Screening for Chlamydia trachomatis in asymptomatic women attending outpatient clinics in a large maternity hospital in Dublin, Ireland

McMillan, Hugh J.; O'Carroll, H; Lambert, John S.; Grundy, KB; O'Reilly, Marion; Lennon, Bernadette; C, Collins; Walsh, Tim; Geary, Meghan; Mt, Cafferkey

doi:10.1136/sti.2006.020990

Cited by 14 publications

(14 citation statements)

References 13 publications

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“…Recently a study was conducted to determine the prevalence of C. trachomatis in women attending a maternity hospital for antenatal, fertility and family planning services. A prevalence of C. trachomatis of 3.7% was found in urine samples 26 . Testing of urine samples using nucleic acid‐based techniques has often been criticized due to the presence of amplification inhibitors in urine 27–29 .…”

Section: Discussionmentioning

confidence: 99%

“…A prevalence of C. trachomatis of 3.7% was found in urine samples. 26 Testing of urine samples using nucleic acid-based techniques has often been criticized due to the presence of amplification inhibitors in urine. [27][28][29] In our study, DNA was extracted from residual cells in PreservCyt medium following routine cervical smear testing from which all samples amplified for the internal control and no amplification inhibition was observed.…”

Section: Discussionmentioning

confidence: 99%

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Chlamydia trachomatis detection in cervical PreservCyt specimens from an Irish urban female population

Keegan

Ryan²,

Malkin³

et al. 2009

Cytopathology

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Objective: The aim of this study was to determine the prevalence of cervical Chlamydia trachomatis infection by polymerase chain reaction (PCR) in urban women undergoing routine cervical cytological screening and to investigate the relationship with age, cytology, smoking status and concurrent human papillomavirus (HPV) infection. Methods: A total of 996 women (age range 16–69 years) attending general practitioners for routine liquid‐based cervical smear screening in the Dublin area were recruited in the study of prevalence of C. trachomatis. Informed consent was obtained and liquid‐based cytology (LBC) specimens were sent for cytological screening. DNA was extracted from residual LBC and tested for C. trachomatis by PCR using the highly sensitive C. trachomatis plasmid (CTP) primers and for HPV infection using the MY09/11 primers directed to the HPV L1 gene in a multiplex format. Results: The overall prevalence of C. trachomatis was 5.4%. Prevalence was highest in the <25 years age group (10%). Coinfection with HPV and C. trachomatis occurred in 1% of the screening population. A higher rate of smoking was observed in women positive for C. trachomatis, HPV infections or those with abnormal cervical cytology. Chlamydia trachomatis infection was not associated with abnormal cytology. Conclusions: Women (5.4%) presenting for routine cervical screening are infected with C. trachomatis. Opportunistic screening for C. trachomatis from PreservCyt sample taken at the time of cervical cytological screening may be a possible strategy to screen for C. trachomatis in the Irish female population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis detection in cervical PreservCyt specimens from an Irish urban female population

Keegan

Ryan²,

Malkin³

et al. 2009

Cytopathology

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“…Questions were based on previous studies and the literature [8,19,22-24]. Questionnaires were provided with a prepaid return envelope.…”

Section: Methodsmentioning

confidence: 99%

Knowledge and acceptability of Chlamydia trachomatis screening among pregnant women and their partners; a cross-sectional study

et al. 2014

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BackgroundChlamydia trachomatis infections in pregnancy can cause maternal disease, adverse pregnancy outcomes and neonatal disease, which is why chlamydia screening during pregnancy has been advocated. The effectiveness of a screening program depends on the knowledge of health care professionals, women and partners and the acceptability for screening of the target population. We assessed the knowledge of chlamydia infection among pregnant women and their partners in the Netherlands, their attitudes towards testing, and their experiences of being offered a chlamydia test. In addition, we evaluated the association between participants’ background characteristics and knowledge of chlamydia.MethodsPregnant women aged ≤ 30 years and their partners (regardless of their age) attending one of the participating primary midwifery care practices in the Netherlands were invited to participate. All participants completed a questionnaire, pregnant women provided a vaginal swab and partners provided a urine sample to test for C. trachomatis.ResultsIn total, 383 pregnant women and 282 partners participated in the study of whom 1.9% women and 2.6% partners tested chlamydia positive. Participants had high levels of awareness (92.8%) of chlamydial infection. They were knowledgeable about the risk of chlamydia infection; median knowledge score was 9.0 out of 12.0. Lower knowledge scores were found among partners (p-value <0.001), younger aged (p-value 0.02), non-western origin (p-value <0.001), low educational level (p-value <0.001), and no history of sexually transmitted infections (p-value <0.001). In total, 78% of respondents indicated that when pregnant women are tested for chlamydia, their partners should also be tested; 54% believed that all women should routinely be tested. Pregnant women more often indicated than partners that testing partners for chlamydial infection was not necessary (p-value <0.001). The majority of pregnant women (56.2%) and partners (59.2%) felt satisfied by being offered the test during antenatal care.ConclusionPregnant women and their partners were knowledgeable about chlamydial infection, found testing, both pregnant women and their partners, for chlamydia acceptable and not stigmatizing.

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“…145,146 In our own practice, in a population where universal opportunistic screening was not postulated to be cost-effective, 147 routine prenatal screening for Chlamydia trachomatis reveals a prevalence of 3.7% (in a study that excluded symptomatic patients). 148 This compares to an estimated overall prevalence of chlamydia in 1.6% of all females in the United Kingdom and Ireland, but in 8.5% of females attending prenatal clinics or termination of pregnancy clinics in these same jurisdictions. 145 A prospective study of pregnant adolescents in Washington, DC, detected either chlamydia or gonorrhea in 31% of eligible patients at some point during their pregnancy.…”

Section: Chlamydia Trachomatis and Neisseria Gonorrhoeaementioning

confidence: 97%

Clinical Focus: Infections in Pregnancy

Adler

Lambert

2014

Hospital Practice

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Pregnant women are particularly susceptible to a number of infectious diseases, such as influenza, hepatitis E, malaria, and tuberculosis. The management of many other infections-including urinary tract infections, human immunodeficiency virus, and sexually transmitted diseases-is also made more complex by pregnancy; even if some infections do not pose a great risk to the expectant mother, they can impact fetal and neonatal development, thus posing a treatment challenge to physicians. By focusing on the most important diseases that physicians may encounter in pregnant patients, this review outlines the challenges associated with managing important infectious diseases in the pregnant population and references the most recent evidence and international treatment guidelines.

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Screening for Chlamydia trachomatis in asymptomatic women attending outpatient clinics in a large maternity hospital in Dublin, Ireland

Cited by 14 publications

References 13 publications

Chlamydia trachomatis detection in cervical PreservCyt specimens from an Irish urban female population

Chlamydia trachomatis detection in cervical PreservCyt specimens from an Irish urban female population

Knowledge and acceptability of Chlamydia trachomatis screening among pregnant women and their partners; a cross-sectional study

Clinical Focus: Infections in Pregnancy

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