Screening for Tuberculosis Infection in Children and Adolescents in Russia – Past, Present, Future

Aksenova, Valentina; Барышникова, Л. А.; Klevno, N. I.; Kudlay, Dmitry

doi:10.21292/2075-1230-2019-97-9-59-67

Cited by 13 publications

(12 citation statements)

References 19 publications

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“…The incidence rate of TB in children aged 0-14 years decreased to 8.3 per 100 000 children in 2018 or by 49.4% from 2012 (Aksenova et al, 2019;Starshinova et al, 2019). Among adolescents, the incidence rate of TB in children aged 15-17 years also decreased to 18.1 per 100 000 children by 2018 and by 53.6% from 2006, when the maximum rate was recorded (39.0 per 100 000 children).…”

Section: Resultsmentioning

confidence: 93%

Latent tuberculosis infection in children and adolescents in Russia

Aksenova

Vasilyeva

Kasaeva

et al. 2020

International Journal of Infectious Diseases

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Background: After the breakup of the Soviet Union, the annual incidence of tuberculosis (TB) in children 15-17 years of age increased in the Russian Federation from 16 per 100 000 population in 1992 to 37 per 100 000 in 2009, and new control measures were implemented. Methods: Children were screened annually for TB exposure with a tuberculin skin test (TST) at age 1-8 years. If positive, they were investigated for active TB. If no active TB was found, they were treated with isoniazid for 4-6 months; they then underwent 6-monthly skin tests (which included two recombinant proteins) until negative and annual skin tests thereafter. From the age of 8 years, the yearly follow-up was performed using the skin test that included two recombinant proteins, either until they became negative, developed active TB, or turned 18 years. Results: The annual incidence of TB in Russian children decreased from 19.1 per 100 000 population in 2001 to 8.3 per 100 000 population in 2018. Conclusions: Annual screening for TB exposure with treatment for latent or active TB has reduced the annual incidence of TB in Russian children aged 15-17 years to 1992 levels.

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Section: Resultsmentioning

confidence: 93%

Latent tuberculosis infection in children and adolescents in Russia

Aksenova

Vasilyeva

Kasaeva

et al. 2020

International Journal of Infectious Diseases

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“…Additionally, new protocols have been developed for the treatment of drug-resistant tuberculosis with the use of bedaquiline [ 25 ], linezolid, and thioureidoiminomethylpyridinium perchlorate, all of which have been approved for use [ 26 , 27 ]. New methods of immunodiagnostics have been introduced (such as testing with a recombinant tuberculosis allergen (Diaskintest ® )), ELISPOT, QuantiFERON-TB Gold) [ 28 , 29 ], and computed tomography has been introduced into the diagnostic protocol.…”

Section: Discussionmentioning

confidence: 99%

“…This progress was also reflected in the reduction in TB incidence among children and adolescents; in 2020, according to the Federal Monitoring Center, this amounted to 6.2 and 12.7 cases per 100,000 people, respectively [ 14 , 29 , 32 , 33 ]. The results obtained might not objectively reflect the epidemiological situation, which may subsequently lead to the incidence rate increasing and the emergence of severe forms of tuberculosis in both the adult population and in children in the most disadvantaged regions.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis in the Russian Federation: Dynamics of the Epidemic Indicators before and after COVID-19 Pandemic

Старшинова

Dovgalyk

Beltukov

et al. 2022

Life

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The measures taken against tuberculosis (TB) in recent years in the Russian Federation have been highly effective. Unfortunately, the COVID-19 pandemic may seriously undermine the progress that has been made in the fight against TB. The aim of this study was to assess changes in the epidemiological rates of tuberculosis in the Russian Federation before and after the COVID-19 pandemic. Materials and methods. The analysis was conducted by considering the main epidemiological indicators of tuberculosis, according to the federal statistics for the period from 2017 to 2021. The parameters were estimated according to the data received from 11 areas in the North-Western region. Statistical analysis was carried out using the free software computing environment R (v.3.5.1) and the commercial software package Statistical Package for the Social Sciences (SPSS Statistics for Windows, version 24.0, IBM Corp., 2016). Research results. We found a positive correlation between the incidence among the overall population and the incidence among children aged 0–17, inclusively (r = 0.55 in 2017, r = 0.60 in 2020, and r = 0.53 in 2021). Along with the received regularities, a different trend is shown in the data analysis of general incidence and health X-ray examination for tuberculosis among the general population. The correlation has decreased threefold from 2017 (r = 0.72) to 2020 (r = 0.32); this negative trend might be the result of factors such as the quality of X-ray screening examinations among the general population, and the reduced assessment objectivity of the tuberculosis incidence rate. Conclusions. In assessing the correlation between general incidence and incidence in children under 17 years of age, as well as between incidence and mortality in the Russian Federation, a positive correlation was found with an increasing trend. Such a discrepancy might be due to decreases in the occupational health examination coverage among the general population. Therefore, in the years ahead, we can expect epidemiological indicators to increase incidence and mortality, including child mortality, associated with the insufficient detection of tuberculosis among the population during the COVID-19 pandemic.

