Screening for gestational diabetes mellitus: a Caribbean perspective

Bassaw, B; Fletcher, Horace; Rattray, Carole; McIntyre, G; Sarkharkar, Vrunda; Sankat, Sarisha; Sirjusingh, A; Chinnia, Javed

doi:10.1080/01443615.2018.1467389

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…The resultant causes defects in insulin action and insulin secretion. Hyperglycemia during pregnancy is attributed to long-term dysfunction and affects the motherʼs and offspringʼs vital organs as well as raising the risk of fetal-maternal morbidity [4][5][6] . Moreover, the offspring of women who suffered from GDM have more chances to expand their diminished glucose tolerance, obesity and metabolic dysfunction in later life 2,7,8 .…”

Section: Introductionmentioning

confidence: 99%

Alpha Mangostin Ameliorates Gestational Diabetes in Rats via Alteration of Oxidative Stress and Inflammation Reaction

He¹,

Ye²,

Li³

et al. 2023

International J. of Pharmacology

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Background and Objective: Diabetes mellitus and impaired glucose tolerance discovered during pregnancy without a previous history of the disease are referred to as Gestational Diabetes Mellitus (GDM). GDM is known to have a high chance of causing type 2 diabetes. GDM is becoming more common around the world and it has a significant impact on patientʼs quality of life and raises the risk of pregnancy. The current study scrutinized the protective effect of alpha mangostin against streptozotocin (STZ) induced Gestational Diabetes Mellitus (GDM) in rats. Materials and Methods: Wistar rats were used in this experimental study. The STZ was used for the induction of GDM. The rats received the oral administration of alpha mangostin (5, 10 and 15 mg kgG 1 ). Blood glucose level, fetal weight, body weight, placental weight and plasma insulin were estimated. Intraperitoneal Insulin Tolerance Test ( IpITT) and Oral Glucose Tolerance Test (OGTT) were determined. The mRNA expression of SREBP-1 and its targeted genes. Results: Alpha mangostin significantly (p<0.001) improved the plasma insulin level and body weight and reduced blood glucose level. Alpha mangostin significantly (p<0.001) improved the insulin level in IPTT and reduced the blood glucose level in the OGTT test. Alpha mangostin treatment considerably improved fetal weight and suppressed placental weight. Alpha mangostin significantly (p<0.001) altered the lipid, antioxidant and inflammatory cytokines. Alpha mangostin significantly (p<0.001) suppressed the mRNA expression of SCD-1, SREBP-1, FAS and ACC. Conclusion: Taken together, alpha mangostin can be considered an alternative treatment for gestational diabetes.

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Section: Introductionmentioning

confidence: 99%

Alpha Mangostin Ameliorates Gestational Diabetes in Rats via Alteration of Oxidative Stress and Inflammation Reaction

He¹,

Ye²,

Li³

et al. 2023

International J. of Pharmacology

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“…The increasing prevalence of diabetes in the general population and getting pregnant in older ages has caused an increased number of diabetic pregnancies. [1][2][3] Gestational diabetes mellitus (GDM) affects 3%-6% of all pregnancies. [4][5][6] There is an increased risk of maternal and fetal complications associated with both overt and gestational diabetes.…”

Section: Introductionmentioning

confidence: 99%

Does routine antenatal fetal testing in well-controlled diabetic pregnancies improve pregnancy outcomes? A systematic review and meta-analysis

et al. 2021

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Background: Various fetal surveillance tests are proposed to reduce the rate of stillbirth in diabetic mothers, however there is no sufficient evidence to support this. Objective: The purpose of the present systematic review was to assess the effects of fetal testing on reducing fetal mortality in pregnancies with diabetes. Materials and Methods: The databases were searched to find English and Persian articles published from 1975-2018 about antenatal fetal assessment in pregnancies complicated with diabetes. Relevant sources cited in the selected publications were also searched manually. Keywords were GDM, pregnancy, fetal testing, fetal surveillance, NST, BPP, CTG. A total of 1954 studies were identified. Of these, 1913 were excluded on the basis of title and abstract review. Results: Among the 41 studies retrieved for detailed full-text analysis, a total of 10 fulfilled the inclusion criteria for the analysis. Still birth rate was 5.6/1000, cesarean rate was 418/1000. In diabetic pregnant women (gestational and overt diabetes) with well controlled blood sugar who did fetal surveillance tests the intrauterine fetal death rate isn’t different with general population. Conclusion: As this systematic review suggests, fetal mortality is rare with fetal surveillance tests in pregnant diabetic women with good blood sugar control. No randomized clinical trial has been conducted to investigate this claim.

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Screening for gestational diabetes mellitus: a Caribbean perspective

Cited by 2 publications

References 18 publications

Alpha Mangostin Ameliorates Gestational Diabetes in Rats via Alteration of Oxidative Stress and Inflammation Reaction

Alpha Mangostin Ameliorates Gestational Diabetes in Rats via Alteration of Oxidative Stress and Inflammation Reaction

Does routine antenatal fetal testing in well-controlled diabetic pregnancies improve pregnancy outcomes? A systematic review and meta-analysis

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