Screening for metabolic syndrome application of a herring by-product hydrolysate after its separation by electrodialysis with ultrafiltration membrane and identification of novel anti-inflammatory peptides

Durand, Rachel; Pellerin, Geneviève; Thibodeau, Jacinthe; Fraboulet, Erwann; Marette, André; Bazinet, Laurent

doi:10.1016/j.seppur.2019.116205

Cited by 44 publications

(47 citation statements)

References 42 publications

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“…These differences in composition may explain the higher efficiencies of HMH2 and HMH3 treatments. Indeed, in a previous study, the separation of HMH1 by electrodialysis with an ultrafiltration membrane (EDUF) led to the identification of two new anti-inflammatory peptides: IVPAS and FDKPVSPLL [22]. However, in the present study, HMH1 was reported to have no anti-inflammatory effect.…”

Section: Discussioncontrasting

confidence: 59%

“…HMH2 and HMH3 are the herring milt hydrolysate retentate after their separation by an ultrafiltration membrane, while HMH1 is the permeate. Hence, HMH1 is mostly composed of small-weight peptides and free amino acids, while HMH2 and HMH3 are composed of higher-weight peptides and lipids [22,43]. These differences in composition may explain the higher efficiencies of HMH2 and HMH3 treatments.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding herring processing, the milt could represent a promising co-product rich in proteins and lipids. Indeed, we previously identified two anti-inflammatory peptides from a herring milt hydrolysate obtained from separation by electrodialysis with an ultrafiltration membrane [22]. Moreover, Wang et al observed an improvement of insulin resistance in obese mice fed a high-fat diet in which a large proportion of the protein source (70%) was from herring milt hydrolysate [23].…”

Section: Introductionmentioning

confidence: 99%

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Animal and Cellular Studies Demonstrate Some of the Beneficial Impacts of Herring Milt Hydrolysates on Obesity-Induced Glucose Intolerance and Inflammation

et al. 2020

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The search for bioactive compounds from enzymatic hydrolysates has increased in the last few decades. Fish by-products have been shown to be rich in these valuable molecules; for instance, herring milt is a complex matrix composed of lipids, nucleotides, minerals, and proteins. However, limited information is available on the potential health benefits of this by-product. In this context, three industrial products containing herring milt hydrolysate (HMH) were tested in both animal and cellular models to measure their effects on obesity-related metabolic disorders. Male C57Bl/6J mice were fed either a control chow diet or a high-fat high-sucrose (HFHS) diet for 8 weeks and received either the vehicle (water) or one of the three HMH products (HMH1, HMH2, and HMH3) at a dose of 208.8 mg/kg (representing 1 g/day for a human) by daily oral gavage. The impact of HMH treatments on insulin and glucose tolerance, lipid homeostasis, liver gene expression, and the gut microbiota profile was studied. In parallel, the effects of HMH on glucose uptake and inflammation were studied in L6 myocytes and J774 macrophages, respectively. In vivo, daily treatment with HMH2 and HMH3 improved early time point glycemia during the oral glucose tolerance test (OGTT) induced by the HFHS diet, without changes in weight gain and insulin secretion. Interestingly, we also observed that HMH2 consumption partially prevented a lower abundance of Lactobacillus species in the gut microbiota of HFHS diet-fed animals. In addition to this, modulations of gene expression in the liver, such as the upregulation of sucrose nonfermenting AMPK-related kinase (SNARK), were reported for the first time in mice treated with HMH products. While HMH2 and HMH3 inhibited inducible nitric oxide synthase (iNOS) induction in J774 macrophages, glucose uptake was not modified in L6 muscle cells. These results indicate that milt herring hydrolysates reduce some metabolic and inflammatory alterations in cellular and animal models, suggesting a possible novel marine ingredient to help fight against obesity-related immunometabolic disorders.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Animal and Cellular Studies Demonstrate Some of the Beneficial Impacts of Herring Milt Hydrolysates on Obesity-Induced Glucose Intolerance and Inflammation

et al. 2020

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“…Recent EDUF advances include the stacking of UFMs with different MWCOs in order to improve size-selectivity as well as the in-situ enzymatic hydrolysis. Hence, the recovery of 4 fractions with two cationic compartments and two anionic compartments was investigated [ 238 , 239 ]. Furthermore, triple selectivity was obtained by stacking three UFMs of decreasing MWCOs [ 240 ].…”

