“…3,11,22,23,31,32 Mental health is associated with exposure to multiple ACEs, including learning and behavioral problems, somatic disorders, hallucinations, anxiety and obsessivecompulsive disorders, substance use disorders, depression and subsequent suicide attempts during adulthood as well as posttraumatic stress disorder, which may not always respond to traditional treatment. 2,5,[10][11][12][19][20][21]27,28,[33][34][35][36] Previous studies have explored how ACEs create an environment of traumatic toxic stress that can lead to prolonged activation of the stress response system, excess cortisol circulation, and disruption of the neuroendocrine and immune systems. When the stress response system remains on high alert, it can lead to remodeling of neurological pathways particularly in the hippocampus, amygdala, and prefrontal cortex.…”