Scrotal wall metastasis from a primary lung adenocarcinoma

Coussa-Koniski, Marie-Louise; Maalouf, Pia A.; Raad, Nehme E.; Bejjani, Noha

doi:10.1016/j.rmcr.2015.05.002

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Lung cancer is one of the most common lethal malignancies and lung adenocarcinoma accounts for more than 80% 1 , 2 . Metastasis is the major factor associated with poor prognosis of lung adenocarcinoma, in which lymph node metastasis is an important way 3 , 4 . It is thus necessary to explore an optimal molecular target for suppressing the lymph node metastasis and improving the therapeutic ratio.…”

Section: Introductionmentioning

confidence: 99%

CCR7 promote lymph node metastasis via regulating VEGF-C/D-R3 pathway in lung adenocarcinoma

Yu¹,

Tao²,

Hu³

et al. 2017

J. Cancer

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Lymph node metastasis is still an important issue in metastatic process of lung adenocarcinoma. C-C chemokine receptor 7 (CCR7) has been proved to be closely associated with the metastasis of lung adenocarcinoma, and the mechanism is poorly understood. In order to investigate the relationship between CCR7 and lymph node metastasis in lung adenocarcinoma, and to explore the role of CCR7 in treating lung adenocarcinoma, 40 clinical specimens were collected to define the relationship between CCR7 and lymph node metastasis in lung adenocarcinoma by immunohistochemistry. The siRNA was used to suppress CCR7 expression in A549 cells. The scratch test, transwell test, qRT-PCR, western blot, flow cytometry and immunofluorescence were used to investigate the lymph node metastasis-related function of CCR7 in vitro . The athymic mice subcutaneous injection was used to research lung adenocarcinoma formation in vivo . Clinical case studies show that higher expression of CCR7 in lung adenocarcinoma tissues was associated with a higher lymph node metastasis. Inhibition of expression of CCR7 can reduce the migration and invasion and suppress the expression of VEGF-C, VEGF-D and VEGF-R3 in vitro and in vivo . Moreover, CCR7 silence also suppressed WNT and p-ERK pathways in vitro . All the results indicate that CCR7 can promote lymph node metastasis in lung adenocarcinoma by regulating VEGF-C/D-R3 pathway. Thus CCR7 is proposed to be a potential prediction for poor prognosis of lung adenocarcinoma, and a therapeutic target for lymph node metastasis.

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Section: Introductionmentioning

confidence: 99%

CCR7 promote lymph node metastasis via regulating VEGF-C/D-R3 pathway in lung adenocarcinoma

Yu¹,

Tao²,

Hu³

et al. 2017

J. Cancer

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show abstract

“…2,3 Moreover, lung cancer, with many variants, frequently metastasize to bone, brain, lung and liver, and drugs that target distant metastases oen do not work in the adjuvant settings, 4 or worse, wreak havoc on healthy cells and tissues, 5,6 causing poor prognosis and high mortality. 7,8 Thus, new therapies that overcome the current obstacles such as drug resistance, side effects, and poor specicity provide hope for the treatment of NSCLC in the future.…”

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confidence: 99%