Search for Genes Positively Selected during Primate Evolution by 5′-End-Sequence Screening of Cynomolgus Monkey cDNAs

Osada, Naoki; Kusuda, Jun; Hirata, Makoto; Tanuma, Reiko; Hida, Munetomo; Sugano, Sumio; Hirai, Momoki; Hashimoto, Katsuyuki

doi:10.1006/geno.2002.6753

Cited by 19 publications

(11 citation statements)

References 42 publications

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“…Comparable data have also been found for adaptive evolution of primate OXPHOS genes for complexes III, IV, and V, but not for complex II (170)(171)(172)(173)(174). Therefore, adaptive radiation of mtDNA-encoded OXPHOS genes may be especially important for intraspecific adaptation, whereas radiation of nDNA-encoded OXPHOS genes may be particularly important for interspecific radiation.…”

Section: Wwwannualreviewsorg • Mitochondrial Dna Evolution and Diseasementioning

confidence: 64%

Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

Wallace

2007

Annu. Rev. Biochem.

322

339

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The human cell is a symbiosis of two life forms, the nucleus-cytosol and the mitochondrion. The nucleus-cytosol emphasizes structure and its genes are Mendelian, whereas the mitochondrion specializes in energy and its mitochondrial DNA (mtDNA) genes are maternal. Mitochondria oxidize calories via oxidative phosphorylation (OXPHOS) to generate a mitochondrial inner membrane proton gradient (DeltaP). DeltaP then acts as a source of potential energy to produce ATP, generate heat, regulate reactive oxygen species (ROS), and control apoptosis, etc. Interspecific comparisons of mtDNAs have revealed that the mtDNA retains a core set of electron and proton carrier genes for the proton-translocating OXPHOS complexes I, III, IV, and V. Human mtDNA analysis has revealed these genes frequently contain region-specific adaptive polymorphisms. Therefore, the mtDNA with its energy controlling genes may have been retained to permit rapid adaptation to new environments.

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Section: Wwwannualreviewsorg • Mitochondrial Dna Evolution and Diseasementioning

confidence: 64%

Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

Wallace

2007

Annu. Rev. Biochem.

322

339

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“…Adaptive evolution has also influenced the primate complexes III, IV and V genes (Wu et al, 1997;Osada et al, 2002;Goldberg et al, 2003;Wildman et al, 2003;Grossman et al, 2004). Therefore, changes in mitochondrial energetics may have played an important role in the evolution of the Great Ape-Human clade.…”

Section: Discussionmentioning

confidence: 98%

“…These analyses revealed that a period of positive selection occurred after the macaque diverged from the Hominini, i.e. ∼25 million years before present (MYA), a result found independently by another group (Osada et al, 2002).…”

Section: L6imentioning

confidence: 98%

Adaptive selection of mitochondrial complex I subunits during primate radiation

Ruiz‐Pesini

Mondragón-Palomino

et al. 2006

Gene

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“…Several studies of the primate complex IV showed that seven nu OXPHOS genes: COX4I1 (Wu et al 1997; Wildman et al 2002), COX7A1H (Schmidt et al 1999), COX5A (Doan et al 2004), COX8AL (Osada et al 2002; Goldberg et al 2003), COX6B1 , COX6C , and COX7C (Doan et al 2004), together with two mt OXPHOS genes: MT-COX1 (Andrews and Easteal 2000; Wu et al 2000) and MT-COX2 (Adkins and Honeycutt 1994), have shown accelerated d N in the lineage leading to hominids relative to other primates. However, in these cases it is not clear whether accelerated d N is due to compensatory changes driven by the higher mt rate, or is due to selection for increased OXPHOS efficiency associated with increased brain size in the hominid lineage.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial–Nuclear Interactions: Compensatory Evolution or Variable Functional Constraint among Vertebrate Oxidative Phosphorylation Genes?

Zhang

Broughton

2013

Genome Biology and Evolution

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Oxidative phosphorylation (OXPHOS), the major energy-producing pathway in aerobic organisms, includes protein subunits encoded by both mitochondrial (mt) and nuclear (nu) genomes. How these independent genomes have coevolved is a long-standing question in evolutionary biology. Although mt genes evolve faster than most nu genes, maintenance of OXPHOS structural stability and functional efficiency may involve correlated evolution of mt and nu OXPHOS genes. The nu OXPHOS genes might be predicted to exhibit accelerated evolutionary rates to accommodate the elevated substitution rates of mt OXPHOS subunits with which they interact. Evolutionary rates of nu OXPHOS genes should, therefore, be higher than that of nu genes that are not involved in OXPHOS (nu non-OXPHOS). We tested the compensatory evolution hypothesis by comparing the evolutionary rates (synonymous substitution rate dS and nonsynonymous substitution rate dN) among 13 mt OXPHOS genes, 60 nu OXPHOS genes, and 77 nu non-OXPHOS genes in vertebrates (7 fish and 40 mammal species). The results from a combined analysis of all OXPHOS subunits fit the predictions of the hypothesis. However, results from two OXPHOS complexes did not fit this pattern when analyzed separately. We found that the dN of nu OXPHOS genes for “core” subunits (those involved in the major catalytic activity) was lower than that of “noncore” subunits, whereas there was no significant difference in dN between genes for nu non-OXPHOS and core subunits. This latter finding suggests that compensatory changes play a minor role in the evolution of OXPHOS genes and that the observed accelerated nu substitution rates are due largely to reduced functional constraint on noncore subunits.

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Search for Genes Positively Selected during Primate Evolution by 5′-End-Sequence Screening of Cynomolgus Monkey cDNAs

Cited by 19 publications

References 42 publications

Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

Adaptive selection of mitochondrial complex I subunits during primate radiation

Mitochondrial–Nuclear Interactions: Compensatory Evolution or Variable Functional Constraint among Vertebrate Oxidative Phosphorylation Genes?

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