Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics
Nagarjunachary Ragi,
Scott J. Walmsley,
Foster C. Jacobs
et al.
Abstract:Air pollution, tobacco smoke, and red meat are associated with renal cell cancer (RCC) risk in the United States and Western Europe; however, the chemicals that form DNA adducts and initiate RCC are mainly unknown. Aristolochia herbaceous plants are used for medicinal purposes in Asia and worldwide. They are a significant risk factor for upper tract urothelial carcinoma (UTUC) and RCC to a lesser extent. The aristolochic acid (AA) 8-methoxy-6-nitrophenanthro-[3,4-d]-1,3dioxolo-5-carboxylic acid (AA-I), a compo… Show more
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