Screening endoscopy finds high prevalence of <i>Helicobacter pylori</i> and intestinal metaplasia in Korean American with limited access to health care

Woo, Yanghee; Behrendt, Carolyn E.; Trapp, Garrick; Hyun, Jae Chun; Gonda, Tamas A.; Fong, Yuman; Wang, Yichen

doi:10.1002/jso.24622

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Helicobacter pylori is the main risk factor for GIM development as GIM develops in the setting of inflammation and atrophy of gastric mucosa associated with H. pylori infection. 6,11 Other possible risk factors among U.S. populations include male gender, 12,13 non-white race/ethnicity, 12,14,15 older age, 14,16 and smoking. 17,18 A predictive model that combines demographic and clinical risk factors may identify individuals in the general population at high risk of GIM.…”

Section: Introductionmentioning

confidence: 99%

Risk Score Using Demographic and Clinical Risk Factors Predicts Gastric Intestinal Metaplasia Risk in a U.S. Population

Tan

Nguyen

et al. 2021

Dig Dis Sci

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Background/Aims Screening for gastric intestinal metaplasia (GIM) may lead to early gastric cancer detection. We developed and validated a pre-endoscopy risk prediction model for detection of GIM based on patient-level risk factors in a U.S. population. Methods We used data from 423 GIM cases and 1796 controls from a cross-sectional study among primary care and endoscopy clinic patients at the Houston VA. We developed the model using backwards stepwise regression and assessed discrimination using area under the receiver operating characteristic (AUROC). The model was internally validated using cross-validation and bootstrapping. The final expanded model was compared to a model including H. pylori infection alone and a baseline model including remaining terms without H. pylori. Results Male sex, older age, non-white race/ethnicity, smoking status, and H. pylori were associated with GIM risk. The expanded model including these terms had AUROC 0.73 (95%CI 0.71-0.76) for predicting GIM and AUROC 0.82 (95%CI 0.79-0.86) for extensive GIM. This model discriminated better than a model including only H. pylori (AUROC 0.66; 95%CI 0.63-0.68) and the baseline model (AUROC 0.67; 95%CI 0.64-0.70). The expanded model performed similarly among primary care (AUROC 0.75) and endoscopy (AUROC 0.73) patients. The expanded model showed sufficient internal validity (cross-validation AUROC 0.72) with little evidence of over-fitting. Conclusions We develop and validate a non-invasive risk model for GIM detection in a U.S. population that included terms for sex, age, race/ethnicity, smoking status, and H. pylori infection. Validated risk models would identify individuals with GIM who should be referred for endoscopic screening.

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Section: Introductionmentioning

confidence: 99%

Risk Score Using Demographic and Clinical Risk Factors Predicts Gastric Intestinal Metaplasia Risk in a U.S. Population

Tan

Nguyen

et al. 2021

Dig Dis Sci

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Blue laser imaging with acetic acid enhancement improved the detection rate of gastric intestinal metaplasia

Chen

Liu

et al. 2018

Lasers Med Sci

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Our aim was to evaluate the ability of blue laser imaging (BLI) combined with acetic acid (BLI-AA) to detect gastric intestinal metaplasia (GIM). Participants undergoing gastroscopy from July 2017 to February 2018 in our hospital were enrolled prospectively. The abilities of white light imaging endoscopy, BLI endoscopy, and BLI-AA to detect GIM were compared. One hundred six patients undergoing gastroscopy met the inclusion criteria. GIM was diagnosed in 41 patients. For BLI-AA, the sensitivity, specificity, positive predictive, and negative predictive values were 85.4%, 84.6%, 77.8%, and 90.2% respectively. The diagnostic accuracy rate for BLI-AA was 84.9%, which was higher than that of white light imaging endoscopy and BLI endoscopy. For target biopsy, the GIM detection rate for the BLI-AA mode was significantly higher (77.8%, 105/135) than that for the BLI mode (58.3%, 84/144) or the white light endoscopy mode (40.4%, 57/141) (p < 0.05). BLI-AA is an efficient and simple method for the detection of GIM.

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Endoscopy for Gastric Cancer Screening Is Cost Effective for Asian Americans in the United States

Shah

Canakis

Peek

et al. 2020

Clinical Gastroenterology and Hepatology

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Screening endoscopy finds high prevalence of Helicobacter pylori and intestinal metaplasia in Korean American with limited access to health care

Cited by 4 publications

References 31 publications

Risk Score Using Demographic and Clinical Risk Factors Predicts Gastric Intestinal Metaplasia Risk in a U.S. Population

Risk Score Using Demographic and Clinical Risk Factors Predicts Gastric Intestinal Metaplasia Risk in a U.S. Population

Blue laser imaging with acetic acid enhancement improved the detection rate of gastric intestinal metaplasia

Endoscopy for Gastric Cancer Screening Is Cost Effective for Asian Americans in the United States

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