Screening Test of Crude Drug Extract on Anti-HIV Activity

Yamasaki, Katsuhiro; Otake, Toru; Mori, Haruyo; Morimoto, Motoko; Ueba, Noboru; Kurokawa, Yoshiko; Shiota, Kyoko; Yuge, Tomoko

doi:10.1248/yakushi1947.113.11_818

Cited by 31 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also displays anti-HIV-1 activity (Ueba et al, 1993;Yamasaki et al, 1993). Based on the long history of the mixture as an effective treatment for a variety of inflammatory and infectious diseases, shikonin has been extensively characterized using a variety of laboratory methodologies.…”

Section: Introductionmentioning

confidence: 99%

Cellular pharmacology studies of shikonin derivatives

Chen

Yang

Oppenheim

et al. 2002

Phytotherapy Research

371

274

View full text Add to dashboard Cite

The naphthoquinone pigment, shikonin, isolated from Lithospermum erythrorhizon Sieb. et Zucc.(Boraginaceae) and its derivatives are the active components isolated from the Chinese herbal therapeutic, Zicao. Historically, Zicao root extracts have been used to treat macular eruption, measles, sore-throat, carbuncles and burns. Multiple pharmacological actions have been attributed to shikonin, e.g. antiinflammatory, antigonadotropic and anti-HIV-1 activity. In this review, several therapeutic applications of shikonin will be summarized including its pleiotropic, antiinflammatory and antitumour effects. Widely diverse and sometimes conflicting activities have been attributed to shikonin, e.g. wound healing, enhanced granuloma formation, suppression of local acute inflammatory reactions, inhibition of angiogenesis, inhibition of select chemokine ligands, inhibition of DNA topoisomerase activity, inhibition of platelet activation and antimicrobial activity. Comparison of the various reported mechanisms of action for shikonin lead us to hypothesize that shikonin is an effective inhibitor of protein-protein interaction with multiple targets in both the intracellular and extracellular compartments. This general inhibitory effect can account for the broad spectrum of shikonin biological and pharmacological activities.

show abstract

Section: Introductionmentioning

confidence: 99%

Cellular pharmacology studies of shikonin derivatives

Chen

Yang

Oppenheim

et al. 2002

Phytotherapy Research

371

274

View full text Add to dashboard Cite

show abstract

“…et Zucc, Arnebia euchroma (Royle) Johnst, or Arnebia guttata Bunge, is a commonly used herbal medicine in China and other countries. Earlier studies have demonstrated that zicao extract possesses multiple pharmacological activities, including inhibition of human immunodeficiency virus (HIV) type 1 (HIV-1)-induced cytopathology (27,32). Shikonin is a major active chemical component isolated from zicao with a molecular weight of 288 (Fig.…”

mentioning

confidence: 99%

Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1

Chen

Yang²,

Zhang

et al. 2003

Antimicrob Agents Chemother

208

134

View full text Add to dashboard Cite

“…It has been reported that extracts of the spike of P. vulgaris exhibit anti-HIV activity at the adsorption and reverse transcription stages [58]. The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro, P. vulgaris aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cells with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase (RT) [59] [60]. Prunellin, an anti-HIV compound isolated from aqueous extractions of P. vulgaris, is a partially sulfated polysaccharide with the molecular weight of approximately 10,000.…”

Section: Antibacterial and Antivirus Activitiesmentioning

confidence: 99%

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

Ge¹,

Wang²,

Zhang³

et al. 2014

OALib

View full text Add to dashboard Cite

An exhaustive literature survey on the secondary metabolites of widely distributed Prunella vulgaris L. species has been carried out. Triterpenoids, sterols, phenylpropanoids, flavonoids, coumarins, fatty acids, volatile oils and carbohydrates along with some other compounds, have been reported from this species. Many of these compounds have been found to possess significant biological properties, including antihypertensive activity, anticancer activity, anti-lipidemic activity, antibacterial and antivirus activities, anti-inflammatory activities, hypoglycemic effects, heptaprotective effects, antineoplastic activities, etc. P. vulgaris might offer a rich natural source with relative cheap price for developing new anti-neoplastic drugs.

show abstract

Screening Test of Crude Drug Extract on Anti-HIV Activity

Cited by 31 publications

References 0 publications

Cellular pharmacology studies of shikonin derivatives

Cellular pharmacology studies of shikonin derivatives

Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

Contact Info

Product

Resources

About