Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz

Li, Cuiqin; He, Langchong; Dong, Hao; Jin, Ju-qing

doi:10.1016/j.jep.2007.08.002

Cited by 166 publications

(101 citation statements)

References 17 publications

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“…The Yiqigubiao formula, and a similar therapy termed Bu Qi Gu Biao therapy, have been used to treat allergic rhinitis (20,44). The anti-inflammatory functions of the Yiqigubiao pill arise from the active ingredients of the involved herbs, a number of which have been reported to be anti-inflammatory (45)(46)(47). We propose that Yiqigubiao pill may provide supplementary benefits to the conventional therapy used in the treatment of patients with COPD in relieving inflammatory responses.…”

Section: Prior To Intervention a After Interventionmentioning

confidence: 98%

Randomized, double-blind, placebo-controlled superiority trial of the Yiqigubiao pill for the treatment of patients with chronic obstructive pulmonary disease at a stable stage

Zheng

et al. 2016

Experimental and Therapeutic Medicine

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Section: Prior To Intervention a After Interventionmentioning

confidence: 98%

Randomized, double-blind, placebo-controlled superiority trial of the Yiqigubiao pill for the treatment of patients with chronic obstructive pulmonary disease at a stable stage

Zheng

et al. 2016

Experimental and Therapeutic Medicine

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“…The vascular permeability test was determined colorimetrically following the method of Li et al (2007) with a minor modification. Briefly, 0.75% (v/v) acetic acid in normal saline (10 mL/kg) was injected into the abdominal cavity at 1 h after the final administration of the XYT and dexamethasone.…”

Section: Assay Of Acetic Acid-induced Vascular Permeability In Micementioning

confidence: 99%

“…The carrageenan-induced paw edema test was determined according to the method of Li et al (2007) with a minor modification. Briefly, 0.1 mL of 1% (w/v) carrageenan in distilled water was injected subcutaneously into the plantar surface of the right hind-paw at 30 min after the final administration of the XYT and dexamethasone.…”

Section: Assay Of Carrageenan-induced Paw Edema In Ratsmentioning

confidence: 99%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug.Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the antiinflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p50.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant antiinflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.

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“…Glycoproteins in the AMK sample were the most prominent ingredients responsible for splenocyte stimulation and cytokine secretion (Lee et al, 2007). The polysaccharide fractions of AMK have been reported to improve humoral immunity in pigs (Li et al, 2007). Low molecular weight substances, including sesquiterpenoids and triterpenoids, were identified from AMK as inhibitors of Na + -K + -ATPase and neuromuscular connections (Kimura et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Dietary supplementation with AMK polysaccharide improved the immune response by elevating the proliferation of Lactobacillus, mRNA expression and level of cytokines, and ameliorating the proliferation of lymphocytes and metabolic status in early-weaned pigs (Li et al, 2011). Atractylenolide I and acetylenic compound from AMK were found to be active compounds in different anti-inflammatory assays (Li et al, 2007). Glycoproteins from AMK markedly stimulated lymphocyte proliferation, antibody production, and cytokine secretion in mouse splenocytes (Lee et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The effects of supplementing diets with <i>Atractylodes macrocephala</i> Koidz rhizomes on growth performance and immune function in piglets

Xu¹,

Zhao²,

Shang³

et al. 2012

J. Anim. Feed Sci.

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The rhizome of Atractylodes macrocephala Koidz (baizhu in Chinese, AMK) is a well-known traditional Chinese medicine that has long been used as a digestive and tonic. The experiment was conducted to investigate the effect of baizhu powder on the growth performance and immune function of piglets. Duroc × Landrace×Yorkshire piglets (n=72, half males and half females, 42 days of age, liveweight 14.82±0.17 kg) were randomly allocated to three treatments: control, control+AMK either ground (GMD=180 μm), or micronized (GMD=5.59 μm), for 30 days. The results showed that supplementation with micronized baizhu significantly increased average daily gain (ADG) (P<0.05) and decreased (P<0.05) the feed/gain and diarrhoea ratios compared with the control group. Pigs given 80 mesh baizhu had a lower (P<0.05) diarrhoea ratio than those fed the control diet. Supplementation with 80 mesh baizhu and micronized baizhu significantly increased (P<0.05) both concanavalin-(ConA) and lipopolysaccharide (LPS)-induced splenocyte and peripheral lymphocyte proliferation, serum IgG, IL-1, and IL-2 concentrations (P<0.05) compared with the control group. In addition, supplementation with micronized baizhu significantly enhanced (P<0.05) PR-39 mRNA expression compared with the control group. The results indicate that baizhu could ameliorate metabolic status and regulate immune function to improve the growth performance of piglets, and that super-fine comminution may improve its medicinal efficiency.

show abstract

Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz

Cited by 166 publications

References 17 publications

Randomized, double-blind, placebo-controlled superiority trial of the Yiqigubiao pill for the treatment of patients with chronic obstructive pulmonary disease at a stable stage

Randomized, double-blind, placebo-controlled superiority trial of the Yiqigubiao pill for the treatment of patients with chronic obstructive pulmonary disease at a stable stage

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

The effects of supplementing diets with <i>Atractylodes macrocephala</i> Koidz rhizomes on growth performance and immune function in piglets

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