipour-Kanani

Najmoddin

et al. 2023

Sci Rep

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“…Plant extracts interact with each other through different biochemical pathways to achieve anti-inflammatory, antioxidant, antifungal, and analgesic effects. Natural plant extracts are a rich treasure trove [ 143 ]. Countless researchers have worked to reveal the relationship and secrets of natural resources such as plants, animals, and even minerals to human health.…”

Section: Electrospinning In the Treatment Of Oral Ulcersmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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“…Riaz et al [ 25 ] introduced PEG into the preparation of PCL nanofibers, which not only reduced the fiber diameter but also improved the crystallinity and wettability of PCL nanofibers. Dehghan et al [ 26 ] prepared PCL/PEG/aloe vera nanofiber scaffolds, and osteoblast-like cells showed good penetration, growth, and proliferation capabilities on them.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release

Pan

Yang

2022

Molecules

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Simvastatin (SIM) particles are liposoluble drugs with large particle sizes, resulting in poor compatibility with electrospun polycaprolactone (PCL)/polyethylene glycol (PEG) nanofibers, so that part of them will be exposed to the electrospun nanofiber surface, which is easy to cause the burst release of drugs. Therefore, in this paper, stearic acid (SA) with good biocompatibility was innovatively added to increase the dispersion uniformity of SIM in the spinning solution, thus improving the performances of SIM-loaded PCL/PEG nanofiber membranes (NFMs). Accordingly, the effects of SA addition on the morphologies, mechanical properties, wettability, and drug release properties of the SIM-loaded NFMs were studied. The results showed that after SIM was dissolved in SA solution, the particle size of SIM was significantly reduced and could be evenly dispersed in the polymer spinning solution, thus obtaining the SIM-loaded composite NFMs with the best morphology and performance.

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Nanofibrous composite from polycaprolactone‐polyethylene glycol‐aloe vera as a promising scaffold for bone repairing

Cited by 8 publications

References 26 publications

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release

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