Search for an Endogenous Ligand for the Opiate Receptor

Terenius, Lars; Wahlström, Agneta

doi:10.1111/j.1748-1716.1975.tb05863.x

Cited by 280 publications

(35 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At doses of 5 and 25 pg, A-endorphin led to a 20-to 30-fold stimulation-of levels of plasma growth hormone, the maximal effect being measured between 20 and 30 min after injection. These data su 'est the possible role of the endogenous opiate-like peptides in the control of growth hormone'secretion.…”

mentioning

confidence: 92%

Beta-endorphin: stimulation of growth hormone release in vivo.

Dupont¹,

Cusan²,

Garon³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

Two micrograms of f-endorphin (f3-lipotroPin61 il) injected intraventricularly in rats that had been treated with antiserum against somatostatin led to a 6-and 10-fold stimulation of the concentration of plasma growth hormone (somatotropin) measured 10 and 20 min after injection of the peptide, whereas-400 ug of methionine-enkephalin led to a 4-to 6-fold increase of levels of plasma growth hormone at 10 min with a rapid return to basal levels at later time intervals. At doses of 5 and 25 pg, A-endorphin led to a 20-to 30-fold stimulation-of levels of plasma growth hormone, the maximal effect being measured between 20 and 30 min after injection. These data su 'est the possible role of the endogenous opiate-like peptides in the control of growth hormone'secretion. Morphine is well known to be a potent stimulus of growth hormone (GH; somatotropin) release in the rat (1-3). This effect of the opiate is likely to be mediated by increased release of GH-releasing activity from the hypothalamus (4).Following reports of the presence of endogenous opiate activity in the brain (5-7), the pentapeptide H-Tyr-Gly-GlyPhe-Met-OH (Met-enkephalin) has been isolated from porcine brain (8). This peptide has'been shown to have potent opiate activity (8) and to bind to the opiate receptor (9, 10).The

show abstract

mentioning

confidence: 92%

Beta-endorphin: stimulation of growth hormone release in vivo.

Dupont¹,

Cusan²,

Garon³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

show abstract

“…A chromatographic fractiona tion was made and the concentration of fraction 1 was measured in a radioreceptor assay according to the method described by Terenius and Wahlstrom (22,23).…”

Section: Mopeg In Csfmentioning

confidence: 99%

Biochemistry of the Augmenting-Reducing Response in Visual Evoked Potentials

1981

View full text Add to dashboard Cite

The augmentating-reducing response in visual evoked potentials (VEP) has been shown to be a useful tool in psychiatric research. A series of studies has been devoted to the search for the biochemical basis of this phenomenon. An augmenter response in VEP is shown to be clearly related to low levels of endorphins, 5-HIAA and homovanillic acid in CSF and to low serum-dopamine-β-hydroxylase activity, while no significant relationship was found with 4-hydroxy-3-methoxyphenylethylene glycol or tryptophan in CSF or MAO in thrombocytes. The results indicate that an augmenter response in VEP is related to low activity in the serotoninergic, dopaminergic and endophinergic pathways in CNS.

show abstract

“…Endogenous ligands to the opiate receptors have been discovered (1)(2)(3)(4)(5)(6)(7). With antisera raised to such ligands, the enkephalins and the endorphins, it has been possible to localize these peptides in the nervous system of experimental animals by using immunocytochemistry.…”

mentioning

confidence: 99%

Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma.

Lundberg¹,

Hamberger²,

Schultzberg³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

187

View full text Add to dashboard Cite

By using the Coons indirect immunofluorescence technique, enkephalin-like immunoreactivity with a granular localization was observed in human adrenal medullary gland cells and pheochromocytomas. In two of the tumors and in a few adrenal gland cells, a somatostatin-like peptide could also be identified. Catecholamine cell types were visualized on adjacent sections with antisera to the synthesizing enzymes dopamine-,-hydroxylase [DBH; dopamine ,-monooxygenase; 3,4-dihydroxyphenylethylamine,ascorbate:oxygen oxidoreductase (-hydoxyating), EC 1.14.17.1] and phenylethanolamine-N-methyltransferase (PNMT; noradrenalin N-methyltransferase; S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase, EC 2.1.1.28). In the normal adrenal medulla more DBH-than PNMT-immunoreactive land cells were observed. In the adrenal pheochromocytoma both DBH-and PNMT-positive cells were seen, whereas the two extra-adrenal tumors contained only DBH. These findings correlated well with plasma catecholamine measurements. Finally, enkephalin immunoreactive fibers and somatostatin immunoreactive cells were observed in a sympathetic ganglion extirpated together with one of the tumors.

show abstract

Search for an Endogenous Ligand for the Opiate Receptor

Cited by 280 publications

References 19 publications

Beta-endorphin: stimulation of growth hormone release in vivo.

Beta-endorphin: stimulation of growth hormone release in vivo.

Biochemistry of the Augmenting-Reducing Response in Visual Evoked Potentials

Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma.

Contact Info

Product

Resources

About