Search for schizophrenia and bipolar biotypes using functional network properties

Fernández-Linsenbarth, Inés; Planchuelo‐Gómez, Álvaro; Beño-Ruiz-de-la-Sierra, Rosa M.; Díez, Álvaro; Arjona, Antonio; Pérez, Adela Garzón; Rodríguez-Lorenzana, Alberto; Valle, Pilar del; Luis‐García, Rodrigo de; Mascialino, Guido; Holgado-Madera, Pedro; Segarra-Echevarría, Rafael; Gómez‐Pilar, Javier; Núñez, Pablo; Bote-Boneaechea, Berta; Zambrana-Gómez, Antonio; Roig-Herrero, Alejandro; Molina, Vicente

doi:10.1002/brb3.2415

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…One alternative approach to categorizing CNS disorders discussed by Clementz et al (2016) is to instead consider classification based on biological phenotype or “ biotype ” that includes a biological and phenotypic marker that better stratifies conditions with overlapping phenotypic features. Here the analysis of the retinal functional measures may help identify biotypes within the neurodevelopmental ( Dacquino et al, 2015 ; Barth et al, 2018 ; Liang et al, 2019 , 2020 ; Fernández-Linsenbarth et al, 2021 ) and neurodegenerative domains ( Wang et al, 2020 ) that contribute to a diagnostic categorization system which aligns more closely with neurobiology and clinical phenotype ( Brucar et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies

2023

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The retina and brain share similar neurochemistry and neurodevelopmental origins, with the retina, often viewed as a “window to the brain.” With retinal measures of structure and function becoming easier to obtain in clinical populations there is a growing interest in using retinal findings as potential biomarkers for disorders affecting the central nervous system. Functional retinal biomarkers, such as the electroretinogram, show promise in neurological disorders, despite having limitations imposed by the existence of overlapping genetic markers, clinical traits or the effects of medications that may reduce their specificity in some conditions. This narrative review summarizes the principal functional retinal findings in central nervous system disorders and related mouse models and provides a background to the main excitatory and inhibitory retinal neurotransmitters that have been implicated to explain the visual electrophysiological findings. These changes in retinal neurochemistry may contribute to our understanding of these conditions based on the findings of retinal electrophysiological tests such as the flash, pattern, multifocal electroretinograms, and electro-oculogram. It is likely that future applications of signal analysis and machine learning algorithms will offer new insights into the pathophysiology, classification, and progression of these clinical disorders including autism, attention deficit/hyperactivity disorder, bipolar disorder, schizophrenia, depression, Parkinson’s, and Alzheimer’s disease. New clinical applications of visual electrophysiology to this field may lead to earlier, more accurate diagnoses and better targeted therapeutic interventions benefiting individual patients and clinicians managing these individuals and their families.

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Section: Discussionmentioning

confidence: 99%

Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies

2023

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Search for schizophrenia and bipolar biotypes using functional network properties

Fernández-Linsenbarth

Planchuelo‐Gómez

Beño-Ruiz-de-la-Sierra

et al. 2021

Brain and Behavior

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Introduction:Recent studies support the identification of valid subtypes within schizophrenia and bipolar disorder using cluster analysis. Our aim was to identify meaningful biotypes of psychosis based on network properties of the electroencephalogram. We hypothesized that these parameters would be more altered in a subgroup of patients also characterized by more severe deficits in other clinical, cognitive, and biological measurements. Methods: A clustering analysis was performed using the electroencephalogram-based network parameters derived from graph-theory obtained during a P300 task of 137 schizophrenia (of them, 35 first episodes) and 46 bipolar patients. Both prestimulus and modulation of the electroencephalogram were included in the analysis. Demographic, clinical, cognitive, structural cerebral data, and the modulation of the spectral entropy of the electroencephalogram were compared between clusters. Data from 158 healthy controls were included for further comparisons. Results:We identified two clusters of patients. One cluster presented higher prestimulus connectivity strength, clustering coefficient, path-length, and lower small-worldThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology

Joseph

Gianella

Burdo

et al. 2023

The Journal of Infectious Diseases

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Despite viral suppression with antiretroviral therapy (ART), people with human immunodeficiency virus (HIV) continue to experience central nervous system (CNS) complications, primarily in the form of mild cognitive impairment and mental health disorders (eg, depression, anxiety, other neuropsychiatric problems). The multifactorial pathogenesis and heterogeneity of mechanisms likely underlying CNS complications must be addressed in the development of preventive interventions and effective treatments. The biotyping approach has previously been useful to define phenotypes of other CNS diseases based on underlying mechanisms and could be translated to the field of neuroHIV. The purpose of the Biotype Workshop series, and the Virology, Immunology and Neuropathology Working Group in particular, is to capitalize on current and new technologies and guide future research efforts using the wealth of available immunological, virologic, and neuropathological data collected from people with HIV on and off ART.

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Search for schizophrenia and bipolar biotypes using functional network properties

Cited by 3 publications

References 56 publications

Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies

Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies

Search for schizophrenia and bipolar biotypes using functional network properties

Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology

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