RNA m6A modifications regulate crosstalk between tumor metabolism and immunity

Abstract

In recent years, m6A modifications in RNA transcripts have arisen as a hot topic in cancer research. Indeed, a number of independent studies have elaborated that the m6A modification impacts the behavior of tumor cells and tumor‐infiltrating immune cells, altering tumor cell metabolism along with the differentiation and functional activity of immune cells. This review elaborates on the links between RNA m6A modifications, tumor cell metabolism, and immune cell behavior, discussing this topic from the viewpoint of reciprocal regulation through “RNA m6A–tumor cell metabolism–immune cell behavior” and “RNA m6A–immune cell behavior–tumor cell metabolism” axes. In addition, we discuss the various factors affecting RNA m6A modifications in the tumor microenvironment, particularly the effects of hypoxia associated with cancer cell metabolism along with immune cell‐secreted cytokines. Our analysis proposes the conclusion that RNA m6A modifications support widespread interactions between tumor metabolism and tumor immunity. With the current viewpoint that long‐term cancer control must tackle cancer cell malignant behavior while strengthening anti‐tumor immunity, the recognition of RNA m6A modifications as a key factor provides a new direction for the targeted therapy of tumors.This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications

N6-methyladenosine modification of hypoxia-inducible factor-1α regulates Helicobacter pylori-associated gastric cancer via the PI3K/AKT pathway

“…Another study indicated that METTL14 interacts with the microprocessor protein DGCR8, promotes the processing and maturation of pri-miRNA126, and inhibits the metastasis of liver cancer[ 17 ]. Furthermore, m6A modification participates in the various aspects of tumor development, such as immunity, metabolism, and tumor stem cells’ self-renewal[ 18 , 19 ], emerging as an important molecular biomarker in tumor initiation and development. m6A dysregulation exerts multiple regulatory effects in GC[ 20 , 21 ].…”