SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy

De-Colle, Chiara; Mönnich, David; Welz, Stefan; Boeke, Simon; Sipos, Bence; Fend, Falko; Mauz, Paul-Stefan; Tinhofer, Ingeborg; Budach, Volker; Jawad, Jehad Abu; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Grosu, Anca‐Ligia; Abdollahi, Amir; Debus, Jürgen; Bayer, Christine; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E.; Lohaus, Fabian; Linge, Annett; Krause, Mechthild; Baumann, Michaël; Zips, Daniel; Menegakis, Apostolos

doi:10.1016/j.ctro.2017.06.004

Cited by 18 publications

(18 citation statements)

References 61 publications

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“…For further patient stratification beyond the HPV status, additional biomarker analyses are currently being carried out within this DKTK-ROG study covering multiple radiobiological aspects [11,28,[36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC

Linge

Schötz²,

Löck³

et al. 2018

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 99%

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC

Linge

Schötz²,

Löck³

et al. 2018

Radiotherapy and Oncology

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“…MRP2 protein expression and RB protein expression were also found to be independently associated with reduced local control in patients who received CCRT . Another study evaluated stromal cell‐derived factor 1 (SDF‐1)/CXCR4 and demonstrated predictive ability with respect to locoregional control and survival in 141 patients who underwent surgery and adjuvant CCRT . It should be noted, however, that some of these studies failed to discriminate between resistance to RT vs chemoresistance.…”

Section: Biomarkers In Hnscc Tumor Tissuesmentioning

confidence: 99%

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Hsieh

Wang

et al. 2019

Head & Neck

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Background Biomarkers in head and neck squamous cell carcinoma (HNSCC) emerge rapidly in recent years, especially for new targeted therapies and immunotherapies. Methods Recent, relevant peer‐reviewed evidence were critically reviewed and summarized. Results This review article briefly introduces essential biomarker concepts, including purposes and classifications (predictive, prognostic, and diagnostic markers), and the phases of biomarker development. We summarize current biomarkers in order of clinical utility; p16 and human papillomavirus status remain the most important and validated biomarkers in HNSCC. The rationale for biomarker study design continues to evolve with technological advances, especially whole‐exome or whole‐genomic sequencing. Noninvasive body fluid and liquid biopsy biomarkers appear to hold strong potential for development as tools for early cancer detection, cancer diagnosis, monitoring of disease recurrence, and outcome prediction. In light of discrepancies among different technologies, standardized approaches are needed. Conclusion Biomarkers from cancer tissue or blood in HNSCC could direct new anticancer therapies.

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“…Studies have reported that CXCR4 expression in primary tumors is involved not only in the local recurrence of head and neck cancer (22) but also in cervical lymph node metastasis and distant metastasis of hypopharyngeal cancer (14). Moreover, SDF-1/CXCR4 expression has been shown to be a negative prognostic factor after postoperative radiotherapy for head and neck cancer (21,41).…”

Section: Discussionmentioning

confidence: 99%

“…Research models conducted in head and neck SCC (HNSCC) cell lines or HNSCC nude mice have shown that the expression of SDF-1/CXCR4 promotes cell motility, proliferation, and metastasis via the upregulation of various pathways, such as ERK 1/2, NF-kB, and matrix metalloproteinase (MMP) (14)(15)(16)(17)(18). In addition, some clinical data have suggested that SDF-1/CXCR4-positive HNSCC tumors have high metastatic potential and poor outcomes (14,(19)(20)(21)(22). However, research on its correlation with other tumor-promoting factors is lacking.…”

Section: Introductionmentioning

confidence: 99%

SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx

et al. 2020

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Hypopharyngeal squamous cell carcinoma (SCC) has a poor prognosis due to local invasion and metastasis. The chemokine receptor CXC chemokine receptor type 4 (CXCR4) and its ligand, stromal cell-derived factor 1 (SDF-1), play roles in tumor progression through unclear mechanisms. For the present study, we used a hypopharyngeal SCC cell line, FaDu, expressing CXCR4. We found that SDF-1 promotes migration and invasion of the FaDu cells. In addition, AMD3100, a specific antagonist of CXCR4, inhibited the binding of SDF-1 to CXCR4, resulting in a significant decrease in the FaDu cell migration induced by SDF-1. Stimulation of CXCR4 with SDF-1 induced an increase in the expression of CD147, a cell membrane protein; and this CD147 upregulation was abrogated by AMD3100. CD147 function-blocking antibodies also abolished the SDF-1-induced FaDu invasiveness. Our results suggested that SDF-1/CXCR4 mediate hypopharyngeal SCC cell migration and that CD147 is involved in the SDF-1/CXCR4-related tumor progression.

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SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy

Cited by 18 publications

References 61 publications

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx

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