Seagrass as a potential source of natural antioxidant and anti-inflammatory agents

Yuvaraj, N.; Kanmani, Paulraj; Satishkumar, Ramraj; Paari, Alagesan; Pattukumar, V.; Arul, Venkatesan

doi:10.3109/13880209.2011.611948

Cited by 43 publications

(33 citation statements)

References 40 publications

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“…The R. cirrhosa extract exhibited an IC50 value of 152.9-175.7 μg/mL, which is considered low to moderate radical scavenging activity [34]. These results are comparable to antioxidant activities of crude extracts of the seagrasses Halodule ovalis (IC50 130 μg/mL) [35], Syringodium isoetifolium (IC50 96.34 μg/mL), Enhalus acoroides (IC50 115.79 μg/mL), Cymodocea rotundata (IC50 123.72 μg/mL) and Thalassia hemprichii (IC50 214.68 μg/mL) [36]. However, after partition with ethyl acetate, the aqueous phase of R. cirrhosa exhibited very strong radical scavenging activity, with an IC50 value of 31.8 ± 3.2 μg/mL.…”

Section: Dpph Radical Scavenging Of Ruppia Polyphenolsmentioning

confidence: 89%

“…If the inflammation response is prolonged, it can lead to numerous chronic diseases like diabetes, cancer, cardiovascular and neurodegenerative diseases. 18,[35][36][37] Many flavonoids, such as apigenin, luteolin, kaempferol and quercetin, are reported to possess anti-inflammatory and analgesic effects, [37][38] in that way contributing to the inhibition of the inflammation process and improving the immune system.…”

Section: Biological Activitiesmentioning

confidence: 99%

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Characterization and seasonal variation of individual flavonoids in Zostera marina and Zostera noltii from Norwegian coastal waters

Enerstvedt

Lundberg

Sjøtun

et al. 2017

Biochemical Systematics and Ecology

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Section: Dpph Radical Scavenging Of Ruppia Polyphenolsmentioning

confidence: 89%

Section: Biological Activitiesmentioning

confidence: 99%

Characterization and seasonal variation of individual flavonoids in Zostera marina and Zostera noltii from Norwegian coastal waters

Enerstvedt

Lundberg

Sjøtun

et al. 2017

Biochemical Systematics and Ecology

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“…[30][31][32] Studies on the anti-inflammatory activity of solvent extracts of seaweeds and seagrass have been conducted previously. 16,20,33,34 However, very few studies have investigated the anti-inflammatory activity of sulfated polysaccharides obtained from seaweeds. 18,35,36 Currently, sulfated polysaccharides of different seaweed species provide new analgesic and anti-inflammatory agents.…”

Section: Discussionmentioning

confidence: 99%

“…19 We reported the existence of the anti-inflammatory activity in seagrass Halophila ovalis methanol extract. 20 However, there is no single report about the biological activities of sulfated polysaccharides from seagrass H. ovalis until now. Therefore, the present study was undertaken to determine the anti-inflammatory and analgesic activity of sulfated polysaccharides from brown seaweed S. wightii and seagrass H. ovalis in experimental animal models.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Activities of Sargassum wightii and Halophila ovalis Sulfated Polysaccharides in Experimental Animal Models

Yuvaraj

Kanmani²,

Satishkumar

et al. 2013

Journal of Medicinal Food

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The present study investigated the effects of sulfated polysaccharides from brown seaweed Sargassum wightii (Sw-SP) and seagrass Halophila ovalis (Ho-SP) in nociceptive and inflammatory models. In the formalin test, Sw-SP and Ho-SP significantly reduced licking time in both phases of the test at a dose of 10 mg/kg. In the hot plate test, the antinociceptive effect was observed only in animals treated with 10 mg/kg of Sw-SP and 5, 10 mg/kg of Ho-SP, suggesting that the analgesic effect occurs through a central action mechanism at the higher dose. Sw-SP and Ho-SP (10 mg/kg) significantly inhibited paw edema induced by carrageenan, especially at 3 h after treatment and potentially decreased neutrophil migration by 53% and 52%, respectively. In Freund's adjuvant-induced arthritic rats, there was a significant increase in the rat paw volume and decrease in body weight, but in Sw-SP- and Ho-SP-treated groups (10 mg/kg), a significant reduction in paw volume and a normal gain in body weight were observed. The present results indicate that Sw-SP and Ho-SP possess antinociceptive and anti-inflammatory effects and have potential usefulness for development as therapeutic agents.

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“…With only about 72 species and 13 genera, seagrasses play key ecological roles in fisheries production, sediment accumulation, and stabilization [1,3,4] and have direct value to humanity as food, feed, green manure, and medicine [5][6][7]. Phytochemical analyses of seagrass species have shown that they are potential sources of antioxidants [8][9][10][11], antibacterial, antifungal and anti-inflammatory agents [8,[12][13][14], and source of anticancer compounds [15].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Halophila Ovalis and Halophila Beccarii (Hydrocharitaceae): Two Important Seagrass Species of Chilika Lagoon, India

Kar

Sahoo

Kar

et al. 2019

Asian J Pharm Clin Res

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Objective: The present study was undertaken to evaluate the total phenolic and flavonoid content and the antioxidant property of two important seagrass species namely, Halophila ovalis and Halophila beccarii occurring in Chilika lagoon, Odisha, India. Methods: Total Phenolic Content (TPC) of the extracts of Halophila species was determined by Folin-Ciocalteu method with little modifications and the total flavonoid content (TFC) was measured by aluminum chloride colorimetric assay. The antioxidant activity of different extracts was investigated by DPPH and ABTS radical scavenging activity. IC50 values were calculated for the DPPH and ABTS methods. Result: The study revealed that the methanol extract of H. ovalis has greater antioxidant activity than H. beccarii. Methanol extract of both the species (H. ovalis and H. beccarii) was found to possess high phenolic content at value of 70.25 mg GAE/g of extract and 48.53 mg GAE/g of extract respectively. Similarly flavonoid contents was found highest in methanol extract for both H. ovalis (76.82 mg quercetin equivalent/ g of extract) and H. beccarii (64.28 mg quercetin equivalent/ g of extract). The antioxidant activity of different extracts of these two species were evaluated using DPPH and ABTS radical assay. The methanol extract of both H. ovalis and H. beccarii showed high radical scavenging activity with IC50 values of 37.77 μg/ml and 52.25 μg/ml for DPPH and 25.62 μg/ml and 45.45 μg/ml for ABTS respectively. Conclusion: The study revealed the potential of the Halophila species as natural sources of antioxidants having considerable commercial importance.

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Seagrass as a potential source of natural antioxidant and anti-inflammatory agents

Cited by 43 publications

References 40 publications

Characterization and seasonal variation of individual flavonoids in Zostera marina and Zostera noltii from Norwegian coastal waters

Characterization and seasonal variation of individual flavonoids in Zostera marina and Zostera noltii from Norwegian coastal waters

Antinociceptive and Anti-Inflammatory Activities of Sargassum wightii and Halophila ovalis Sulfated Polysaccharides in Experimental Animal Models

Antioxidant Activity of Halophila Ovalis and Halophila Beccarii (Hydrocharitaceae): Two Important Seagrass Species of Chilika Lagoon, India

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