Section: Recent Technological Developments Based On Ed Membrane Phmentioning

confidence: 99%

Electrodialytic Processes: Market Overview, Membrane Phenomena, Recent Developments and Sustainable Strategies

Bazinet

Geoffroy

2020

Membranes

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In the context of preserving and improving human health, electrodialytic processes are very promising perspectives. Indeed, they allow the treatment of water, preservation of food products, production of bioactive compounds, extraction of organic acids, and recovery of energy from natural and wastewaters without major environmental impact. Hence, the aim of the present review is to give a global portrait of the most recent developments in electrodialytic membrane phenomena and their uses in sustainable strategies. It has appeared that new knowledge on pulsed electric fields, electroconvective vortices, overlimiting conditions and reversal modes as well as recent demonstrations of their applications are currently boosting the interest for electrodialytic processes. However, the hurdles are still high when dealing with scale-ups and real-life conditions. Furthermore, looking at the recent research trends, potable water and wastewater treatment as well as the production of value-added bioactive products in a circular economy will probably be the main applications to be developed and improved. All these processes, taking into account their principles and specificities, can be used for specific eco-efficient applications. However, to prove the sustainability of such process strategies, more life cycle assessments will be necessary to convince people of the merits of coupling these technologies.

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“…The resulting hydrolysates have gained more and more attention from the food, nutraceutical and cosmetics sectors, since they could be of biological interest, having antioxidant, anticancer, antidiabetic, antihypertensive or antimicrobial activities [2][3][4][5][6][7]. Recently, the valorization of herring milt hydrolysate (HMH) has been much more considered, since it contains high value-added molecules, such as peptides, amino acids, nucleic acids and vitamins, and since it has already proven its relevance regarding metabolic syndrome illnesses [1,8]. However, in spite of these promising aspects, HMH, similarly to other fish hydrolysates, presents the substantial drawback of being associated with unpleasant smells [9].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Performance of Electrodialysis in the Removal of the Most Potent Odor-Active Compounds of Herring Milt Hydrolysate: Focus on Ion-Exchange Membrane Fouling and Water Dissociation as Limiting Process Conditions

et al. 2020

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Herring milt hydrolysate (HMH), like many fish products, presents the drawback to be associated with off-flavors. As odor is an important criterion, an effective deodorization method targeting the volatile compounds responsible for off-flavors needs to be developed. The potential of electrodialysis (ED) to remove the 15 volatile compounds identified, in the first part of this work, for their main contribution to the odor of HMH, as well as trimethylamine, dimethylamine and trimethylamine oxide, was assessed by testing the impact of both hydrolysate pH (4 and 7) and current conditions (no current vs. current applied). The ED performance was compared with that of a deaerator by assessing three hydrolysate pH values (4, 7 and 10). The initial pH of HMH had a huge impact on the targeted compounds, while ED had no effect. The fouling formation, resulting from electrostatic and hydrophobic interactions between HMH constituents and ion-exchange membranes (IEM); the occurrence of water dissociation on IEM interfaces, due to the reaching of the limiting current density; and the presence of water dissociation catalyzers were considered as the major limiting process conditions. The deaerator treatment on hydrolysate at pH 7 and its alkalization until pH 10 led to the best removal of odorant compounds.

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Screening for metabolic syndrome application of a herring by-product hydrolysate after its separation by electrodialysis with ultrafiltration membrane and identification of novel anti-inflammatory peptides

Cited by 44 publications

References 42 publications

Animal and Cellular Studies Demonstrate Some of the Beneficial Impacts of Herring Milt Hydrolysates on Obesity-Induced Glucose Intolerance and Inflammation

Animal and Cellular Studies Demonstrate Some of the Beneficial Impacts of Herring Milt Hydrolysates on Obesity-Induced Glucose Intolerance and Inflammation

Electrodialytic Processes: Market Overview, Membrane Phenomena, Recent Developments and Sustainable Strategies

Assessment of the Performance of Electrodialysis in the Removal of the Most Potent Odor-Active Compounds of Herring Milt Hydrolysate: Focus on Ion-Exchange Membrane Fouling and Water Dissociation as Limiting Process Conditions

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