<scp>Single nucleotide polymorphisms</scp> in long noncoding <scp>RNA</scp>,<scp> ANRIL</scp>, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

Schulz, Susanne; Seitter, Linda; Werdan, Karl; Hofmann, Britt; Schaller, Hans‐Günter; Schlitt, Axel; Reichert, Stefan

doi:10.1111/jre.12555

Cited by 16 publications

(9 citation statements)

References 37 publications

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“…Moreover, another study on 22 healthy adults with moderate to severe periodontitis who underwent complete mouth disinfection found that, at one-month follow-up, periodontal treatment resulted in significant improvements in periodontal pocketing, flow-mediated dilation, and serum IL-6, as well as a trend toward reduction in serum CRP [46]. Furthermore, several studies have reported that an intensive periodontal treatment resulted not only in a temporary increase in serum levels of CRP and IL-6, but also in a significant improvement of endothelial dysfunction indexes at six months after active periodontal therapy [47][48][49].…”

Section: Discussionmentioning

confidence: 96%

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133+/KDR+). Furthermore, the objective was to determine if the periodontal status influenced CD133+/KDR+ levels. In all, 88 patients with periodontitis and 79 healthy controls (HCs) were enrolled in the study. Enrolled patients were examined and characterized by clinical and blood sample analysis. Spearman’s correlation test was applied in order to assess the interdependence between CD133+/KDR+ levels and all periodontal parameters. In order to estimate a statistically significant trend (p-trend) for ordered CD133++/KDR+ quartiles, the Jonckheere–Terpstra test was applied for all variables. Patients in the periodontitis group presented significantly lower CD133+/KDR+ levels (66.4 (45.5–269.6 cells/µL)) compared to the HC group (76.7 (24.3–313.2 cells/µL), p < 0.001). Lower CD133+/KDR+ levels negatively correlated with C-reactive protein (CRP), with the number of teeth, and with all periodontal parameters (p < 0.001). Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (p-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, p-trend = 0.003), probing depth (PD, p-trend = 0.007), and bleeding sites (bleeding on probing (BOP), p-trend < 0.001) as an extent measure of periodontitis. This study demonstrated that patients with periodontitis presented significantly lower CD133+/KDR+ levels compared to HCs. Moreover, all patients presented an increase in the CD133+/KDR+ EPC levels with an extended level of periodontitis and tooth loss.

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Section: Discussionmentioning

confidence: 96%

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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“…Групою Poi et al продемонстровано, що в пацієнтів із множинною мієломою, які є гомозиготами ТТ за поліморфним сайтом rs2151280 гена ANRIL, час до розвитку пухлинної прогресії та ускладнень був значно меншим, порівняно із носіями основного С-алеля [9]. Слід також зазначити, що статистичні інструменти для аналізу виживаності в кількох роботах показали, що локуси rs10757278, rs133049 та rs3217992 гена ANRIL є незалежними предикторами розвитку ускладнень серцево-судинних захворювань у пацієнтів із хронічним пародонтитом [20]…”

Section: таблиця 2 вік настання раку сечового міхура залежно від поліunclassified

Analysis of association between genetic polymorphism of long non-coding RNA ANRIL and survival of patients with genitourinary cancer

Volkohon¹,

Harbuzova²,

Атаман³

2020

Buk. Med. Herald

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Мета роботи-вивчення можливого зв'язку виникнення раку нирки та раку сечового міхура із rs4977574-поліморфізмом гена довгої некодуючої РНК ANRIL залежно від віку пацієнтів. Матеріал і методи. Для дослідження використано цільну венозну кров 242 осіб із раком сечостатевої системи (101 пацієнт зі світлоклітинним нирково-клітинним раком та 141 хворий на перехідноклітинний рак сечового міхура). Генотипування за rs4977574-сайтом гена ANRIL здійснювали методом полімеразної ланцюгової реакції в режимі реального часу (Realtime PCR) за наявності TaqMan assay C_31720978_30. Статистично дані опрацьовували за допомогою пакета програм SPSS (версія 17.0). Результати. Встановлено, що в носіїв G-алеля за поліморфним сайтом rs4977574 гена ANRIL злоякісні новоутворення урогенітального тракту виникають приблизно на 5 років раніше, ніж у АА-гомозигот (log rank P = 0,022; Breslow P = 0,006). Результати регресійного аналізу методом Кокса у рамках домінантної моделі успадкування показали, що носії G-алеля мають вищий ризик виникнення раку сечостатевої системи із віком (HR = 1,369; Р = 0,030), порівняно з гомозиготами за основним А-алелем. Достовірність результатів зберігалась і після поправки на стать, індекс маси тіла хворих, наявність у них метастазів, звички палити та вживати алкоголь (HR = 1,348; Р = 0,040). Висновки. Носії G-алеля за rs4977574-поліморфізмом гена довгої некодуючої РНК ANRIL мають вищий ризик виникнення раку сечостатевої системи з віком, порівняно із гомозиготами АА.

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“…In addition to the involvement of antisense RNAs in cardiac diseases via diabetes, antisense transcription/transcripts are also directly associated with cardiovascular diseases. Recent studies have implicated antisense RNAs as new diagnostic markers with therapeutic potentials for cardiovascular diseases [210,211,212,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239]. For example, an antisense transcript H19, discussed above, is associated with cardiovascular diseases such as CAD.…”

Section: Antisense Transcription In Diabetes Cardiovascular and Omentioning

confidence: 99%

“…ANRIL variants (e.g., rs10965215 and rs10738605) resulting from single nucleotide polymorphism (SNP) are associated with the risk of MI in the Chinese Han population [228]. The ANRIL variant rs3217992 has been connected to adverse cardiovascular events [229]. Furthermore, another ANRIL SNP variant, rs10757278, was linked to the development of major adverse cardiovascular events in hemodialysis patients [230].…”

Section: Antisense Transcription In Diabetes Cardiovascular and Omentioning

confidence: 99%

Mechanisms of Antisense Transcription Initiation with Implications in Gene Expression, Genomic Integrity and Disease Pathogenesis

Barman

Reddy

Bhaumik

2019

ncRNA

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Non-coding antisense transcripts arise from the strand opposite the sense strand. Over 70% of the human genome generates non-coding antisense transcripts while less than 2% of the genome codes for proteins. Antisense transcripts and/or the act of antisense transcription regulate gene expression and genome integrity by interfering with sense transcription and modulating histone modifications or DNA methylation. Hence, they have significant pathological and physiological relevance. Indeed, antisense transcripts were found to be associated with various diseases including cancer, diabetes, cardiac and neurodegenerative disorders, and, thus, have promising potentials for prognostic and diagnostic markers and therapeutic development. However, it is not clearly understood how antisense transcription is initiated and epigenetically regulated. Such knowledge would provide new insights into the regulation of antisense transcription, and hence disease pathogenesis with therapeutic development. The recent studies on antisense transcription initiation and its epigenetic regulation, which are limited, are discussed here. Furthermore, we concisely describe how antisense transcription/transcripts regulate gene expression and genome integrity with implications in disease pathogenesis and therapeutic development.

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Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

Abstract: SNPs in ANRIL are not risk modulators for severe periodontitis and history of CVD in CV patients. The AA genotype of ANRIL SNPs rs3217992 possesses prognostic power for further CV events within 3 years of follow-up.

Cited by 16 publications

References 37 publications

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Analysis of association between genetic polymorphism of long non-coding RNA ANRIL and survival of patients with genitourinary cancer

Mechanisms of Antisense Transcription Initiation with Implications in Gene Expression, Genomic Integrity and Disease Pathogenesis

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