Searching for Links between Endotoxin Exposure and Pregnancy Loss: CD14 Polymorphism in Idiopathic Recurrent Miscarriage

Abstract

Although we were not able to find a statistically significant association between CD14 genotypes and IRM in our relatively small study population, a further study with a larger sample size is warranted to explore the role of high-producing CD14 genotypes in IRM. Also studies highlighting environmental LPS triggers and other intrinsic mediators of LPS signalling are needed to solve the enigmatic role of LPS in IRM in humans.

Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma Production by Decidual Mononuclear Cells (DMNC) is Interleukin (IL)-2 and IL-12 Dependent

“…In humans, clinical studies suggest possible involvement of LPS in recurrent spontaneous abortions and premature labor 7–9 . Effects of LPS on primary placental tissue culture and trophoblasts have been studied intensively, though their effects on human decidual immune cells are poorly understood.…”

Ecology of Danger‐dependent Cytokine‐boosted Spontaneous Abortion in the CBA × DBA/2 Mouse Model. I. Synergistic Effect of LPS and (TNF‐α + IFN‐γ) on Pregnancy Loss

“…Do ‘absorbed danger signals’, apart from the neuroendocrine effects of stress, play a role in human miscarriages? There has been no evidence of increased expression of the CD14 LPS receptor in couples with recurrent miscarriages 41 . However, levels of the circulating blood protein α ‐mannan that binds bacterial carbohydrates (such as the saccharide portion of LPS) have been reported to be significantly lower in women with RSA and low mannan levels increased the odds of a subsequent miscarriage 42,43 .…”