Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution

Orelli, Johannes von; Leuenberger, Hans

doi:10.1016/j.ijpharm.2004.09.006

Cited by 23 publications

(16 citation statements)

References 16 publications

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“…Dissolution efficiency data (Table VI) shows that capsules and tablets produced with FCZ presented similar dissolution behavior to that of an extended-release formulation. This finding is in accordance with the studies of Orelli and Leuenberger (2004) who found similar results in a study on release from tablets produced with granules of proquazone. These authors considered this dissolution behavior a characteristic of poorly wettable drugs.…”

Section: Dosage Forms and Dissolution Studiessupporting

confidence: 93%

Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

Consiglieri

Mourão

Sampaio

et al. 2010

Braz. J. Pharm. Sci.

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The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone Ò K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies were achieved with Plasdone ® K29/32.Uniterms: Fluconazole/flowability. Tablets/dissolution. Capsules/dissolution. Plasdone Ò O objetivo deste trabalho foi melhorar as características de fluxo do fluconazol com o emprego da granulação úmida e estudar o efeito desse processo na dissolução do fármaco em cápsulas e comprimidos. O fluconazol foi submetido ao processo de granulação úmida num granulador de alta velocidade empregando Plasdone Ò K29/32 e K90. Foram determinadas as propriedades de fluxo dos grânulos e obtidos os perfis de dissolução de cápsulas e comprimidos obtidos com os granulados em estudo. Os grânulos de fluconazol apresentaram melhores características de fluxo após o processamento, demonstradas por meio das determinações do ângulo de repouso e do índice de compressibilidade, comparativamente à matéria-prima. Adicionalmente, observou-se que o processo de granulação melhorou a eficiência de dissolução (ED) do fluconazol nos comprimidos e cápsulas.

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Section: Dosage Forms and Dissolution Studiessupporting

confidence: 93%

Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

Consiglieri

Mourão

Sampaio

et al. 2010

Braz. J. Pharm. Sci.

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“…The first disintegrating agents to be used in tablet formulations were native starches of maize, potato, and wheat [6]. In general, native starches lack the ideal characteristics of tablet disintegrants.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations

Adjei

Osei

Kuntworbe

et al. 2017

Journal of Pharmaceutics

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The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops Research Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0 to 26.7%. The starches were basic (pH: 8.1–9.9), with satisfactory moisture content (≤15%), swelling capacity (≥20%), ash values (<1%), flow properties, and negligible toxic metal ion content, and compatible with the drug. The tensile strength (Ts), crushing strength (Cs), and friability (Ft) of tablets containing 5–10% w/w of the cassava starches were similar (p > 0.05) to those containing maize starch BP. The disintegration times of the tablets decreased with increase in concentration of the cassava starches. The tablets passed the disintegration test (DT ≤ 15 min) and exhibited faster disintegration times (p > 0.05) than those containing maize starch BP. The disintegration efficiency ratio (DER) and the disintegration parameter DERc of the tablets showed that cassava starches V20, V40, and V50 had better disintegrant activity than maize starch BP. The tablets passed the dissolution test for immediate release tablets (≥70% release in 45 min) with dissolution rates similar to those containing maize starch BP.

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“…Pressure agglomeration can be performed on a variety of materials with different types of presses 1. Tablets are the most often administered dosage form for delivering active compounds such as drugs, vitamins or food supplements and are easy to handle, store, dispense, and produce in large quantities 2, 3. Maltodextrins have been extensively used as ingredients for preparing direct compression tablets 4.…”

Section: Introductionmentioning

confidence: 99%

Water droplet spreading and recoiling upon contact with thick–compact maltodextrin agglomerates

Meraz-Torres¹,

Quintanilla‐Carvajal²,

Téllez‐Medina³

et al. 2011

J Sci Food Agric

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Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution

Cited by 23 publications

References 16 publications

Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations

Water droplet spreading and recoiling upon contact with thick–compact maltodextrin agglomerates

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