Screening the critical protein subnetwork to delineate potential mechanisms and protective agents associated with arsenic-induced cutaneous squamous cell carcinoma: A toxicogenomic study

Koushki, Mehdi; Amiri-Dashatan, Nasrin; Rezaei-Tavirani, Mostafa; Robati, Reza M.; Fateminasab, Fatemeh; Rahimi, Shadi; Razzaghi, Zahra; Farahani, Masoumeh

doi:10.1016/j.fct.2024.114451

Cited by 2 publications

(1 citation statement)

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“…However, the roles of CHD modulators in BrCa are not fully understood. Bioinformatics analysis has become an increasingly popular method among researchers for identifying novel diagnostic, prognostic, and treatment biomarkers in various types of human cancers [21,22,8,23]. Therefore, the lack/poor of information about a link between CHD family genes and BrCa prompted us to investigate the roles of CHD family genes to discover potential prognostic markers through analysis of CHD family expression in BrCa by mining UALCAN, TIMER and Kaplan-Meier plotter databases.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for Chromodomain-Helicase-DNA-Binding Proteins in Breast Tumor

Hasanlu,

Amiri-Dashatan,

Farahani

et al. 2024

Asian Pac J Cancer Prev

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Background: Several recent studies suggest that chromodomain-helicase -DNA-binding domains (CHDs) are linked with cancers. We explored the association between chromodomain-Helicase-DNA-binding domain proteins and breast cancer (BrCa) and introduced potential prognostic markers using various databases. Materials and Methods: We analyzed the expression of the CHD family and their prognostic value in BrCa by mining UALCAN, TIMER, and Kaplan-Meier plotter databases. The association of CHD expression and immune infiltrating abundance was studied via the TIMER database. In addition, microRNAs related to the CHD family were identified by using the MirTarBase online database. Results: The present study indicated that compared to normal tissues, BrCa tissues showed increased mRNA levels of CHD3/4/7 but decreased CHD2/5/9 expression. Interestingly, We also found a positive correlation between CHD gene expression and the infiltration of macrophage, neutrophil, and dendritic cells in BrCa, except CHD3/5. The Kaplan-Meier Plotter analysis suggested that high expression levels of CHD1/2/3/4/6/8/9 were significantly related to shorter relapse-free survival (RFS), while higher mRNA expression of CHD1, CHD2, CHD8, and CHD9 was significantly associated with longer overall survival of BrCa patients. The miRNAs of hsa-miR-615-3p and hsa-let-7b-5p were identified as being more correlated with the CHD family. Conclusion: The altered expression of some CHD members was significantly related to clinical cancer outcomes, and CHD1/2/8/9 could serve as potential prognostic biomarkers to improve the survival of BrCa patients. However, to evaluate the studied CHD members in detail are needed further investigations including experimental validation.

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Section: Introductionmentioning

confidence: 99%