Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate

Mukherjee, Sudip; Kim, Boram; Cheng, Lauren Y.; Doerfert, Michael David; Li, Jiaming; Hernández, Andrea; Liang, Lily; Jarvis, Maria; Rios, Peter; Ghani, Sofia; Joshi, Ira; Isa, Douglas; Ray, Trisha; Terlier, Tanguy; Fell, Cody; Song, Ping; Miranda, Roberto N.; Oberholzer, José; Zhang, David Y.; Veiseh, Omid

doi:10.1038/s41551-023-01016-2

Cited by 22 publications

(15 citation statements)

References 52 publications

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“…Laborious synthesis [156] Physical interactions Ionic interactions Biocompatible, responsive to pH and ionic strength Mechanical weak [25,55,58,84,115,123,125,131,143,146,[153][154][155]183] Hydrogen bonds Dynamic, biocompatible, suitable for cell encapsulation Mechanical weak, relatively slow crosslinking [66,94,95,97,117,150,164] Hydrophobic interactions…”

Section: Convenient For Peptidesmentioning

confidence: 99%

“…[142] The extent of foreign body response markedly impacts the therapeutic outcomes of hydrogel-assisted cancer therapy and regenerative medicine. Diverse strategies have been demonstrated to module the foreign body response by tuning the polymer chemistry, [143][144][145][146] chirality, charge, [147][148][149][150] stiffness, and porosity of the hydrogels.…”

Section: Immunomodulatory Hydrogels Depending On the Intrinsic Proper...mentioning

confidence: 99%

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Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Zhang,

He,

Chen

2023

Advanced Materials

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The immune system not only acts as a defense against pathogen and cancer cells, but also plays an important role in homeostasis and tissue regeneration. Targeting immune systems is a promising strategy for efficient cancer treatment and regenerative medicine. Current systemic immunomodulation therapies are usually associated with low persistence time, poor targeting to action sites and severe side effects. Due to their ECM‐mimetic nature, tunable properties and diverse bioactivities, hydrogels are intriguing platforms to locally deliver immunomodulatory agents and cells, as well as provide an immunomodulatory microenvironment to recruit, activate and expand host immune cells. In this review, we focus on the design considerations, including polymer backbones, crosslinking mechanisms, physicochemical nature, and immunomodulation‐related components, of the hydrogel platforms. The immunomodulatory effects and therapeutic outcomes in cancer therapy and tissue regeneration of different hydrogel systems are emphasized, including hydrogel depots for delivery of immunomodulatory agents, hydrogel scaffolds for cell delivery, and immunomodulatory hydrogels depending on the intrinsic properties of materials. Finally, the remained challenges in current systems and future development of immunomodulatory hydrogels are discussed.This article is protected by copyright. All rights reserved

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Section: Convenient For Peptidesmentioning

confidence: 99%

Section: Immunomodulatory Hydrogels Depending On the Intrinsic Proper...mentioning

confidence: 99%

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Zhang,

He,

Chen

2023

Advanced Materials

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“…The transplantation of therapeutic allogeneic or xenogeneic cells, within semipermeable devices as a living pharmacy has the potential to treat a range of diseases such as endocrine disorders, autoimmune syndromes, cancers, and neurological degeneration [5][6][7][8][9] . Cell-based therapeutics translation to humans requires high cell densities 2 to enable miniaturized devices of therapeutic value.…”

Section: Mainmentioning

confidence: 99%

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

Lee,

Surendran,

Fleury

et al. 2023

Preprint

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Implantable cell therapies and tissue transplants require sufficient oxygen supply to function and are limited by a delay or lack of vascularization from the transplant host1,2. Exogenous oxygen production can support cells and tissues, such as pancreatic islets and engineered therapeutic cells. Previous oxygenation strategies have targeted gas circulation or decomposition of solid peroxides. These strategies however require bulky implants, transcutaneous supply lines, and are limited in their total oxygen production or regulation3,4. Readily integrated and controlled production of oxygen has eluded cell therapy devices. Here, we show an electrocatalytic approach that enables bioelectronic control of oxygen generation in complex cellular environments to sustain engineered cell viability and therapy production under hypoxic stress and at high cell densities. Nanostructured sputtered iridium oxide serves as an ideal catalyst for oxygen evolution reaction (OER) at neutral pH. It enables a lower OER onset and shows selective oxygen production without evolution of toxic side products over a 300 mV window of operation. This electrocatalytic on site oxygenator (ecO2) can sustain high cell loadings (>60k cells/mm3) in hypoxic conditions in vitro and in vivo. Our results demonstrate that exogenous oxygen production devices can be readily integrated into bioelectronic platforms and enable high cell loadings in smaller device footprints with broad applicability.

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“…7–10 These developments eventually isolate the implants from the host, significantly impairing the functionality of biomaterials and the signal fidelity of implanted biomedical devices. 11–18…”

Section: Introductionmentioning

confidence: 99%

Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels

Liu,

Zhou,

Chen

et al. 2024

Biomater. Sci.

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Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate

Cited by 22 publications

References 52 publications

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels

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