SE-ECL on CMOS: a miniaturized electrochemiluminescence biosensor

Abbasi, Reza; Liu, Juanjuan; Suarasan, Sorina; Wachsmann‐Hogiu, Sebastian

doi:10.1039/d1lc00905b

Cited by 18 publications

(8 citation statements)

References 59 publications

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“…High or low levels of them can lead to abnormal changes in the body. Some molecules, such as amino acids, 91 vitamins, 56,92 lactate, 93 dopamine (DA), 30,94,95 choline, cholesterol, 60,96 uric acid (UA), 97 glucose, 19,32,[98][99][100][101] and 3-nitrotyrosine (3-NT), 59 have already been detected by using ECL-POCT devices. Some devices are also designed to achieve high throughput analysis.…”

Section: Detection Of Physiological Signsmentioning

confidence: 99%

“…The SNM allows the electrode to analyze complex biological samples such as urine and rat brain homogenates because of its anti-contamination properties. Besides, Wachsmann-Hogiu et al 97 also developed a device based on a single electrode system for UA, integrating it with a complementary metal-oxide-semiconductor (CMOS) and a touchscreen liquid crystal display (LCD). Sample handling and data collection can be accomplished on the same platform.…”

Section: Applications Of Ecl-poct Devicesmentioning

confidence: 99%

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Electrochemiluminescence devices for point-of-care testing

Ying

Zhou

et al. 2023

Sens. Diagn.

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Section: Detection Of Physiological Signsmentioning

confidence: 99%

Section: Applications Of Ecl-poct Devicesmentioning

confidence: 99%

Electrochemiluminescence devices for point-of-care testing

Ying

Zhou

et al. 2023

Sens. Diagn.

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“…However, the eye does not provide accurate quantitative results, and therefore, electronic detectors are used when quantitation is important. For luminescence, cell phone cameras that utilize a CMOS imaging sensor may be sufficient when the signal intensity is high, as demonstrated in our previous work [ 107 , 108 ]. The detection sensitivity relies on the capabilities of the CMOS sensor, such as quantum efficiency, spectral response, and noise.…”

Section: Fundamentals Of Photonic Biosensorsmentioning

confidence: 99%

“…Moreover, the configuration of the instrument, such as the setup of optical components, will also affect the sensing performance. As an example, in one of our previous articles, we demonstrate an improvement in sensitivity for electrochemiluminescence detection by combining a single electrode system with a microfluidic platform that is prepared on the surface of a CMOS sensor to achieve higher photon collection efficiency [ 108 ].…”

Section: Fundamentals Of Photonic Biosensorsmentioning

confidence: 99%

Progress and Challenges of Point-of-Need Photonic Biosensors for the Diagnosis of COVID-19 Infections and Immunity

Liu

Wachsmann‐Hogiu

2022

Biosensors

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The new coronavirus disease, COVID-19, caused by SARS-CoV-2, continues to affect the world and after more than two years of the pandemic, approximately half a billion people are reported to have been infected. Due to its high contagiousness, our life has changed dramatically, with consequences that remain to be seen. To prevent the transmission of the virus, it is crucial to diagnose COVID-19 accurately, such that the infected cases can be rapidly identified and managed. Currently, the gold standard of testing is polymerase chain reaction (PCR), which provides the highest accuracy. However, the reliance on centralized rapid testing modalities throughout the COVID-19 pandemic has made access to timely diagnosis inconsistent and inefficient. Recent advancements in photonic biosensors with respect to cost-effectiveness, analytical performance, and portability have shown the potential for such platforms to enable the delivery of preventative and diagnostic care beyond clinics and into point-of-need (PON) settings. Herein, we review photonic technologies that have become commercially relevant throughout the COVID-19 pandemic, as well as emerging research in the field of photonic biosensors, shedding light on prospective technologies for responding to future health outbreaks. Therefore, in this article, we provide a review of recent progress and challenges of photonic biosensors that are developed for the testing of COVID-19, consisting of their working fundamentals and implementation for COVID-19 testing in practice with emphasis on the challenges that are faced in different development stages towards commercialization. In addition, we also present the characteristics of a biosensor both from technical and clinical perspectives. We present an estimate of the impact of testing on disease burden (in terms of Disability-Adjusted Life Years (DALYs), Quality Adjusted Life Years (QALYs), and Quality-Adjusted Life Days (QALDs)) and how improvements in cost can lower the economic impact and lead to reduced or averted DALYs. While COVID19 is the main focus of these technologies, similar concepts and approaches can be used and developed for future outbreaks of other infectious diseases.

