Se<sup>75</sup>-Selenomethionine for Visualization of the Pancreas by Isotope Scanning

Blau, Monte; Bender, Merrill A.

doi:10.1148/78.6.974

Cited by 104 publications

(15 citation statements)

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“…A percentage in close agreement with that of other authors (Blau and Bender, 1962;Burke and Goldstein, 1964;and Bouchier, 1967). Other papers have reported a higher percentage of scans with clear visualization of the pancreas (Kakehi, Tateno, Uchiyama, and Tsuchiya, 1967) but the method of these authors has proved less effective in our hands.…”

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confidence: 90%

Experiences with data processing to separate the images in pancreatic scanning

Charlesworth¹,

Hj²,

Br³

et al. 1970

Gut

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SUMMARY In many subjects, overlap of the image of the pancreas by the liver image makes clear delineation of the pancreas uncertain. A dual isotope technique was evolved with a ratio substract system. Experiments in vitro with a phantom liver and pancreas successfully erased the liver image from the final printout. In vivo, however, the results were in many cases unsatisfactory. A detailed statistical analysis of the data has provided an explanation for these differences.

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confidence: 90%

Experiences with data processing to separate the images in pancreatic scanning

Charlesworth¹,

Hj²,

Br³

et al. 1970

Gut

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“…Methionine, being an amino acid, localizes in the exocrine portion of the pancreas and reflects the metabolic activity and turnover in this area. Studies in the early 1960s by Blau and coworkers [2][3][4] led to the introduction of 75Se methionine whose biologic properties are similar to methionine. They showed that 6% of the administered dose localized in the dog pancreas at 2 h.…”

Section: Pancreas Imagingmentioning

confidence: 99%

The role of radionuclide imaging in disease of the alimentary tract

Freeman

Rosenthall

1976

Gastrointest Radiol

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The current status of radionuclide imaging studies of the liver, spleen, and pancreas is reviewed. Although current instrumentation and radiopharmaceuticals allow considerably better images than in the past, the overall accuracy of detecting liver metastases remains at 80%. The specificity of detecting hepatic space occupying disease has been enhanced by additional radionuclide studies which reveal the vascular and metabolic properties of the lesion.--The frequency of spleen imaging has increased since 99mTc-labeled colloids have been used. In most instances, it is obtained as a coincidental portion of the liver scintigraphic examination although it has significant primary indications such as in the elucidation of masses in or trauma to the left upper quadrant of the abdomen.--Selenium-75 selenomethionine pancreatic scintigraphy is best performed with serial Anger Camera images. Interfering hepatic activity is best removed by electronic subtraction techniques; if available. Careful attention to patient selection for the procedure is important. The mean true-positive and negative rates are 86% and 20%, respectively.

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“…However, evidence has been obtained that indicates that methionine and selenomethionine may follow different pathways (Awward et al 1966;Atkins et al 1971). Se 75 -selenomethionine has found wide application, ranging from its use in measuring protein turnover rates in young and old rats (Yousef & Johnson 1970) to its use in pancreas scanning (Blau & Bender 1962). No literature exists on the distribution of selenomethionine in individual liver, kidney, and blood proteins at different times after injection.…”

Section: Nz Journal Of Agricultllral Research 16: 115-27mentioning

confidence: 99%

A comparison of the metabolism of intravenously injected sodium selenite, sodium selenate, and selenomethionine in rats

Millar¹,

Gardiner²,

Sheppard³

1973

New Zealand Journal of Agricultural Research

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Rats were injected with Se 75 -sodium selenite, Se75-sodium selenate, and Se75-selenomethionine, and the distributions of Se75 in tissues, and in proteins isolated from plasma, liver supernatants, and kidney supernatants, were studied as a function of time.The livers of rats injected with selenite had a much greater initial Se75 concentration than those from rats receiving selenate. Kidneys of rats injected with selenite had a peak Se 75 concentration in the sample taken 1 hr after injection; this was followed by a rapid decline. Kidneys from rats injected with selenate had an almost constant Se75 level in all samples from 1 hr to 7 days. In other tissues the Se 75 activities for rats injected with selenite were similar to those for rats injected with selenate. As has been reported elsewhere the tissues retaining the highest Se 75 levels were the livers, kidneys, and adrenals.Rats injected with selenomethionine contained greater Se 75 concentrations in the pancreas than rats injected with selenite or selenate.Dialysis of plasma and liver and kidney supernatants against isotonic saline showed that at I hr after injection selenomethionine was associated with protein to a greater extent than was selenite or selenate. Disulphide-cleaving reagents (mercaptoethanol and cysteine) and urea were effective in releasing Se75 from liver, kidney, and plasma proteins from rats injected with either selenomethionine, selenite, or selenate. Se i ;, distribution patterns in liver. kidney, and plasma proteins separated by gel filtration or disc-electrophoresis were very similar for samples collected at I day, 3 days, and 7 days after injection of rats with either selenite, selenate, or selenomethionine. If, as has been rroposed, selenium from selenite or selenate is present in protein as selenotrisulphide, this finding suggests that selenomethionine may not be incorporated into protein intact.115

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Se⁷⁵-Selenomethionine for Visualization of the Pancreas by Isotope Scanning

Cited by 104 publications

References 0 publications

Experiences with data processing to separate the images in pancreatic scanning

Experiences with data processing to separate the images in pancreatic scanning

The role of radionuclide imaging in disease of the alimentary tract

A comparison of the metabolism of intravenously injected sodium selenite, sodium selenate, and selenomethionine in rats

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Se75-Selenomethionine for Visualization of the Pancreas by Isotope Scanning

Cited by 104 publications

References 0 publications

Experiences with data processing to separate the images in pancreatic scanning

Experiences with data processing to separate the images in pancreatic scanning

The role of radionuclide imaging in disease of the alimentary tract

A comparison of the metabolism of intravenously injected sodium selenite, sodium selenate, and selenomethionine in rats

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Product

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Se⁷⁵-Selenomethionine for Visualization of the Pancreas by Isotope Scanning