Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review

Tao, Yadong; Chen, Yu; Zheng, Qingyin; Zhang, Xu; Wang, Wei; Ni, Guangjian

doi:10.3389/fnagi.2021.677090

Cited by 3 publications

(3 citation statements)

References 128 publications

(129 reference statements)

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“…Auditory event-related potentials have shown significant abnormalities in both amplitude and latency in individuals living with Alzheimer’s disease and mild cognitive impairment. 28 , 29 , 51 Specifically, a meta-analysis conducted by Tarawneh et al showed the promising role of these potentials (eg, P300) in discriminating between those at higher risk of cognitive decline from normal-ageing individuals. 29 Biomarkers of cognitive impairment may also be reflected in clinical measures of listening effort (eg, pupillometry).…”

Section: Discussionmentioning

confidence: 99%

“…Two systematic reviews have identified the use of auditory event-related potentials as biomarkers for cognitive impairment and Alzheimer’s disease. 28 , 29 Auditory-event-related potentials (eg, P200; P300) were shown to be valuable biomarkers of Alzheimer’s disease, and have the potential to be integrated as a complementary assessment as part of a clinical neuropsychological test battery. 28 An investigation into routine clinical practice is needed to determine the effectiveness of current measures and assess the practicality of using biomarkers in clinic.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Assessment Tools for the Detection of Cognitive Impairment and Hearing Loss in the Ageing Population: A Scoping Review

Ferguson,

Nakano,

Jayakody

2023

CIA

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Objective There is a strong association between cognitive impairment and hearing loss, both highly prevalent in the ageing population. Early detection of both hearing loss and cognitive impairment is essential in the management of these conditions to ensure effective and informed decisions on healthcare. The main objective was to identify existing and emerging cognitive and auditory assessment tools used in clinical settings (eg, memory clinics, audiology clinics), which manage the ageing population. Methods A scoping review of peer-reviewed publications and results were reported according to the PRISMA-ScR guidelines. Results A total of 289 articles were selected for data extraction. The majority of studies (76.1%) were conducted in 2017 or later. Tests of global cognitive function (ie, Mini-Mental State Exam, Montreal Cognitive Assessment) were the most commonly used method to detect cognitive impairment in hearing healthcare settings. Behavioral hearing testing (ie, pure-tone audiometry) was the most commonly used method to detect hearing loss in cognitive healthcare settings. Objective, physiological measures were seldom used across disciplines. Conclusion Preferences among clinicians for short, accessible tests likely explain the use of tests of global cognitive function and behavioral hearing tests. Rapidly evolving literature has identified inherent limitations of administering global cognitive function tests and pure-tone testing in an ageing population. Using electrophysiological measures as an adjunct to standard methods of assessment may provide more reliable information for clinical recommendations in those with cognitive and hearing impairment, and subsequently achieve better healthcare outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Assessment Tools for the Detection of Cognitive Impairment and Hearing Loss in the Ageing Population: A Scoping Review

Ferguson,

Nakano,

Jayakody

2023

CIA

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“…Moreover, ARHL has been associated with social isolation and depression, and it has been recognized as a modifiable risk factor for dementia (Livingston et al, 2017(Livingston et al, , 2020. However, the mechanisms that relate to hearing loss and cognitive decline are complex and still under research (Yue et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Speech Perception and Dichotic Listening Are Associated With Hearing Thresholds and Cognition, Respectively, in Unaided Presbycusis

Vergara

Moreno‐Gómez

et al. 2022

Front. Aging Neurosci.

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Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which affects oral communication, especially in background noise, and has been associated with social isolation, depression, and cognitive decline. However, the mechanisms that relate hearing loss with cognition are complex and still elusive. Importantly, recent studies show that the use of hearing aids in presbycusis, which is its standard management, can induce neuroplasticity and modify performance in cognitive tests. As the majority of the previous studies on audition and cognition obtained their results from a mixed sample of subjects, including presbycusis individuals fitted and not fitted with hearing aids, here, we revisited the associations between hearing loss and cognition in a controlled sample of unaided presbycusis. We performed a cross-sectional study in 116 non-demented Chilean volunteers aged ≥65 years from the Auditory and Dementia study cohort. Specifically, we explored associations between bilateral sensorineural hearing loss, suprathreshold auditory brain stem responses, auditory processing (AP), and cognition with a comprehensive neuropsychological examination. The AP assessment included speech perception in noise (SIN), dichotic listening (dichotic digits and staggered spondaic words), and temporal processing [frequency pattern (FP) and gap-in-noise detection]. The neuropsychological evaluations included attention, memory, language, processing speed, executive function, and visuospatial abilities. We performed an exploratory factor analysis that yielded four composite factors, namely, hearing loss, auditory nerve, midbrain, and cognition. These four factors were used for generalized multiple linear regression models. We found significant models showing that hearing loss is associated with bilateral SIN performance, while dichotic listening was associated with cognition. We concluded that the comprehension of the auditory message in unaided presbycusis is a complex process that relies on audition and cognition. In unaided presbycusis with mild hearing loss (<40 dB HL), speech perception of monosyllabic words in background noise is associated with hearing levels, while cognition is associated with dichotic listening and FP.

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Single cell RNA sequencing provides novel cellular transcriptional profiles and underlying pathogenesis of presbycusis

Zhang,

Xiang,

Sun

et al. 2024

BMC Med Genomics

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Age-related hearing loss (ARHL) or presbycusis is associated with irreversible progressive damage in the inner ear, where the sound is transduced into electrical signal; but the detailed mechanism remains unclear. Here, we sought to determine the potential molecular mechanism involved in the pathogeneses of ARHL with bioinformatics methods. A single-cell transcriptome sequencing study was performed on the cochlear samples from young and aged mice. Detection of identified cell type marker allowed us to screen 18 transcriptional clusters, including myeloid cells, epithelial cells, B cells, endothelial cells, fibroblasts, T cells, inner pillar cells, neurons, inner phalangeal cells, and red blood cells. Cell-cell communications were analyzed between young and aged cochlear tissue samples by using the latest integration algorithms Cellchat. A total of 56 differentially expressed genes were screened between the two groups. Functional enrichment analysis showed these genes were mainly involved in immune, oxidative stress, apoptosis, and metabolic processes. The expression levels of crucial genes in cochlear tissues were further verified by immunohistochemistry. Overall, this study provides new theoretical support for the development of clinical therapeutic drugs. Supplementary Information The online version contains supplementary material available at 10.1186/s12920-024-02001-7.

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Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review

Cited by 3 publications

References 128 publications

Clinical Assessment Tools for the Detection of Cognitive Impairment and Hearing Loss in the Ageing Population: A Scoping Review

Clinical Assessment Tools for the Detection of Cognitive Impairment and Hearing Loss in the Ageing Population: A Scoping Review

Speech Perception and Dichotic Listening Are Associated With Hearing Thresholds and Cognition, Respectively, in Unaided Presbycusis

Single cell RNA sequencing provides novel cellular transcriptional profiles and underlying pathogenesis of presbycusis

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