Searching for a single mathematical function to address the nonlinear retention time shifts problem in nanoLC-MS data: A fuzzy-evolutionary computational proteomics approach

Abstract

Abstract-Proteomics involves collecting and analyzing information about proteins within one or more complex samples in order to address a biological problem. One methodology is the use of high performance liquid chromatography coupled mass spectrometry (nanoLC-MS). In such a case, the accurate determination of non-linear peptide retention times between runs is expected to increase the number of identified peptides and hence, proteins. There are many approaches when using a computer for such a problem; including very interactive to completely non-interactive algorithms for finding global and local functions that may be either explicit or implicit.This