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“…Под ЛТИ понимают диагностированное с помощью иммунологических тестов инфицирование микобактериями туберкулеза без клинико-рентгенологического и бактериологического подтверждения наличия заболевания туберкулезом [1,8]. Своевременное выявление ЛТИ и проведение превентивного лечения противотуберкулезными препаратами (ПТП) снижают риск развития активного туберкулеза [10].…”

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Latent tuberculosis infection among university students

Баронова¹,

Aksenova²,

Klevno³

et al. 2020

Tuberk. bolezni lëgk.

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1 ГБУЗ СК «Краевой клинический противотуберкулезный диспансер», г. Ставрополь, РФ 2 ФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФ, Москва, РФ Цель исследования: изучить распространение латентной туберкулезной инфекции (ЛТИ) среди студентов вузов, оценить эффективность превентивного лечения у студентов с ЛТИ. Материалы и методы. В трехэтапное исследование, проведенное в 2016-2019 гг., были включены все студенты, проходящие обучение в высших учебных заведениях г. Ставрополя. На первом этапе в 2016-2017 гг. с использованием внутрикожной пробы с аллергеном туберкулезным рекомбинантным (АТР) обследовано 4 139 студентов.На втором этапе исследования проведен ретроспективный анализ 141 амбулаторной карты студентов с положительными результатами пробы с АТР, взятых под диспансерное наблюдение, из них у 133 проведено превентивное противотуберкулезное лечение.На третьем этапе исследования в 2018-2019 гг. оценены отдаленные результаты превентивного противотуберкулезного лечения.Результаты. Использование пробы с АТР позволило выявить ЛТИ и определить показания для курса превентивного лечения противотуберкулезными препаратами. Среди 133 студентов с ЛТИ, получивших превентивное лечение, случаев заболевания туберкулезом не было; снизилась чувствительность к АТР, что проявилось уменьшением размеров папулы при контроле. Так, через 36 мес. наблюдения из 83 пациентов с гиперергической пробой она сохранилась только у 4.Ключевые слова: туберкулез, студенты, латентная туберкулезная инфекция, проба с аллергеном туберкулезным рекомбинантным, превентивное лечение Для цитирования: Баронова О. Д., Аксенова В. А., Клевно Н. И., Одинец В. С. Латентная туберкулезная инфекция среди студентов, обучающихся в высших учебных заведениях // Туберкулёз и болезни лёгких.Objective: to study the prevalence of latent tuberculosis infection (LTBI) among university students, to evaluate the effectiveness of preventive treatment in students with LTBI. Subjects and methods.In 2016-2019, the three-stage study was conducted that enrolled all university students in the city of Stavropol.In 2016-2017 during the first stage of the study, 4,139 students had tests with tuberculous recombinant allergen (TRA).At the second stage of the study, 141 medical files of students with positive results of TRA tests were retrospectively analyzed, all students were followed up and 133 of them underwent preventive treatment.In 2018-2019 at the third stage of the study, the long-term results of preventive treatment were evaluated.Results. Tests with TRA allowed detecting LTBI and defining indications for preventive treatment with anti-tuberculosis drugs. Among 133 students with LTBI who had preventive treatment, there were no cases of tuberculosis; sensitivity to TRA decreased, which manifested by a decreased induration size during the control test. Thus, in 36 months of follow-up over 83 patients with hyperergic reaction, it persisted only in 4 of them.For citations: Baronova O.D., Аksenova V.А., Klevno N.I., Odinets V...

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Screening for Tuberculosis Infection in Children and Adolescents in Russia – Past, Present, Future

Cited by 13 publications

References 19 publications

Latent tuberculosis infection in children and adolescents in Russia

Latent tuberculosis infection in children and adolescents in Russia

Tuberculosis in the Russian Federation: Dynamics of the Epidemic Indicators before and after COVID-19 Pandemic

Latent tuberculosis infection among university students

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