Screening for celiac disease in Tunisian patients with Graves’ disease using anti-endomysium and anti-tissue transglutaminase antibodies

Mankaï, Amani; Chadli-Chaieb, M.; Saad, F.; Ghedira-Besbes, Leila; Ouertani, Mohamed Zied; Limem, M.; Abdessalem, M. Ben; Jeddi, M.; Chaieb, L.; Ghedira, Ibtissem

doi:10.1016/s0399-8320(06)73357-7

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…Out of 56 studies included in the systematic review, 25 were case‐control studies, 24‐47 17 were cohort studies 48‐64 and 14 were cross‐sectional studies 65‐78 . No clinical trials met the criteria used in the systematic review.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

Botello

Herrán

Salcedo

et al. 2020

Clinical Endocrinology

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Background Thyroid autoimmunity is the most frequent condition involved in polyautoimmunity (PolyA). However, the frequency of latent and overt PolyA in patients with autoimmune thyroid disease (AITD) as the index condition is unknown. Therefore, the purpose of this study was to determine the prevalence of these types of PolyA in patients with AITD as the index condition. Methods This study adhered to the relevant sections of the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guideline. Searches through MEDLINE, Embase and LILACS were done to find articles in Spanish and English. Relevant vocabulary terms and key terms related to AITD and other autoimmune diseases were used. Two investigators independently screened the eligible studies, extracted data and assessed the quality and risk of bias. Fixed and random effect models were used accordingly. Cluster analysis was used to determine similarities among diseases in the articles included (based on Jaccard index). Results A total of 56 articles fulfilled the inclusion criteria. Of these, 25 were case‐controls, 17 were cohorts, and 14 were cross‐sectional studies. These studies included a total of 47 509 patients. Female was the predominant gender and included 38 950 patients (81.23%, 95% CI: 80.85‐81.60). Graves’ disease (GD) was the most common type of thyroid autoimmunity (69.16%, 95% CI: 68.23‐70.07). Globally, overt PolyA was found in 13.46% of the patients with AITD. This type of PolyA was represented mainly by type 1 diabetes and autoimmune gastritis. Latent PolyA was presented in 17.45% of the patients, and anti‐proinsulin, anti‐parietal cells and dsDNA antibodies were the most common. HT had the highest frequency of overt PolyA in Europe (15.60%, 95% CI: 14.72‐16.53), whereas latent PolyA was most common in patients with GD in Asia (21.03%, 95% CI: 17.76‐24.71). Overt and latent PolyA were associated with gastrointestinal and endocrinological ADs in most of cases and clustered with rheumatological, dermatological and neurological ADs. Conclusions Latent and overt PolyA are common in patients with AITD. These results provide insightful information for early diagnosis and management of concurrent ADs in patients with AITD. Aggregation of ADs in different clusters may help to define different phenotypes associated with thyroid autoimmunity that are critically relevant in clinical settings.

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Section: Resultsmentioning

confidence: 99%

Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

Botello

Herrán

Salcedo

et al. 2020

Clinical Endocrinology

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“…Type of ATD. The prevalence of CD was slightly higher in hyperthyroidism (2.6% [CI 0.7-4.4]) (11,39,42) (8,23,25,26,28,30,31,33,39,43). The highest pooled prevalence was, however, seen in one study where the age of participants was unclear (9.0% [CI 5.3-12.8%]) (32).…”

Section: Prevalence Of CD In Atd Patientsmentioning

confidence: 99%

“…Biopsy data and Marsh III. Fifteen studies required Marsh III for the CD diagnosis (11,21,23,(25)(26)(27)(28)(29)(30)33,36,38,39,41,42). The prevalence of CD in these studies was 1.4% [CI 1.0-1.8%].…”

Section: Prevalence Of CD In Atd Patientsmentioning

confidence: 99%

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Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Roy

Laszkowska

Sundström

et al. 2016

Thyroid

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“…All six of them were also positive for anti-tTG. The prevalence of biopsy-confirmed CD in this population was 1.86% (3/161) [35].…”

Section: Clinical Prevalence Of Celiac Disease In Autoimmune Thyroid ...mentioning

confidence: 72%

Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod

Ashok¹,

Patni²,

Fatima³

et al. 2022

Cureus

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Celiac disease (CD) is a small intestinal inflammatory disease commonly seen in the Western population. It has been observed that patients with monoglandular and polyglandular autoimmunity have a higher prevalence of celiac disease. Hashimoto's thyroiditis (HT) and Graves' disease (GD), which mainly constitute the autoimmune thyroid diseases (AITD), characterized by lymphocytic infiltration of the thyroid parenchyma, are noted to be frequently associated with celiac disease. The fundamental mechanism of this frequent coexistence is thought to be a shared genetic background. Due to the subclinical nature of the celiac disease, the diagnosis is often missed or made coincidentally during screening. The rising prevalence of the celiac disease among AITD patients has urged researchers to investigate the link between the two. We reviewed the most recent and relevant literature on the intriguing relationship between celiac disease and thyroid autoimmunity. The objectives of this article were to study the shared genetic background, the incidence of CD in AITD, the effect of a gluten-free diet on AITD, and the need for routine screening of CD in AITD patients.

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Screening for celiac disease in Tunisian patients with Graves’ disease using anti-endomysium and anti-tissue transglutaminase antibodies

Cited by 13 publications

References 28 publications

Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod

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