Screening for HbA1c-defined prediabetes and diabetes in an at-risk greek population: Performance comparison of random capillary glucose, the ADA diabetes risk test and skin fluorescence spectroscopy

Tentolouris, Nicholas; Lathouris, Panagiotis; Lontou, Stavroula P.; Tzemos, Kostas; Maynard, John

doi:10.1016/j.diabres.2013.01.002

Cited by 17 publications

(12 citation statements)

References 29 publications

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“…Confirmatory values could come from a variety of sources depending on the nature of the intervention, including physician referrals, participant medical records, and worksite, community or practice-based screenings. Further study is needed to determine the most efficient, cost effective method to identify individuals who have prediabetes or meet additional program specific eligibility criteria like the metabolic syndrome and may include recent advances in technology such as skin fluorescence spectroscopy[44]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of non-invasive screening measures to identify individuals with prediabetes

Vanderwood

Kramer

Miller

et al. 2015

Diabetes Research and Clinical Practice

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Aims Because blood-based screening to identify those with prediabetes to take part in Diabetes Prevention Program (DPP) translation efforts can be costly and time-consuming, non-invasive methods are needed. The aims of this paper are to evaluate the ability of the American Diabetes Association (ADA) risk test in identifying individuals with prediabetes, as well as the use of body composition measures for this purpose. In addition the utility of these alternate methods to ascertain the presence of the metabolic syndrome was assessed. Methods Potential participants were recruited from a worksite and three community centers to take part in a DPP translation study. Participants completed onsite screening where anthropometric measures, fasting lipids and glucose, and hemoglobin A1c were assessed. Those with a BMI ≥24kg/m2 and prediabetes and/or the metabolic syndrome were eligible to participate. Non-invasive screening methods were evaluated for their ability to identify those with prediabetes and the metabolic syndrome based on clinically measured values. Results All non-invasive methods were highly sensitive (68.9% to 98.5%) in the detection of prediabetes, but specificity was low (6.7% to 44.5%). None of the alternatives evaluated achieved acceptable discrimination levels in ROC analysis. Similar results were noted in identifying the metabolic syndrome. Conclusions The non-invasive methods evaluated in this study effectively identify participants with prediabetes, but would also allow for enrollment of a large number of individuals who do not have prediabetes. Deciding whether to use these alternatives, blood-based measures, or a combination of both will ultimately depend on the purpose of the program and the level of flexibility regarding participant eligibility.

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Section: Discussionmentioning

confidence: 99%

Evaluation of non-invasive screening measures to identify individuals with prediabetes

Vanderwood

Kramer

Miller

et al. 2015

Diabetes Research and Clinical Practice

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“…Cut-off values for SAF would be ≥80th (< 50 years) or ≥70th (≥ 50 years) age percentile, based on previously published reference values [ 21 ], for which patients should be referred for oral glucose tolerance tests. For the SCOUT device, a few studies have shown that SIF had a similar or superior performance to fasting plasma glucose, HbA1c, and/or capillary glucose in detecting abnormal glucose tolerance [ 29 , 34 , 35 ].…”

Section: Skin Fluorescence In Diabetes Screeningmentioning

confidence: 99%

Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

Fokkens

Smit

2016

Glycoconj J

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Glycation is important in the development of complications of diabetes mellitus and may have a central role in the well-described glycaemic memory effect in developing these complications. Skin fluorescence has emerged over the last decade as a non-invasive method for assessing accumulation of advanced glycation endproducts. Skin fluorescence is independently related to micro- and macrovascular complications in both type 1 and type 2 diabetes mellitus and is associated with mortality in type 2 diabetes. The relation between skin fluorescence and cardiovascular disease also extends to other conditions with increased tissue AGE levels, such as renal failure. Besides cardiovascular complications, skin fluorescence has been associated, more recently, with other prevalent conditions in diabetes, such as brain atrophy and depression. Furthermore, skin fluorescence is related to past long-term glycaemic control and clinical markers of cardiovascular disease. This review will discuss the technique of skin fluorescence, its validation as a marker of tissue AGE accumulation, and its use as a clinical tool for the prediction of long-term complications in diabetes mellitus.

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“…Further data by Tentolouris and coauthors 20 in a group of 398 persons at risk for developing T2DM add to this evidence. Dysglycemia [≥5.7% (39 mmol/mol)] or diabetes [≥6.5% (47.5 mmol/mol)] were diagnosed using HbA1c measurements.…”

mentioning

confidence: 91%

“…[19][20][21][22] Moreover, SFS measurements provide additional information to the UK Prospective Diabetes Study risk score in people with T2DM, 28 correlate with the severity of peripheral and autonomic diabetic neuropathy, 29 and can be used for the identification of subjects with T2DM and an increased risk for developing microvascular 30 and macrovascular complications. 31 Therefore, the measurement of SFS seems to be of interest for the diagnosis of diabetes, the assessment of cardiovascular risk, as well as the risk for developing diabetes complications.…”

mentioning

confidence: 99%

Noninvasive Skin Fluorescence Spectroscopy for Diabetes Screening

Stirban

2013

J Diabetes Sci Technol

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Abbreviations: (AGE) advanced glycation end product, (CV) coefficient of variation, (FPG) fasting plasma glucose, (HbA1c) glycated hemoglobin A1c, (IGT) impaired glucose tolerance, (OGTT) oral glucose tolerance test, (SFS) skin fluorescence spectroscopy, (T2DM) type 2 diabetes mellitus AbstractThe development of cost-effective, simple, and reproducible tests for diabetes screening represents a priority of modern medicine in light of the increasing prevalence of diabetes mellitus. Besides fasting plasma glucose, the oral glucose tolerance test, and glycated hemoglobin A1c, several tests have been proposed, among them the assessment of skin fluorescence spectroscopy (SFS). This article comments on the article by Olson and coauthors published in this issue of Journal of Diabetes Science and Technology and comprehensively reviews related available information. Overall, SFS seems to represent an easy-to-use, noninvasive tool that adds value to existing tests for diabetes screening.

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Screening for HbA1c-defined prediabetes and diabetes in an at-risk greek population: Performance comparison of random capillary glucose, the ADA diabetes risk test and skin fluorescence spectroscopy

Cited by 17 publications

References 29 publications

Evaluation of non-invasive screening measures to identify individuals with prediabetes

Evaluation of non-invasive screening measures to identify individuals with prediabetes

Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

Noninvasive Skin Fluorescence Spectroscopy for Diabetes Screening

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