Screening for Anti‐Aβ Aggregation Activity of Marine Fungal Natural Products Based on a Gold Nanoparticle Method
Xingyuan Wang,
Longjian Zhou,
Yayue Liu
et al.
Abstract:Screening Aβ aggregation inhibitors (AAIs) is important for Alzheimer's disease drug discovery. However, common cellular or biochemical methods are not suitable for high‐throughput natural product screening. A gold nanoparticle (GNP) screening method was employed in this study to screen marine fungal crude extracts and pure compounds for quick AAIs discovering. The anti‐Aβ aggregation activity was further inspected using transmission electron microscopic (TEM) observation and the interaction between active mol… Show more
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