Screening and profiling stilbene-type natural products with angiotensin-converting enzyme inhibitory activity from Ampelopsis brevipedunculata var. hancei (Planch.) Rehder

Su, Pei-Shiuan; Doerksen, Robert J.; Chen, Sin-Hong; Sung, Wang-Chou; Juan, Chia-Chi; Rawendra, Reynetha D. S.; Chen, Chiy‐Rong; Li, Jiawei; Aisha,; Huang, Tzu‐Chi; Liao, Ming-Huei; Chang, Ching‐Cheng; Hsu, Jue‐Liang

doi:10.1016/j.jpba.2015.01.053

Cited by 17 publications

(19 citation statements)

References 25 publications

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“…In this study, resveratrol showed low ACE inhibitory activity, with inhibition of 41.12%. The result is consistent with the previous study [25]. Su et al 2015 studied ACE inhibitory activity of stilbene from Ampelopsis brevipedunculata var.…”

Section: Ace Inhibition Test and Ic 50 Measurement Testsupporting

confidence: 93%

“…This showed that this plant has potential in ACE inhibition activity. According to literatures, IC 50 value for captopril was 6.87 nM [16]; 1.0 × 10 −11 µg/ml [25]. The difference result of IC 50 value from the literature and another study could be caused by many factors such as the method of experiment, study conditions, enzyme source, and the association between inhibitor and enzyme sources [16].…”

Section: Ace Inhibition Test and Ic 50 Measurement Testmentioning

confidence: 91%

“…This phenomena also showed stilbene from A. brevipedunculata var. hancei [25]. According to the study, tetramer of showed the highest ACE inhibitory binding affinity, followed by that trimer, dimer, and monomer [25].…”

Section: Molecular Dockingmentioning

confidence: 92%

“…Su et al 2015 studied ACE inhibitory activity of stilbene from Ampelopsis brevipedunculata var. hancei [25].…”

Section: Ace Inhibition Test and Ic 50 Measurement Testmentioning

confidence: 99%

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Angiotensin Converting Enzyme Inhibitory Activity of Melinjo (Gnetum Gnemon L.) Seed Extracts and Molecular Docking of Its Stilbene Constituents

Mun’im

Munadhil²,

Puspitasari³

et al. 2017

Asian J Pharm Clin Res

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Objectives: To evaluate the angiotensin converting enzyme (ACE) inhibitory activity of melinjo (Gnetum gnemon) seed extract and to study molecular docking of stilbene contained in melinjo seeds. Methods:Melinjo seed powders were extracted with n-hexane, dichloromethane, ethyl acetate, methanol, and water successively. The extracts were evaluated ACE inhibitory activities using ACE kit-Wist and the phenolic content using Folin-Ciocalteu method. The extract demonstrated the highest ACE inhibitory activity was subjected to liquid chromatography-mass spectrometry (LC-MS) to know its stilbene constituent. The stilbene constituents in melinjo seed were performed molecular docking using AutoDock Vina, and ligand-receptor Interactions were processed using Ligand Scout. Results:The ethyl acetate extract demonstrated the highest ACE inhibition activity with inhibitory concentration 50% value of 9.77 × 10 −8 μg/mL and the highest total phenolic content (575.9 mg gallic acid equivalent/g). Ultra-performance LC-MS analysis of ethyl acetate extract has detected the existency of resveratrol, gnetin C, ε-viniferin, and gnemonoside A/B. These compounds displayed similar physiochemical properties to lisinopril (ACE inhibitor), as in silico molecular docking studies demonstrated that they fit into the lisinopril receptors. Conclusion:In vitro analysis ethyl acetate extract from melinjo seeds demonstrated the highest ACE inhibitory activity. Molecular docking analysis indicated that resveratrol dimers, gnetin C and gnemonoside A can be considered ACE inhibitor.

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Section: Ace Inhibition Test and Ic 50 Measurement Testsupporting

confidence: 93%

Section: Ace Inhibition Test and Ic 50 Measurement Testmentioning

confidence: 91%

Section: Molecular Dockingmentioning

confidence: 92%

“…Su et al 2015 studied ACE inhibitory activity of stilbene from Ampelopsis brevipedunculata var. hancei [25].…”

Section: Ace Inhibition Test and Ic 50 Measurement Testmentioning

confidence: 99%

See 2 more Smart Citations

Angiotensin Converting Enzyme Inhibitory Activity of Melinjo (Gnetum Gnemon L.) Seed Extracts and Molecular Docking of Its Stilbene Constituents

Mun’im

Munadhil²,

Puspitasari³

et al. 2017

Asian J Pharm Clin Res

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“…Compared with the Res, the Oxy‐Res (5 μM) indicated stronger scavenging ability and higher tissue permeability . In recent years, the potential uses of the Oxy‐Res in noncommunicable diseases such as diabetes mellitus, Parkinson's disease, and cardiovascular illnesses have been explored . However, the antitumor effect of Oxy‐Res has seldom been reported .…”

Section: Introductionmentioning

confidence: 99%

Toxic trans‐crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer

Sun

Chen

et al. 2019

IUBMB Life

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The aim of this study was to explore how the toxic trans‐crotonaldehyde (TCA) in mitochondria or aldehyde dehydrogenase (ALDH) at different pHs was intercepted by oxyresveratrol (Oxy‐Res) contributing to anticancer. Ultraviolet–visible (UV–vis) spectroscopy and Raman spectroscopy were employed. UV–vis spectra showed that the Oxy‐Res red shifted the peak of the toxic TCA from 316 nm to 325 nm, while the peaks of the Oxy‐Res shifted from 329 nm with 290 nm and 300 nm to 325 nm with 303 nm. In the mitochondria, the Oxy‐Res blue shifted the peaks of the toxic TCA from 325 nm with 303 nm to 321 nm with 301 nm. Raman spectra revealed that the Oxy‐Res caused shifting of the CHO of the toxic TCA from 1,689 cm−1 to 1,671 cm−1 with band decline. The CC of the toxic TCA at 1641 cm−1 was split into 1,639 cm−1 and 1,642 cm−1 with band decline. The bands of the Oxy‐Res at 1634 cm−1, 1,617 cm−1, and 1,595 cm−1 disappeared. In the mitochondria, the CC of the toxic TCA at 1641 cm−1 splitting disappeared. In ALDH, with the decrease of pH from 7.8 to 6.5, the CHO of the toxic TCA did not red shift from 1,689 cm−1 to 1,674 cm−1 up to pH 6.5. There was no change in the CC of the toxic TCA at 1640 cm−1 in ALDH at different pHs. The conclusion of the study was that the CHO of the toxic TCA was intercepted by the Oxy‐Res under the action of ALDH in the mitochondria, particularly at pH 7.8. © 2019 IUBMB Life, 2019

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In the shadow of resveratrol: biological activities of epsilon-viniferin

et al. 2022

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Screening and profiling stilbene-type natural products with angiotensin-converting enzyme inhibitory activity from Ampelopsis brevipedunculata var. hancei (Planch.) Rehder

Cited by 17 publications

References 25 publications

Angiotensin Converting Enzyme Inhibitory Activity of Melinjo (Gnetum Gnemon L.) Seed Extracts and Molecular Docking of Its Stilbene Constituents

Angiotensin Converting Enzyme Inhibitory Activity of Melinjo (Gnetum Gnemon L.) Seed Extracts and Molecular Docking of Its Stilbene Constituents

Toxic trans‐crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer

In the shadow of resveratrol: biological activities of epsilon-viniferin

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