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“…The ideal point-of-care device is a portable “sample-in-answer-out” system, emphasizing operational simplicity. However, the majority of diagnostic technologies require specialized instrumentation and offer limited applicability in point-of-care scenarios that demand quantitative diagnostic-level performance. − To address this challenge, certain biosensors can be adapted for point-of-care applications.…”

Section: Introductionmentioning

confidence: 99%

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti₃C₂ MXene-Modified Single Electrode Electrochemical System on Raspberry Pi

Firoozbakhtian,

Hosseini,

Guan

et al. 2023

Anal. Chem.

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Point-of-care testing plays a crucial role in diagnostics within resourcepoor areas, necessitating the utilization of portable and user-friendly devices. The adaptation of biosensors for point-of-care applications requires careful considerations, such as miniaturization, cost-effectiveness, and streamlined sample processing. In recent years, the electrochemiluminescence (ECL) immunoassay has gained significant attention due to its visual detection capabilities and ability to facilitate high-throughput analysis. However, the development of a practical and cost-effective ECL device remains a challenging task. This study presents the development of an integrated MXenemodified single-electrode electrochemical system (SEES) for visual and high-throughput ECL immunoassays incorporating a Raspberry Pi system. The SEES was designed by affixing a plastic sticker with multiple perforations onto a single carbon ink screenprinted electrode, which operates based on a resistance-induced potential difference. Leveraging the excellent adsorption and bioaffinity properties of the carbon ink screenprinted electrode, effective immobilization of antibodies was achieved. Furthermore, the incorporation of Co−Pt nanoparticles enhanced the ECL intensity and electron transfer kinetics, enabling the sensitive detection of SARS-CoV-2. The developed system comprised 18 individual reaction cells, allowing for simultaneous analysis while maintaining sample isolation. Impressively, the system achieved a remarkable minimum virus detection limit of 10 −14 g mL −1 , accompanied by a high R 2 value of 0.9798. These findings highlight the promising potential of our developed system for efficient point-of-care testing in resource-limited settings.

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SE-ECL on CMOS: a miniaturized electrochemiluminescence biosensor

Abstract: Biosensors exhibit high potential for the detection of analytes of interest at the point-of-need. Over the past two decades, combination of novel biosensing systems – such as electrochemiluminescence (ECL) biosensors...

Cited by 18 publications

References 59 publications

Electrochemiluminescence devices for point-of-care testing

Electrochemiluminescence devices for point-of-care testing

Progress and Challenges of Point-of-Need Photonic Biosensors for the Diagnosis of COVID-19 Infections and Immunity

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti₃C₂ MXene-Modified Single Electrode Electrochemical System on Raspberry Pi

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SE-ECL on CMOS: a miniaturized electrochemiluminescence biosensor

Abstract: Biosensors exhibit high potential for the detection of analytes of interest at the point-of-need. Over the past two decades, combination of novel biosensing systems – such as electrochemiluminescence (ECL) biosensors...

Cited by 18 publications

References 59 publications

Electrochemiluminescence devices for point-of-care testing

Electrochemiluminescence devices for point-of-care testing

Progress and Challenges of Point-of-Need Photonic Biosensors for the Diagnosis of COVID-19 Infections and Immunity

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti3C2 MXene-Modified Single Electrode Electrochemical System on Raspberry Pi

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Product

Resources

About

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti₃C₂ MXene-Modified Single Electrode Electrochemical System on Raspberry Pi