Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca<sup>2+</sup>/PKA signaling pathway

Luo, Xianliang; Liu, Wangxin; Zheng, Baodong; Zheng, Yafeng; Zhao, Minjie; Feng, Fengqin; Liu, Ling

doi:10.1039/d3fo03031h

Food Funct.

2023

DOI: 10.1039/d3fo03031h

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Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca²⁺/PKA signaling pathway

Xianliang Luo,

Wangxin Liu,

Baodong Zheng

et al.

Abstract: Sea cucumber peptide (SCP) has been proven to have many active functions, but its impact and mechanism on testosterone synthesis are not yet clear. This study attempts to explore the...

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2024

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Cited by 2 publications

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Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

He,

Peng,

Zeng

et al. 2024

Food Bioscience

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Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

He,

Peng,

Zeng

et al. 2024

Food Bioscience

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Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats

Askari,

Jafarzadeh Shirazi,

Ahmadi

et al. 2024

Asian Pacific Journal of Reproduction

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Objective: To explore the potential therapeutic impact of an alcoholic extract derived from the sea cucumber (Holothuria parva) on letrozole-induced polycystic ovary syndrome (PCOS) in adult female Sprague-Dawley rats. Methods: Sixteen female rats, aged 8 to 10 weeks, with a mean weight of (200±20) g, were randomly assigned to four groups: the control, PCOS, and two treatment groups receiving sea cucumber extract and metformin, respectively. PCOS was induced by administering letrozole at a dose of 1 mg/kg to initiate the treatment period at 60 days of age. The study spanned four weeks, during which ovarian and uterine tissues were collected for histological examination, and blood samples were collected for hormonal levels. Results: Significant decreases in luteinizing hormone/follicle stimulating hormone (LH/FSH) and testosterone and increases progesterone levels among groups treated with sea cucumber extract were observed. While no significant differences were observed in follicle-stimulating hormone (FSH) and testosterone levels, the distinctive variations in key hormones suggested a potential role for sea cucumber alcoholic extract in ameliorating PCOS symptoms. Conclusions: This research highlights the moderate efficacy of sea cucumber extract as a therapeutic intervention for PCOS, providing a novel perspective in the search for effective remedies. The observed hormonal alterations, particularly in LH, estradiol, and progesterone, underscore the need for further exploration into the underlying mechanisms and for optimizing the application of sea cucumber extract in PCOS management.

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Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca²⁺/PKA signaling pathway

Abstract: Sea cucumber peptide (SCP) has been proven to have many active functions, but its impact and mechanism on testosterone synthesis are not yet clear. This study attempts to explore the...

Cited by 2 publications

References 46 publications

Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats

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Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca2+/PKA signaling pathway

Abstract: Sea cucumber peptide (SCP) has been proven to have many active functions, but its impact and mechanism on testosterone synthesis are not yet clear. This study attempts to explore the...

Cited by 2 publications

References 46 publications

Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats

Contact Info

Product

Resources

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Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca²⁺/PKA signaling pathway